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Int J Biol Sci 2013; 9(5):435-443. doi:10.7150/ijbs.6087

Review

The C-Kit Receptor-Mediated Signal Transduction and Tumor-Related Diseases

Jing Liang1, Yan-Ling Wu2✉, Bing-Jia Chen1, Wen Zhang1✉, Yoshimasa Tanaka3, Hiroshi Sugiyama4

1. Department of Biopharmaceutical Science, College of Pharmaceutical Sciences, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou, 310014, China.
2. Virus Inspection Department, Zhejiang Provincial Center for Disease Control and Prevention, 630 Xincheng Road, Hangzhou, 310051, China.
3. Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.
4. Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.

Abstract

As an important member of tyrosine kinase family, c-kit receptor causes specific expression of certain genes, regulates cell differentiation and proliferation, resists cell apoptosis, and plays a key role in tumor occurrence, development, migration and recurrence through activating the downstream signaling molecules following interaction with stem cell factor (SCF). The abnormality of SCF/c-kit signaling pathway is closely related to some certain tumors. The discovery of c-kit receptor-targeted drugs has promoted clinical-related cancer's diagnosis and treatment. In this paper, we review recent research progress on c-kit receptor-mediated signal transduction and its potential therapeutic application as a target in tumor-related diseases.

Keywords: c-kit receptor, signal transduction, tumor, targeted therapy

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How to cite this article:
Liang J, Wu YL, Chen BJ, Zhang W, Tanaka Y, Sugiyama H. The C-Kit Receptor-Mediated Signal Transduction and Tumor-Related Diseases. Int J Biol Sci 2013; 9(5):435-443. doi:10.7150/ijbs.6087. Available from http://www.ijbs.com/v09p0435.htm