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Int J Biol Sci 2017; 13(2):198-208. doi:10.7150/ijbs.17240

Review

Reverse the Resistance to PARP Inhibitors

Yevgeniy Kim1*, Aleksei Kim1*, Ainur Sharip1*, Aigul Sharip1*, Juhong Jiang2, Qing Yang1, Yingqiu Xie1✉

1. Department of Biology, Nazarbayev University, School of Science and Technology, Astana, 010000, Republic of Kazakhstan;
2. Department of Pathology, the First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
* Co-first authors.

Abstract

One of the DNA repair machineries is activated by Poly (ADP-ribose) Polymerase (PARP) enzyme. Particularly, this enzyme is involved in repair of damages to single-strand DNA, thus decreasing the chances of generating double-strand breaks in the genome. Therefore, the concept to block PARP enzymes by PARP inhibitor (PARPi) was appreciated in cancer treatment. PARPi has been designed and tested for many years and became a potential supplement for the conventional chemotherapy. However, increasing evidence indicates the appearance of the resistance to this treatment. Specifically, cancer cells may acquire new mutations or events that overcome the positive effect of these drugs. This paper describes several molecular mechanisms of PARPi resistance which were reported most recently, and summarizes some strategies to reverse this type of drug resistance.

Keywords: PARP, PARP inhibitor, drug resistance, DNA repair

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Kim Y, Kim A, Sharip A, Sharip A, Jiang J, Yang Q, Xie Y. Reverse the Resistance to PARP Inhibitors. Int J Biol Sci 2017; 13(2):198-208. doi:10.7150/ijbs.17240. Available from http://www.ijbs.com/v13p0198.htm