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Int J Biol Sci 2024; 20(4):1375-1388. doi:10.7150/ijbs.85851 This issue Cite

Research Paper

Dioscin Alleviates Periodontitis by Inhibiting NLRP3 Inflammasome Activation via Regulation of K+ Homeostasis and Mitochondrial Function

Xue Jiang*, Xinxin Ding*, Jianxu Wei, Xiaolei Lv, Yi Zhang, Yijie Yang, Hongchang Lai✉, Xiaomeng Zhang✉

Department of Oral and Maxillofacial Implantology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology, Shanghai 200011, China.
* Xue Jiang and Xinxin Ding contributed equally to this work.

✉ Corresponding authors: Xiaomeng Zhang, Email: zhangxiaomengwowocom. Hongchang Lai, Email: hongchanglaicom.

Citation:
Jiang X, Ding X, Wei J, Lv X, Zhang Y, Yang Y, Lai H, Zhang X. Dioscin Alleviates Periodontitis by Inhibiting NLRP3 Inflammasome Activation via Regulation of K+ Homeostasis and Mitochondrial Function. Int J Biol Sci 2024; 20(4):1375-1388. doi:10.7150/ijbs.85851. https://www.ijbs.com/v20p1375.htm
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Abstract

Graphic abstract

Gingival inflammation and alveolar bone loss are characteristic manifestations of periodontitis. Interleukin (IL)-1β, the maturation of which is mainly regulated by NOD-like receptor protein (NLRP) 3 inflammasome, not only amplifies the inflammatory response but also triggers osteoclastogenesis, thereby accelerating the progression of periodontitis. Dioscin, a natural steroid saponin, has been shown to inhibit NLRP3 inflammasome. Nevertheless, research on the effectiveness of Dioscin for the management of periodontitis remains scarce. In this study, Dioscin was found to dramatically reduce the integral components of NLRP3 inflammasome, ultimately limiting IL-1β secretion. Notably, the inhibitory impact of Dioscin on NLRP3 inflammasome might be exerted by curbing the generation of mitochondrial (mt) reactive oxygen species (ROS) and oxidized (ox) mtDNA, which were mediated by inhibition of K+ efflux. Furthermore, Dioscin effectively alleviated periodontitis in mice. Overall, the results established that Dioscin could alleviate periodontitis by inhibiting NLRP3 inflammasome via modulation of the K+ efflux-mtROS-ox-mtDNA pathway, holding the potential to treat periodontitis and other NLRP3-driven inflammatory diseases.

Keywords: Periodontitis, Dioscin, NLRP3 inflammasome, mtROS, ox-mtDNA, K+ efflux.

Citation styles

APA
Jiang, X., Ding, X., Wei, J., Lv, X., Zhang, Y., Yang, Y., Lai, H., Zhang, X. (2024). Dioscin Alleviates Periodontitis by Inhibiting NLRP3 Inflammasome Activation via Regulation of K+ Homeostasis and Mitochondrial Function. International Journal of Biological Sciences, 20(4), 1375-1388. https://doi.org/10.7150/ijbs.85851.

ACS
Jiang, X.; Ding, X.; Wei, J.; Lv, X.; Zhang, Y.; Yang, Y.; Lai, H.; Zhang, X. Dioscin Alleviates Periodontitis by Inhibiting NLRP3 Inflammasome Activation via Regulation of K+ Homeostasis and Mitochondrial Function. Int. J. Biol. Sci. 2024, 20 (4), 1375-1388. DOI: 10.7150/ijbs.85851.

NLM
Jiang X, Ding X, Wei J, Lv X, Zhang Y, Yang Y, Lai H, Zhang X. Dioscin Alleviates Periodontitis by Inhibiting NLRP3 Inflammasome Activation via Regulation of K+ Homeostasis and Mitochondrial Function. Int J Biol Sci 2024; 20(4):1375-1388. doi:10.7150/ijbs.85851. https://www.ijbs.com/v20p1375.htm

CSE
Jiang X, Ding X, Wei J, Lv X, Zhang Y, Yang Y, Lai H, Zhang X. 2024. Dioscin Alleviates Periodontitis by Inhibiting NLRP3 Inflammasome Activation via Regulation of K+ Homeostasis and Mitochondrial Function. Int J Biol Sci. 20(4):1375-1388.

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