Int J Biol Sci 2013; 9(5):435-443. doi:10.7150/ijbs.6087
The C-Kit Receptor-Mediated Signal Transduction and Tumor-Related Diseases
1. Department of Biopharmaceutical Science, College of Pharmaceutical Sciences, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou, 310014, China.
As an important member of tyrosine kinase family, c-kit receptor causes specific expression of certain genes, regulates cell differentiation and proliferation, resists cell apoptosis, and plays a key role in tumor occurrence, development, migration and recurrence through activating the downstream signaling molecules following interaction with stem cell factor (SCF). The abnormality of SCF/c-kit signaling pathway is closely related to some certain tumors. The discovery of c-kit receptor-targeted drugs has promoted clinical-related cancer's diagnosis and treatment. In this paper, we review recent research progress on c-kit receptor-mediated signal transduction and its potential therapeutic application as a target in tumor-related diseases.
Keywords: c-kit receptor, signal transduction, tumor, targeted therapy
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How to cite this article:
Liang J, Wu YL, Chen BJ, Zhang W, Tanaka Y, Sugiyama H. The C-Kit Receptor-Mediated Signal Transduction and Tumor-Related Diseases. Int J Biol Sci 2013; 9(5):435-443. doi:10.7150/ijbs.6087. Available from http://www.ijbs.com/v09p0435.htm