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Review
Long Non-Coding RNAs: Potential Biomarkers and Targets for Hepatocellular Carcinoma Therapy and Diagnosis
Donghong Yuan, Yu Chen, Xiaobing Li, Jing Li, Yueshui Zhao, Jing Shen, Fukuan Du, Parham Jabbarzadeh Kaboli, Mingxing Li, Xu Wu, Huijiao Ji, Chi Hin Cho, Qinglian Wen, Wanping Li, Zhangang Xiao, Bo Chen
Int. J. Biol. Sci. 2021; 17(1): 220-235. doi:10.7150/ijbs.50730
[Abstract] [Full text] [PDF]


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Review
Biological characteristics of IL-6 and related intestinal diseases
Yuexin Guo, Boya Wang, Tiantian Wang, Lei Gao, Ze-jun Yang, Fei-fei Wang, Hong-wei Shang, Rongxuan Hua, Jing-dong Xu
Int. J. Biol. Sci. 2021; 17(1): 204-219. doi:10.7150/ijbs.51362
[Abstract] [Full text] [PDF]


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Research Paper
PRPF6 promotes androgen receptor/androgen receptor-variant 7 actions in castration-resistant prostate cancer cells
Wei Liu, Chunyu Wang, Shengli Wang, Kai Zeng, Shan Wei, Ning Sun, Ge Sun, Manlin Wang, Renlong Zou, Wensu Liu, Lin Lin, Huijuan Song, Zining Jin, Yue Zhao
Int. J. Biol. Sci. 2021; 17(1): 188-203. doi:10.7150/ijbs.50810
[Abstract] [Full text] [PDF]


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Research Paper
MYC dysfunction modulates stemness and tumorigenesis in breast cancer
Yiqiu Liu, Chengjun Zhu, Lin Tang, Qin Chen, Nan Guan, Kun Xu, Xiaoxiang Guan
Int. J. Biol. Sci. 2021; 17(1): 178-187. doi:10.7150/ijbs.51458
[Abstract] [Full text] [PDF]


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Review
Regulation of exosome production and cargo sorting
Hong Wei, Qi Chen, Li Lin, Chunli Sha, Taoqiong Li, Yueqin Liu, Xinming Yin, Yuhao Xu, Lu Chen, Wujiang Gao, Yuefeng Li, Xiaolan Zhu
Int. J. Biol. Sci. 2021; 17(1): 163-177. doi:10.7150/ijbs.53671
[Abstract] [Full text] [PDF]


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Research Paper
Ferroptosis in a sarcopenia model of senescence accelerated mouse prone 8 (SAMP8)
Yan Huang, Beiling Wu, Dingzhu Shen, Jiulin Chen, Zhihua Yu, Chuan Chen
Int. J. Biol. Sci. 2021; 17(1): 151-162. doi:10.7150/ijbs.53126
[Abstract] [Full text] [PDF]


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Review
The Emerging Roles of Autophagy-Related MicroRNAs in Cancer
Chan Shan, Xinzhe Chen, Hongjing Cai, Xiaodan Hao, Jing Li, Yinfeng Zhang, Jinning Gao, Zhixia Zhou, Xinmin Li, Cuiyun Liu, Peifeng Li, Kun Wang
Int. J. Biol. Sci. 2021; 17(1): 134-150. doi:10.7150/ijbs.50773
[Abstract] [Full text] [PDF]


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Review
Genome-to-phenome research in rats: progress and perspectives
Amy L. Zinski, Shane Carrion, Jennifer J. Michal, Maria A. Gartstein, Raymond M. Quock, Jon F. Davis, Zhihua Jiang
Int. J. Biol. Sci. 2021; 17(1): 119-133. doi:10.7150/ijbs.51628
[Abstract] [Full text] [PDF]


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Research Paper
Deciphering the genomic and lncRNA landscapes of aerobic glycolysis identifies potential therapeutic targets in pancreatic cancer
Li-Li Zhu, Zheng Wu, Rong-Kun Li, Xin Xing, Yong-Sheng Jiang, Jun Li, Ya-Hui Wang, Li-Peng Hu, Xu Wang, Wei-Ting Qin, Yong-Wei Sun, Zhi-Gang Zhang, Qin Yang, Shu-Heng Jiang
Int. J. Biol. Sci. 2021; 17(1): 107-118. doi:10.7150/ijbs.49243
[Abstract] [Full text] [PDF]


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Review
SARS-CoV-2 variants evolved during the early stage of the pandemic and effects of mutations on adaptation in Wuhan populations
Annoor Awadasseid, Yanling Wu, Yoshimasa Tanaka, Wen Zhang
Int. J. Biol. Sci. 2021; 17(1): 97-106. doi:10.7150/ijbs.47827
[Abstract] [Full text] [PDF]


