International Journal of Biological Sciences
ISSN: 1449-2288
10
Impact Factor
ISSN: 1449-2288
Global reach, higher impactVolume 22 (2); 2026
Editorial
Virtual lab of artificial intelligence agents accelerating nanobody design against SARS-CoV-2 variants
Hakjin Kim, Taeho Kwon, Sun-Uk Kim, Seon-Kyu Kim
Int. J. Biol. Sci. 2026; 22(2): 618-621. doi:10.7150/ijbs.126093
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Research Papers
Impact of rare JAK/STAT germline mutations on vaccination-induced innate immune responses in a Tyrolian population
Lothar Hennighausen, Gyuhyeok Cho, Sung-Gwon Lee, Yasmin Caf, Jungwook Kim, Ludwig Knabl, Priscilla A. Furth, Hye Kyung Lee
Int. J. Biol. Sci. 2026; 22(2): 519-528. doi:10.7150/ijbs.124098
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AVN944 Elicits Apoptotic Responses and Impedes Tumorigenic Potential in Ewing's Sarcoma Cells
Hanah Lim, Seonock Lee, Gamin Kim, Eun Joo Lee, Jungho Kim
Int. J. Biol. Sci. 2026; 22(2): 529-552. doi:10.7150/ijbs.116651
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Disrupted astrocyte-neuron glutamine-glutamate cycling in the medial prefrontal cortex contributes to depression-like behaviors
Jae Soon Kang, Ji Hyeong Baek, Hyeongchan Park, Naveed Ur Rehman, Hye Jin Chung, Dong Kun Lee, Sekyung Oh, Hyun Joon Kim
Int. J. Biol. Sci. 2026; 22(2): 553-565. doi:10.7150/ijbs.123740
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Hepatic Aquaporin 8 Promotes Alcohol Consumption and Ameliorates Alcohol-Induced Liver Injury by Facilitating Acetaldehyde Excretion
Cheng Chen, Yu-Hong Lin, Dechun Feng, Yukun Guan, Yaojie Fu, Yang Wang, Luca Maccioni, Deniz Seyhan, Tiantian Yao, Shoupeng Wei, Li Zhang, George Kunos, Bryan Mackowiak, Bin Gao
Int. J. Biol. Sci. 2026; 22(2): 566-581. doi:10.7150/ijbs.122713
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Dual Phosphorylation of STAT1 at Y701/S727 by TNFα Drives AIM2-Mediated PANoptosis of Renal Tubular Epithelial Cells and Fibrotic Progression in Renal Allografts
Qianguang Han, Jiawen Liu, Jianjian Zhang, Qinghuan Shen, Junqi Zhang, Shuang Fei, Hao Chen, Li Sun, Zhengkai Huang, Zhijian Han, Jun Tao, Min Gu, Xiaobing Ju, Ruoyun Tan
Int. J. Biol. Sci. 2026; 22(2): 582-600. doi:10.7150/ijbs.123441
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IGF2BP2 Drives Thyroid Cancer Dedifferentiation Through m6A-Dependent STAT1 mRNA Destabilization
Rui Chen, Yi-xun Li, Wei-lin Lu, Ke-fei Wu, Yu-xin Wang, Zi-wen Wang, Yi-han Li, Hai-yan Yang, Xu Zhang, Liang Shi, Dong Zhou, Ying Wang, Qiang Ding
Int. J. Biol. Sci. 2026; 22(2): 622-640. doi:10.7150/ijbs.121503
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Targeting the HSP60/p53 Axis with Extracellular Vesicle-Delivered siRNA Reprograms Glycolysis in Prostate Cancer
Meng-Yao Xu, Sheng Ma, Si-Yang Ma, Chen-Qian Liu, Jian-Xuan Sun, Ye An, Jin-Zhou Xu, Si-Han Zhang, Na Zeng, Xing-Yu Zhong, Xiao-Hua Zhu, Shao-Gang Wang, Qi-Dong Xia
Int. J. Biol. Sci. 2026; 22(2): 641-662. doi:10.7150/ijbs.120760
