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Int J Biol Sci 2009; 5(1):20-27. doi:10.7150/ijbs.5.20


BRCA1, Hormone, and Tissue-Specific Tumor Suppression

Yanfen Hu

Department of Molecular Medicine/Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA


Germline mutations of BRCA1 predispose women to breast and ovarian cancers. Elucidating molecular mechanism of tissue- and gender-specific phenomena in BRCA1-related tumors is a key to our understanding of BRCA1 function in tumor suppression. This review summarizes studies in recent years on the link between BRCA1 and estrogen/progesterone signaling pathways, as well as discusses various models underscoring a triangle relationship among BRCA1, estrogen and genome instability.

Keywords: BRCA1, tumor suppression, estrogen, genome instability.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
How to cite this article:
Hu Y. BRCA1, Hormone, and Tissue-Specific Tumor Suppression. Int J Biol Sci 2009; 5(1):20-27. doi:10.7150/ijbs.5.20. Available from