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Review
Immune Response and COVID-19: A mirror image of Sepsis
Eduardo López-Collazo, José Avendaño-Ortiz, Alejandro Martín-Quirós, Luis A. Aguirre
Int. J. Biol. Sci. 2020; 16(14): 2479-2489. doi:10.7150/ijbs.48400
[Abstract] [Full text] [PDF]


Commentary
Glucocorticoids save lives in COVID-19 patients
Chu-Xia Deng
Int. J. Biol. Sci. 2020; 16(13): 2477-2478. doi:10.7150/ijbs.49125
[Abstract] [Full text] [PDF]


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Research Paper
Bioinformatic Analysis of Correlation between Immune Infiltration and COVID-19 in Cancer Patients
Xin Huang, Chaobin He, Xin Hua, Anna Kan, Shuxin Sun, Jun Wang, Shengping Li
Int. J. Biol. Sci. 2020; 16(13): 2464-2476. doi:10.7150/ijbs.48639
[Abstract] [Full text] [PDF]


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Review
Role of Hippo-YAP1/TAZ pathway and its crosstalk in cardiac biology
Xiaoqing Chen, