Int J Biol Sci
2011; 7(8):1114-1121.
doi:10.7150/ijbs.7.1114 This issueCite
Research Paper
FRS2α is Essential for the Fibroblast Growth Factor to Regulate the mTOR Pathway and Autophagy in Mouse Embryonic Fibroblasts
Xiang Lin1,2,#, Yongyou Zhang1,*, Leyuan Liu1, Wallace L. McKeehan1, Yuemao Shen2, Siyang Song2,✉, Fen Wang1,✉
1. Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX; 2. The Key Laboratory of Education Ministry for Cell Biology and Tumor Cell Engineering; School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, P. R. China. # Current address: Institute of Life Sciences, Fuzhou University, Fuzhou, Fujian, 350108, P. R. China; * Current address: Howard Hughes Medical Institute Laboratory, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106-7285.
✉ Corresponding author: Fen Wang: Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030-3303. E-mail: fwangtamhsc.edu; Siyang Song, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, P. R. China, sysongedu.cn.More
Citation:
Lin X, Zhang Y, Liu L, McKeehan WL, Shen Y, Song S, Wang F. FRS2α is Essential for the Fibroblast Growth Factor to Regulate the mTOR Pathway and Autophagy in Mouse Embryonic Fibroblasts. Int J Biol Sci 2011; 7(8):1114-1121. doi:10.7150/ijbs.7.1114. https://www.ijbs.com/v07p1114.htm
Although the fibroblast growth factor (FGF) signaling axis plays important roles in cell survival, proliferation, and differentiation, the molecular mechanism underlying how the FGF elicits these diverse regulatory signals is not well understood. By using the Frs2α null mouse embryonic fibroblast (MEF) in conjunction with inhibitors to multiple signaling pathways, here we report that the FGF signaling axis activates mTOR via the FGF receptor substrate 2α (FRS2α)-mediated PI3K/Akt pathway, and suppresses autophagy activity in MEFs. In addition, the PI3K/Akt pathway regulated mTOR is crucial for the FGF signaling axis to suppress autophagy in MEFs. Since autophagy has been proposed to play important roles in cell survival, proliferation, and differentiation, the findings suggest a novel mechanism for the FGF signaling axis to transmit regulatory signals to downstream effectors.
Lin, X., Zhang, Y., Liu, L., McKeehan, W.L., Shen, Y., Song, S., Wang, F. (2011). FRS2α is Essential for the Fibroblast Growth Factor to Regulate the mTOR Pathway and Autophagy in Mouse Embryonic Fibroblasts. International Journal of Biological Sciences, 7(8), 1114-1121. https://doi.org/10.7150/ijbs.7.1114.
ACS
Lin, X.; Zhang, Y.; Liu, L.; McKeehan, W.L.; Shen, Y.; Song, S.; Wang, F. FRS2α is Essential for the Fibroblast Growth Factor to Regulate the mTOR Pathway and Autophagy in Mouse Embryonic Fibroblasts. Int. J. Biol. Sci. 2011, 7 (8), 1114-1121. DOI: 10.7150/ijbs.7.1114.
NLM
Lin X, Zhang Y, Liu L, McKeehan WL, Shen Y, Song S, Wang F. FRS2α is Essential for the Fibroblast Growth Factor to Regulate the mTOR Pathway and Autophagy in Mouse Embryonic Fibroblasts. Int J Biol Sci 2011; 7(8):1114-1121. doi:10.7150/ijbs.7.1114. https://www.ijbs.com/v07p1114.htm
CSE
Lin X, Zhang Y, Liu L, McKeehan WL, Shen Y, Song S, Wang F. 2011. FRS2α is Essential for the Fibroblast Growth Factor to Regulate the mTOR Pathway and Autophagy in Mouse Embryonic Fibroblasts. Int J Biol Sci. 7(8):1114-1121.