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Int J Biol Sci 2011; 7(9):1239-1256. doi:10.7150/ijbs.7.1239

Review

Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections

Juan de Dios Rosado, Miriam Rodriguez-Sosa

Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), 54090 Tlalnepantla, Estado de México, México.

Abstract

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by the pituitary gland and multiple cell types, including macrophages (Mø), dendritic cells (DC) and T-cells. Upon releases MIF modulates the expression of several inflammatory molecules, such as TNF-α, nitric oxide and cyclooxygenase 2 (COX-2). These important MIF characteristics have prompted investigators to study its role in parasite infections. Several reports have demonstrated that MIF plays either a protective or deleterious role in the immune response to different pathogens. Here, we review the role of MIF in the host defense response to some important protozoan infections.

Keywords: Macrophage migration inhibitory factor, Protozoan infections, Inflammatory response, Control of parasite infections, innate immune response.

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How to cite this article:
de Dios Rosado J, Rodriguez-Sosa M. Macrophage Migration Inhibitory Factor (MIF): A Key Player in Protozoan Infections. Int J Biol Sci 2011; 7(9):1239-1256. doi:10.7150/ijbs.7.1239. Available from http://www.ijbs.com/v07p1239.htm