toc.jpg

Research Paper
Upregulated GRB7 promotes proliferation and tumorigenesis of Bladder Cancer via Phospho-AKT Pathway
Yingchun Zheng, Yuanyuan Pei, Le Yang, Zhi Zeng, Jie Wang, Guie Xie, Lan Wang, Jie Yuan
Int. J. Biol. Sci. 2020; 16(16): 3221-3230. doi:10.7150/ijbs.49410
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Postoperative adjuvant TACE-associated nomogram for predicting the prognosis of resectable Hepatocellular Carcinoma with portal vein Tumor Thrombus after Liver Resection
Fuchen Liu, Xinggang Guo, Wei Dong, Wenli Zhang, Shuxun Wei, Shutong Zhang, Xiuli Zhu, Weiping Zhou, Jinmin Zhang, Hui Liu
Int. J. Biol. Sci. 2020; 16(16): 3210-3220. doi:10.7150/ijbs.46896
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
A novel miR-7156-3p-HOXD13 axis modulates glioma progression by regulating tumor cell stemness
Junfeng Zhang, Mengsheng Deng, Haipeng Tong, Wei Xue, Yu Guo, Jianmin Wang, Lizhao Chen, Shunan Wang
Int. J. Biol. Sci. 2020; 16(16): 3200-3209. doi:10.7150/ijbs.51293
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Histone deacetylase inhibitor MPT0B291 suppresses Glioma Growth in vitro and in vivo partially through acetylation of p53
Batsaikhan Buyandelger, Eli E Bar, Kuo-Sheng Hung, Ruei-Ming Chen, Yung-Hsiao Chiang, Jing-Ping Liou, Huei-Mei Huang, Jia-Yi Wang
Int. J. Biol. Sci. 2020; 16(16): 3184-3199. doi:10.7150/ijbs.45505
[Abstract] [Full text] [PDF]


toc.jpg

Review
Emerging Roles of SIRT1 in Alcoholic Liver Disease
Ruixue Ren, Ziming Wang, Miaomiao Wu, Hua Wang
Int. J. Biol. Sci. 2020; 16(16): 3174-3183. doi:10.7150/ijbs.49535
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis
Kun Hao, Wenjiao Jiang, Mengze Zhou, Hanwen Li, Yadong Chen, Fei Jiang, Qinghua Hu
Int. J. Biol. Sci. 2020; 16(16): 3163-3173. doi:10.7150/ijbs.46153
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Identification of a novel cancer stem cell subpopulation that promotes progression of human fatal renal cell carcinoma by single-cell RNA-seq analysis
Xiu-wu Pan, Hao Zhang, Da Xu, Jia-xin Chen, Wen-jin Chen, Si-shun Gan, Fa-jun Qu, Chuan-min Chu, Jian-wei Cao, Ying-hui Fan, Xu Song, Jian-qing Ye, Wang Zhou, Xin-gang Cui
Int. J. Biol. Sci. 2020; 16(16): 3149-3162. doi:10.7150/ijbs.46645
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Regulation of energy metabolism by combination therapy attenuates cardiac metabolic remodeling in heart failure
Yuting Huang, Kai Zhang, Miaomiao Jiang, Jingyu Ni, Jingrui Chen, Lan Li, Jie Deng, Yan Zhu, Jingyuan Mao, Xiumei Gao, Guanwei Fan
Int. J. Biol. Sci. 2020; 16(16): 3133-3148. doi:10.7150/ijbs.49520
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Dipeptidyl Peptidase-4 deficiency effectively protects the brain and neurological function in rodent after acute Hemorrhagic Stroke
Hon-Kan Yip, Mel S. Lee, Yi-Chen Li, Pei-Lin Shao, John Y. Chiang, Pei-Hsun Sung, Chien-Hui Yang, Kuan-Hung Chen
Int. J. Biol. Sci. 2020; 16(16): 3116-3132. doi:10.7150/ijbs.42677
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
NDRG2 ablation reprograms metastatic cancer cells towards glutamine dependence via the induction of ASCT2
Mingchao Ding, Xin Bu, Zhehao Li, Haokun Xu, Lin Feng, Junbi Hu, Xinxin Wei, Jiwei Gao, Yanyan Tao, Bolei Cai, Yanpu Liu, Xuan Qu, Liangliang Shen
Int. J. Biol. Sci. 2020; 16(16): 3100-3115. doi:10.7150/ijbs.48066
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Repression of FGF signaling is responsible for Dnmt3b inhibition and impaired de novo DNA methylation during early development of in vitro fertilized embryos
Wei Fu, Yuan Yue, Kai Miao, Guangyin Xi, Chao Zhang, Wenjuan Wang, Lei An, Jianhui Tian
Int. J. Biol. Sci. 2020; 16(15): 3085-3099. doi:10.7150/ijbs.51607
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response
Cui Jiang, Jingwei Liu, Min Guo, Xiaoxin Gao, Xuan Wu, Ning Bai, Wendong Guo, Na Li, Fei Yi, Rong Cheng, Hongde Xu, Tingting Zhou, Bo Jiang, Tao Sun, Shi Wei, Liu Cao
Int. J. Biol. Sci. 2020; 16(15): 3075-3084. doi:10.7150/ijbs.49735
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Monocytes enhance the inflammatory response to TLR2 stimulation in aortic valve interstitial cells through paracrine up-regulation of TLR2 level
Peijian Zhang, Erlinda The, Balachandar Nedumaran, Lihua Ao, Michael J. Jarrett, Dingli Xu, David A. Fullerton, Xianzhong Meng
Int. J. Biol. Sci. 2020; 16(15): 3062-3074. doi:10.7150/ijbs.49332
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Downregulation of MEG3 promotes neuroblastoma development through FOXO1-mediated autophagy and mTOR-mediated epithelial-mesenchymal transition
Mujie Ye, Hong Lu, Weitao Tang, Tianrui Jing, Shiyu Chen, Meng Wei, Jingjing Zhang, Jing Wang, Jing Ma, Duan Ma, Kuiran Dong
Int. J. Biol. Sci. 2020; 16(15): 3050-3061. doi:10.7150/ijbs.48126
[Abstract] [Full text] [PDF] [PubMed] [PMC]


