Disulfidptosis: Six Riddles Necessitating Solutions

Wang, Xinyu; Zheng, Chanjuan; Yao, Hui; Guo, Yuxuan; Wang, Yian; He, Guangchun; Fu, Shujun; Deng, Xiyun

doi:10.7150/ijbs.90606

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Int J Biol Sci 2024; 20(3):1042-1044. doi:10.7150/ijbs.90606 This issue Cite

Editorial

Disulfidptosis: Six Riddles Necessitating Solutions

Xinyu Wang¹, Chanjuan Zheng¹, Hui Yao^1,2, Yuxuan Guo¹, Yian Wang¹, Guangchun He¹, Shujun Fu¹, Xiyun Deng^1✉

1. Key Laboratory of Translational Cancer Stem Cell Research, Department of Pathophysiology, Hunan Normal University School of Medicine, Changsha, Hunan 410013, China.
2. Department of Pathology, Xiangtan Central Hospital, Xiangtan, Hunan 411100, China.

Citation:

Wang X, Zheng C, Yao H, Guo Y, Wang Y, He G, Fu S, Deng X. Disulfidptosis: Six Riddles Necessitating Solutions. Int J Biol Sci 2024; 20(3):1042-1044. doi:10.7150/ijbs.90606. https://www.ijbs.com/v20p1042.htm

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Abstract

Disulfidptosis occurs as a result of the accumulation of intracellular cystine followed by disulfide stress in actin cytoskeleton proteins due to a reduction of NADPH produced through the pentose phosphate pathway in cells with high expression of SLC7A11. It is a cell death caused by the redox imbalance resulting from the disruption of amino acid metabolism and glucose metabolism. The discovery of disulfidptosis has sparked immense enthusiasm, but there are numerous unresolved issues that need to be addressed. Solutions to these riddles will provide insights into the detailed mechanisms and the pathophysiological relevance of disulfidptosis and utilizing disulfidptosis as an actionable therapeutic target.

Keywords: Programmed cell death, Disulfidptosis, Disulfide stress, Actin cytoskeleton, Cellular metabolism

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APA

Wang, X., Zheng, C., Yao, H., Guo, Y., Wang, Y., He, G., Fu, S., Deng, X. (2024). Disulfidptosis: Six Riddles Necessitating Solutions. International Journal of Biological Sciences, 20(3), 1042-1044. https://doi.org/10.7150/ijbs.90606.

ACS

Wang, X.; Zheng, C.; Yao, H.; Guo, Y.; Wang, Y.; He, G.; Fu, S.; Deng, X. Disulfidptosis: Six Riddles Necessitating Solutions. Int. J. Biol. Sci. 2024, 20 (3), 1042-1044. DOI: 10.7150/ijbs.90606.

NLM

CSE

Wang X, Zheng C, Yao H, Guo Y, Wang Y, He G, Fu S, Deng X. 2024. Disulfidptosis: Six Riddles Necessitating Solutions. Int J Biol Sci. 20(3):1042-1044.

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