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Research Paper
Identification of low-dose radiation-induced exosomal circ-METRN and miR-4709-3p/GRB14/PDGFRα pathway as a key regulatory mechanism in Glioblastoma progression and radioresistance: Functional validation and clinical theranostic significance
Xinxin Wang, Qinchen Cao, Yonggang Shi, Xiaolong Wu, Yin Mi, Ke Liu, Quancheng Kan, Ruitai Fan, Zhangsuo Liu, Mingzhi Zhang
Int. J. Biol. Sci. 2021; 17(4): 1061-1078. doi:10.7150/ijbs.57168
[Abstract] [Full text] [PDF]


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Research Paper
Theaflavin protects against oxalate calcium-induced kidney oxidative stress injury via upregulation of SIRT1
Tao Ye, Xiaoqi Yang, Haoran Liu, Peng Lv, Hongyan Lu, Kehua Jiang, Ejun Peng, Zhangqun Ye, Zhiqiang Chen, Kun Tang
Int. J. Biol. Sci. 2021; 17(4): 1050-1060. doi:10.7150/ijbs.57160
[Abstract] [Full text] [PDF]


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Review
Progress of Gastric Cancer Surgery in the era of Precision Medicine
Yumin Wang, Luyuan Zhang, Yi Yang, Shan Lu, Hao Chen
Int. J. Biol. Sci. 2021; 17(4): 1041-1049. doi:10.7150/ijbs.56735
[Abstract] [Full text] [PDF]


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Research Paper
Generation of VEGF knock-in Cashmere goat via the CRISPR/Cas9 system
Xiao Hu, Fei Hao, Xiaocong Li, Zhiyuan Xun, Yuan Gao, Bingxu Ren, Ming Cang, Hao Liang, Dongjun Liu
Int. J. Biol. Sci. 2021; 17(4): 1026-1040. doi:10.7150/ijbs.55559
[Abstract] [Full text] [PDF]


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Review
Extrachromosomal Circular DNAs: Origin, formation and emerging function in Cancer
Man Wang, Xinzhe Chen, Fei Yu, Han Ding, Yuan Zhang, Kun Wang
Int. J. Biol. Sci. 2021; 17(4): 1010-1025. doi:10.7150/ijbs.54614
[Abstract] [Full text] [PDF]


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Research Paper
Homoharringtonine inhibited breast cancer cells growth via miR-18a-3p/AKT/mTOR signaling pathway
Li-bin Wang, Dan-ni Wang, Li-gang Wu, Jia Cao, Jin-hai Tian, Rong Liu, Rong Ma, Jing-jing Yu, Jia Wang, Qi Huang, Wen-yong Xiong, Xu Zhang
Int. J. Biol. Sci. 2021; 17(4): 995-1009. doi:10.7150/ijbs.44907
[Abstract] [Full text] [PDF]


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Research Paper
Isochromanoindolenines suppress triple-negative breast cancer cell proliferation partially via inhibiting Akt activation
Xiaoyan Jiang, Xu Zhi, Peixia Zhang, Zhongmei Zhou, Jinxiang Ye, Yu Gao, Xinye Wang, Chuanyu Yang, Haijun Chen, Rong Liu, Ceshi Chen
Int. J. Biol. Sci. 2021; 17(4): 986-994. doi:10.7150/ijbs.48170
[Abstract] [Full text] [PDF]


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Research Paper
Circulating Exosomal miR-1-3p from Rats with Myocardial Infarction Plays a Protective Effect on Contrast-Induced Nephropathy via Targeting ATG13 and activating the AKT Signaling Pathway
Pengcheng Zhao, Yeqian Zhu, Ling Sun, Wenwu Zhu, Yao Lu, Jian Zhang, Yangming Mao, Qiushi Chen, Fengxiang Zhang
Int. J. Biol. Sci. 2021; 17(4): 972-985. doi:10.7150/ijbs.55887
[Abstract] [Full text] [PDF]


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Research Paper
Silencing PRSS1 suppresses the growth and proliferation of gastric carcinoma cells via the ERK pathway
Dongmei Ye, Yuxuan Li, Heliang Zhang, Zhiwei Zhou, Yujie Tang, Peng Wu, Qiang Zhao, Zhiwei Zhang
Int. J. Biol. Sci. 2021; 17(4): 957-971. doi:10.7150/ijbs.52591
[Abstract] [Full text] [PDF]


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Research Paper
Ferroptosis-related Genes for Overall Survival Prediction in Patients with Colorectal Cancer can be Inhibited by Gallic acid
Zongchao Hong, Peili Tang, Bo Liu, Chongwang Ran, Chong Yuan, Ying Zhang, Yi Lu, Xueyun Duan, Yanfang Yang, Hezhen Wu
Int. J. Biol. Sci. 2021; 17(4): 942-956. doi:10.7150/ijbs.57164
[Abstract] [Full text] [PDF]