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PTPN22 Dephosphorylates CBL to Inhibit PD-L1 Ubiquitination and Drive Immunosuppression in Renal Cell Carcinoma
Taian Jin, Jiahui Ma, Luping Wang, Xinbo Liu, Mengting Wu, Binqi Wang, Chan Gao, Siqi Zhu, Ruikai Zhang, Fanwei Xia, Jingkui Tian, Wei Zhu, Juan Jin, Qiang He
Int. J. Biol. Sci. 2026; 22(2): 663-683. doi:10.7150/ijbs.122418
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DCBLD1 Promotes Lung Tumorigenesis by Inhibiting PTP1B Dephosphorylation of EGFR
Ying Liu, Yangyang Li, Xiaowei Quan, Jiayi Zhang, Zhicong Wang, Zhaoyuan Hou, Herbert Yu, Haipeng Liu, Tengteng Zhu, Biyun Qian
Int. J. Biol. Sci. 2026; 22(2): 684-700. doi:10.7150/ijbs.112100
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rBCG-LTAK63 Outperforms BCG in Bladder Cancer Immunotherapy: Dendritic and T Cell Coordination Drives Superior Tumor Control in a Mouse Model
Matheus Ferreira de Almeida, Bruna Gennari Rosa, Daniela Delechiave, Lucas Francisco Annequin, Lazaro Moreira Marques-Neto, Monalisa Martins Trentini, Johanna Christine van Vliet, Isabelle Carolina Cotrim Gozzi, Ana Carolina de Oliveira Carvalho, Dunia Rodriguez, Lennon Ramos Pereira, Giana Carla Gaboardi, Luís Carlos de Souza Ferreira, Luciana Cezar de Cerqueira Leite, Ana Carolina Ramos Moreno
Int. J. Biol. Sci. 2026; 22(2): 713-730. doi:10.7150/ijbs.118329
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Parkin Deficiency Impairs ER-Mitochondria Associations and calcium homeostasis via IP3R-Grp75-VDAC1 Complex
Nai-Jia Xue, Yi Liu, Zhi-Hao Lin, Wen-Hao Huang, Feng Zhang, Ran Zheng, Xiao-Li Si, Lu-Yan Gu, Yi Fan, Jia-Li Pu, Bao-Rong Zhang
Int. J. Biol. Sci. 2026; 22(2): 731-749. doi:10.7150/ijbs.121759
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Crosstalk between arachidonic acid metabolism and glycolysis drives integrated metabolic-inflammatory reprogramming in macrophages
Yuanyuan Cheng, Ni Fan, Xiuying Zhang, Wei Zhao, Baoping Xie, Jia Zhao, Marlene Rong, Xuechen Li, Hung-Fat Tse, Jianhui Rong
Int. J. Biol. Sci. 2026; 22(2): 771-785. doi:10.7150/ijbs.116671
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Reviews
Decoding Epigenetic Switches: How Histone Acetylation/Deacetylation Regulates Mononuclear/Macrophage Fate in Bone Disorders
Li Xu, Chen Shen, Xin Liu, Yi Qin, Zebin Wu, Ziyu Zhang, Qifeng Sheng, Qihan Wang, Feng Zhou, Gaoran Ge, Dechun Geng
Int. J. Biol. Sci. 2026; 22(2): 601-617. doi:10.7150/ijbs.125544
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The Role of Hedgehog Signaling in Non-small Cell Lung Cancer: Targeting Tumor Invasion, Therapy Resistance and Novel Therapeutic Strategies
Yu Kang, Hongmei Zheng, Qiuyuan Wen, Songqing Fan
Int. J. Biol. Sci. 2026; 22(2): 701-712. doi:10.7150/ijbs.123287
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Microbiota-gut-kidney axis in health and renal disease
Ying Jin, Shui-Juan Zhang, Shougang Zhuang, Ping Li, Hua Miao, Ying-Yong Zhao
Int. J. Biol. Sci. 2026; 22(2): 750-770. doi:10.7150/ijbs.125140
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