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Int J Biol Sci 2018; 14(12):1636-1644. doi:10.7150/ijbs.28089

Review

Role of canonical Hedgehog signaling pathway in liver

Lili Gao1*, Zhenya Zhang2*, Peng Zhang1, Minghua Yu3✉, Tao Yang1✉

1. Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, China
2. Department of general surgery, Hebei Medical University Fourth Hospital, Shijiazhuang, 050011, China
3. Department of Oncology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China
*These two authors contributed equally to this work.

Abstract

Hedgehog (Hh) signaling pathway plays an important role in embryonic development. It becomes reactivated in many types of acute and chronic liver injuries. Hh signaling is required for liver regeneration, regulates capillarisation, controls the fates of hepatic stellate cells, promotes liver fibrosis and liver cancers. In this review, we summarize the current knowledge of the role of canonical Hh signaling pathway in adult liver. This help to understand the pathogenesis of liver diseases and find out the new effective targeted therapeutic strategies for liver diseases treatments.

Keywords: Hedgehog, liver, fibrosis, HCC

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Gao L, Zhang Z, Zhang P, Yu M, Yang T. Role of canonical Hedgehog signaling pathway in liver. Int J Biol Sci 2018; 14(12):1636-1644. doi:10.7150/ijbs.28089. Available from http://www.ijbs.com/v14p1636.htm