toc.jpg

Research Paper
Multiple Developmental Defects in sox11a Mutant Zebrafish with Features of Coffin-Siris Syndrome
Shaoting Jia, Xingxing Wu, Yunya Wu, Xuefan Cui, Binbin Tao, Zuoyan Zhu, Wei Hu
Int. J. Biol. Sci. 2020; 16(15): 3039-3049. doi:10.7150/ijbs.47510
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Erratum
Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway: Erratum
Fei Han, Mei Xue, Yunpeng Chang, Xiaoyu Li, Yang Yang, Bei Sun, Liming Chen
Int. J. Biol. Sci. 2020; 16(15): 3037-3038. doi:10.7150/ijbs.53769
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Cover image
Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

new Latest impact factor 4.858 according to 2020 release of JCR®.

🆘 The global battle against SARS-CoV-2 and COVID-19: Special issue on Coronavirus disease https://www.ijbs.com/v16i10

Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Research Paper
Draft Genome Sequences for the Frankia sp. strains CgS1, CcI156 and CgMI4, Nitrogen-Fixing Bacteria Isolated from Casuarina sp. in Egypt
Samira Mansour, Erik Swanson, Céline Pesce, Stephen Simpson, Krystalynne Morris, W. Kelley Thomas, Louis S. Tisa
J. Genomics 2020; 8: 84-88. doi:10.7150/jgen.51181
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Nucleotide sequencing of the HoxA gene cluster using Gorilla fosmid clones
Takashi Kitano, Choong-Gon Kim, Naruya Saitou
J. Genomics 2020; 8: 80-83. doi:10.7150/jgen.50468
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Short Research Paper
Draft genome sequence of multi-resistant Salmonella enterica subsp. enterica serovar Rissen strain 19CS0416 isolated from Vietnam reveals mcr-1 plasmid mediated resistance to colistin already in 2013
Belen Gonzalez-Santamarina, Anne Busch, Silvia Garcia-Soto, Mostafa Y. Abdel-Glil, Jörg Linde, Reinhard Fries, Diana Meemken, Helmut Hotzel, Herbert Tomaso
J. Genomics 2020; 8: 76-79. doi:10.7150/jgen.42790
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Complete genome and plasmid sequences of a multidrug-resistant Salmonella enterica subsp. enterica serovar Panama isolate from a German cattle farm
Anne Busch, Helmut Hotzel, Ulrich Methner
J. Genomics 2020; 8: 71-75. doi:10.7150/jgen.48656
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details