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Research Paper
Effect of KNO3 on Lipid Synthesis and CaCO3 Accumulation in Pleurochrysis dentata Coccoliths with a Special Focus on Morphological Characters of Coccolithophores
Xuantong Chen, Ayyappa Kumar Sista Kameshwar, Chonlong Chio, Fan Lu, Wensheng Qin
Int. J. Biol. Sci. 2019; 15(13): 2844-2858. doi:10.7150/ijbs.35664
[Abstract] [Full text] [PDF]


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Research Paper
Altered Features of Vimentin-containing Cells in Cerebrum of Tg(SOD1*G93A)1Gur Mice: A Preliminary Study on Cerebrum Endogenous Neural Precursor Cells in Amyotrophic Lateral Sclerosis
Chunyan Tang, Lei Zhu, Qi Zhou, Menghua Li, Yu Zhu, Zhenzhen Xu, Yi Lu, Renshi Xu
Int. J. Biol. Sci. 2019; 15(13): 2830-2843. doi:10.7150/ijbs.33461
[Abstract] [Full text] [PDF]


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Research Paper
Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1α pathway in high-fat-diet-induced rats and insulin resistant cells
Liping Gu, Xiaoying Ding, Yufan Wang, Mingyu Gu, Jielei Zhang, Shuai Yan, Na Li, Zhiyi Song, Jiajing Yin, Leilei Lu, Yongde Peng
Int. J. Biol. Sci. 2019; 15(13): 2815-2829. doi:10.7150/ijbs.31781
[Abstract] [Full text] [PDF]


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Research Paper
Disrupted balance of CD4+ T-cell subsets in bone marrow of patients with primary immune thrombocytopenia
Qian Wang, Juan Li, Tian-shu Yu, Yu Liu, Kai Li, Shuang Liu, Yang Liu, Qi Feng, Lei Zhang, Guo-sheng Li, Lin-lin Shao, Jun Peng, Ming Hou, Xin-guang Liu
Int. J. Biol. Sci. 2019; 15(13): 2798-2814. doi:10.7150/ijbs.33779
[Abstract] [Full text] [PDF]


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Review
Cyclooxygenase-2 in Endometriosis
Zhen-Zhen Lai, Hui-Li Yang, Si-Yao Ha, Kai-Kai Chang, Jie Mei, We-Jie Zhou, Xue-Min Qiu, Xiao-Qiu Wang, Rui Zhu, Da-Jin Li, Ming-Qing Li
Int. J. Biol. Sci. 2019; 15(13): 2783-2797. doi:10.7150/ijbs.35128
[Abstract] [Full text] [PDF]


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Research Paper
Obstructive sleep apnea syndrome promotes the progression of aortic dissection via a ROS- HIF-1α-MMPs associated pathway
Wanjun Liu, Wenjun Zhang, Tao Wang, Jinhua Wu, Xiaodan Zhong, Kun Gao, Yujian Liu, Xingwei He, Yiwu Zhou, Hongjie Wang, Hesong Zeng
Int. J. Biol. Sci. 2019; 15(13): 2774-2782. doi:10.7150/ijbs.34888
[Abstract] [Full text] [PDF]


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Research Paper
Protein arginine methyltransferase 1 is required for maintenance of normal adult hematopoiesis
Lei Zhu, Xin He, Haojie Dong, Jie Sun, Hanying Wang, Yinghui Zhu, Feiteng Huang, Jingying Zou, Zexin Chen, Xiaoying Zhao, Ling Li
Int. J. Biol. Sci. 2019; 15(13): 2763-2773. doi:10.7150/ijbs.38859
[Abstract] [Full text] [PDF]


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Research Paper
MTERFD1 promotes cell growth and irradiation resistance in colorectal cancer by upregulating interleukin-6 and interleukin-11
Xiaoshuang Liu, Xiaopeng Cao, Cong Liu, Yi Cao, Quanquan Zhao, Xiaojie Tan, Xu Li, Xiaodong Xu, Enda Yu, Hao Wang
Int. J. Biol. Sci. 2019; 15(12): 2750-2762. doi:10.7150/ijbs.36916
[Abstract] [Full text] [PDF]


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Research Paper
CREB1/Lin28/miR-638/VASP Interactive Network Drives the Development of Breast Cancer
Peng-Chao Hu, Kai Li, Yi-Hao Tian, Wen-Ting Pan, Ying Wang, Xiao-Long Xu, Yan-Qi He, Yang Gao, Lei Wei, Jing-Wei Zhang
Int. J. Biol. Sci. 2019; 15(12): 2733-2749. doi:10.7150/ijbs.36854
[Abstract] [Full text] [PDF]


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Research Paper
Optimization Strategy for Generating Gene-edited Tibet Minipigs by Synchronized Oestrus and Cytoplasmic Microinjection
Bangzhu Chen, Peng Gu, Junshuang Jia, Wei Liu, Yumin Liu, Wen Liu, Tao Xu, Xiaolin Lin, Taoyan Lin, Yu Liu, Hengwei Chen, Mingchen Xu, Jin Yuan, Jianing Zhang, Yinghui Zhang, Dong Xiao, Weiwang Gu
Int. J. Biol. Sci. 2019; 15(12): 2719-2732. doi:10.7150/ijbs.35930
[Abstract] [Full text] [PDF]