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Review
The Regulatory Effect of SIRT1 on Extracellular Microenvironment Remodeling
Zhuo Wang, Wendong Guo, Fei Yi, Tingting Zhou, Xiaoman Li, Yanling Feng, Qiqiang Guo, Hongde Xu, Xiaoyu Song, Liu Cao
Int. J. Biol. Sci. 2021; 17(1): 89-96. doi:10.7150/ijbs.52619
[Abstract] [Full text] [PDF]


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Review
Role of hydrogen sulfide donors in cancer development and progression
Ebenezeri Erasto Ngowi, Attia Afzal, Muhammad Sarfraz, Saadullah Khattak, Shams Uz Zaman, Nazeer Hussain Khan, Tao Li, Qi-Ying Jiang, Xin Zhang, Shao-Feng Duan, Xin-Ying Ji, Dong-Dong Wu
Int. J. Biol. Sci. 2021; 17(1): 73-88. doi:10.7150/ijbs.47850
[Abstract] [Full text] [PDF]


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Review
A Multiple-Hit Hypothesis Involving Reactive Oxygen Species and Myeloperoxidase Explains Clinical Deterioration and Fatality in COVID-19
Pravin T Goud, David Bai, Husam M Abu-Soud
Int. J. Biol. Sci. 2021; 17(1): 62-72. doi:10.7150/ijbs.51811
[Abstract] [Full text] [PDF]


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Research Paper
Eomesodermin in CD4+T cells is essential for Ginkgolide K ameliorating disease progression in experimental autoimmune encephalomyelitis
Sheng Chen, Juan Zhang, Wen-Bo Yu, Jing-Cong Zhuang, Wei Xiao, Zhi-Ying Wu, Bao-Guo Xiao
Int. J. Biol. Sci. 2021; 17(1): 50-61. doi:10.7150/ijbs.50041
[Abstract] [Full text] [PDF]


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Review
βII spectrin (SPTBN1): biological function and clinical potential in cancer and other diseases
Panyu Yang, Yanyan Yang, Pin Sun, Yu Tian, Fang Gao, Chen Wang, Tingyu Zong, Min Li, Ying Zhang, Tao Yu, Zhirong Jiang
Int. J. Biol. Sci. 2021; 17(1): 32-49. doi:10.7150/ijbs.52375
[Abstract] [Full text] [PDF]


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Research Paper
ACE2 Correlated With Immune Infiltration Serves As A Novel Prognostic Biomarker In Clear Cell Renal Cell Carcinoma: Implication For COVID-19
Wuping Yang, Lei Li, Kenan Zhang, Kaifang Ma, Haibiao Xie, Yanqing Gong, Jingcheng Zhou, Kan Gong
Int. J. Biol. Sci. 2021; 17(1): 20-31. doi:10.7150/ijbs.51969
[Abstract] [Full text] [PDF]

Cover image
Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

new Latest impact factor 4.858 according to 2020 release of JCR®.

🆘 The global battle against SARS-CoV-2 and COVID-19: Special issue on Coronavirus disease https://www.ijbs.com/v16i10

Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Research Paper
Isolation, draft genome sequencing and identification of Enterobacter roggenkampii CCI9
Hironaga Akita, Yuya Itoiri, Noriyo Takeda, Zen-ichiro Kimura, Hiroyuki Inoue, Akinori Matsushika
J. Genomics 2021; 9: 1-5. doi:10.7150/jgen.46294
[Abstract] [Full text] [PDF]


Research Paper
Draft Genome Sequences for the Frankia sp. strains CgS1, CcI156 and CgMI4, Nitrogen-Fixing Bacteria Isolated from Casuarina sp. in Egypt
Samira Mansour, Erik Swanson, Céline Pesce, Stephen Simpson, Krystalynne Morris, W. Kelley Thomas, Louis S. Tisa
J. Genomics 2020; 8: 84-88. doi:10.7150/jgen.51181
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Nucleotide sequencing of the HoxA gene cluster using Gorilla fosmid clones
Takashi Kitano, Choong-Gon Kim, Naruya Saitou
J. Genomics 2020; 8: 80-83. doi:10.7150/jgen.50468
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Short Research Paper
Draft genome sequence of multi-resistant Salmonella enterica subsp. enterica serovar Rissen strain 19CS0416 isolated from Vietnam reveals mcr-1 plasmid mediated resistance to colistin already in 2013
Belen Gonzalez-Santamarina, Anne Busch, Silvia Garcia-Soto, Mostafa Y. Abdel-Glil, Jörg Linde, Reinhard Fries, Diana Meemken, Helmut Hotzel, Herbert Tomaso
J. Genomics 2020; 8: 76-79. doi:10.7150/jgen.42790
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details