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Research Paper
Macrophage contributes to radiation-induced anti-tumor abscopal effect on transplanted breast cancer by HMGB1/TNF-α signaling factors
Lin Zhu, Songling Hu, Qianping Chen, Haowen Zhang, Jiamei Fu, Yuchuan Zhou, Yang Bai, Yan Pan, Chunlin Shao
Int. J. Biol. Sci. 2021; 17(4): 926-941. doi:10.7150/ijbs.57445
[Abstract] [Full text] [PDF]


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Research Paper
FOXM1-induced miR-552 expression contributes to pancreatic cancer progression by targeting multiple tumor suppressor genes
Xiao Wang, Ning Dou, Jialin Wang, Yi Zhang, Yandong Li, Yong Gao
Int. J. Biol. Sci. 2021; 17(4): 915-925. doi:10.7150/ijbs.56733
[Abstract] [Full text] [PDF]


Erratum
A novel vehicle-like drug delivery 3D printing scaffold and its applications for a rat femoral bone repairing in vitro and in vivo: Erratum
Hui Wang, Zhengwei Deng, Jing Chen, Xin Qi, Libing Pang, Bocai Lin, Yan Teik Yuin Adib, Na Miao, Deping Wang, Yadong Zhang, Jiusheng Li, Xiangqiong Zeng
Int. J. Biol. Sci. 2021; 17(3): 913-914. doi:10.7150/ijbs.59031
[Abstract] [Full text] [PDF]


Erratum
The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer : Erratum
Wei Xu, Minghua Huang, Jia Guo, Huiting Zhang, Depeng Wang, Tiantian Liu, Haiting Liu, Shiming Chen, Peng Gao, Kun Mu
Int. J. Biol. Sci. 2021; 17(3): 911-912. doi:10.7150/ijbs.58372
[Abstract] [Full text] [PDF]


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Research Paper
Evaluation and characterization of HSPA5 (GRP78) expression profiles in normal individuals and cancer patients with COVID-19
Jiewen Fu, Chunli Wei, Jiayue He, Lianmei Zhang, Ju Zhou, Kyathegowdanadoddi Srinivasa Balaji, Shiyi Shen, Jiangzhou Peng, Amrish Sharma, Junjiang Fu
Int. J. Biol. Sci. 2021; 17(3): 897-910. doi:10.7150/ijbs.54055
[Abstract] [Full text] [PDF]


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Research Paper
Novel biomarkers for post-contrast acute kidney injury identified from long non-coding RNA expression profiles
Guanzhong Chen, Bowen Liu, Shiqun Chen, Huanqiang Li, Jin Liu, Ziling Mai, Enzhao Chen, Chunyun Zhou, Guoli Sun, Zhaodong Guo, Li Lei, Shanyi Huang, Liyao Zhang, Min Li, Ning Tan, Hong Li, Yulin Liao, Jia Liu, Jiyan Chen, Yong Liu
Int. J. Biol. Sci. 2021; 17(3): 882-896. doi:10.7150/ijbs.45294
[Abstract] [Full text] [PDF]

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau
Editor-in-Chief's Profile

new Latest impact factor 4.858 according to 2020 release of JCR®.

🆘 The global battle against SARS-CoV-2 and COVID-19: Special issue on Coronavirus disease https://www.ijbs.com/v16i10
Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Research Paper
Draft genome sequences of three filamentous cyanobacteria isolated from brackish habitats
Joanne Sarah Boden, Michele Grego, Henk Bolhuis, Patricia Sánchez-Baracaldo
J. Genomics 2021; 9: 20-25. doi:10.7150/jgen.53678
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Review
The Genetic Background of Central Serous Chorioretinopathy: A Review on Central Serous Chorioretinopathy Genes
Konstantinos Giannopoulos, Maria Gazouli, Klio Chatzistefanou, Anthi Bakouli, Marilita M Moschos
J. Genomics 2021; 9: 10-19. doi:10.7150/jgen.55545
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Draft Genome Sequence of Enterobacter sp. AS-1, a Potential Eurytrophic Recombination Host
Yuki Iwasaki, Yuya Itoiri, Sota Ihara, Hironaga Akita, Mamoru Oshiki, Zen-ichiro Kimura
J. Genomics 2021; 9: 6-9. doi:10.7150/jgen.53040
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Isolation, draft genome sequencing and identification of Enterobacter roggenkampii CCI9
Hironaga Akita, Yuya Itoiri, Noriyo Takeda, Zen-ichiro Kimura, Hiroyuki Inoue, Akinori Matsushika
J. Genomics 2021; 9: 1-5. doi:10.7150/jgen.46294
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details