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Research Paper
Healthy mitochondria inhibit the metastatic melanoma in lungs
Ailing Fu, Yixue Hou, Zhenyao Yu, Zizhen Zhao, Zesheng Liu
Int. J. Biol. Sci. 2019; 15(12): 2707-2718. doi:10.7150/ijbs.38104
[Abstract] [Full text] [PDF]


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Research Paper
RMP/URI inhibits both intrinsic and extrinsic apoptosis through different signaling pathways
Yuan Ji, Jian Shen, Min Li, Xiaoxiao Zhu, Yanyan Wang, Jiazheng Ding, Shunyao Jiang, Linqi Chen, Wenxiang Wei
Int. J. Biol. Sci. 2019; 15(12): 2692-2706. doi:10.7150/ijbs.36829
[Abstract] [Full text] [PDF]


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Research Paper
The PACAP-derived peptide MPAPO facilitates corneal wound healing by promoting corneal epithelial cell proliferation and trigeminal ganglion cell axon regeneration
Zixian Wang, Wailan Shan, Huixian Li, Jia Feng, Shiyin Lu, Biqian Ou, Min Ma, Yi Ma
Int. J. Biol. Sci. 2019; 15(12): 2676-2691. doi:10.7150/ijbs.35630
[Abstract] [Full text] [PDF]


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Research Paper
BmBlimp-1 gene encoding a C2H2 zinc finger protein is required for wing development in the silkworm Bombyx mori
Song-Yuan Wu, Xiao-Ling Tong, Chun-Lin Li, Xin Ding, Zhu-Lin Zhang, Chun-Yan Fang, Duan Tan, Hai Hu, Huai Liu, Fang-Yin Dai
Int. J. Biol. Sci. 2019; 15(12): 2664-2675. doi:10.7150/ijbs.34743
[Abstract] [Full text] [PDF]


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Research Paper
Gene signature predictive of hepatocellular carcinoma patient response to transarterial chemoembolization
Valerie Fako, Sean P. Martin, Yotsawat Pomyen, Anuradha Budhu, Jittiporn Chaisaingmongkol, Sophia Franck, Joyce Man-Fong Lee, Irene Oi-Lin Ng, Tan-To Cheung, Xiyang Wei, Niya Liu, Junfang Ji, Lei Zhao, Zhaogang Liu, Hu-Liang Jia, Zhao-You Tang, Lun-Xiu Qin, Roman Kloeckner, Jens Marquardt, Tim Greten, Xin Wei Wang
Int. J. Biol. Sci. 2019; 15(12): 2654-2663. doi:10.7150/ijbs.39534
[Abstract] [Full text] [PDF]


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Research Paper
Evaluation of the effects of sequence length and microsatellite instability on single-guide RNA activity and specificity
Changzhi Zhao, Yunlong Wang, Xiongwei Nie, Xiaosong Han, Hailong Liu, Guanglei Li, Gaojuan Yang, Jinxue Ruan, Yunlong Ma, Xinyun Li, Huijun Cheng, Shuhong Zhao, Yaping Fang, Shengsong Xie
Int. J. Biol. Sci. 2019; 15(12): 2641-2653. doi:10.7150/ijbs.37152
[Abstract] [Full text] [PDF]

Cover image

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

Impact factor is 4.067 according to 2019 release of Journal Citation Reports®.
new Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Research Paper
Genomic characterization of a pectinolytic isolate of Serratia oryzae isolated from lake water
Nicole Hugouvieux-Cotte-Pattat, Cécile Jacot-des-Combes, Jérôme Briolay
J. Genomics 2019; 7: 64-72. doi:10.7150/jgen.38365
[Abstract] [Full text] [PDF]


Short Research Paper
Whole Genome Sequence of Marinobacter salarius Strain SMR5, Shown to Promote Growth in its Diatom Host
Mats Töpel, Matthew I.M. Pinder, Oskar N. Johansson, Olga Kourtchenko, Anna Godhe, Adrian K. Clarke
J. Genomics 2019; 7: 60-63. doi:10.7150/jgen.39039
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
The Draft Genome of a Hydrogen-producing Cyanobacterium, Arthrospira platensis NIES-46
Shigekatsu Suzuki, Haruyo Yamaguchi, Masanobu Kawachi
J. Genomics 2019; 7: 56-59. doi:10.7150/jgen.38149
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Short Research Paper
Draft genome sequences for three unisolated Alnus-infective Frankia Sp+ strains, AgTrS, AiOr and AvVan, the first sequenced Frankia strains able to sporulate in-planta
Lorine Bethencourt, Florian Vautrin, Najwa Taib, Audrey Dubost, Lucia Castro-Garcia, Olivier Imbaud, Danis Abrouk, Pascale Fournier, Jérôme Briolay, Agnès Nguyen, Philippe Normand, Maria P. Fernandez, Céline Brochier-Armanet, Aude Herrera-Belaroussi
J. Genomics 2019; 7: 50-55. doi:10.7150/jgen.35875
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details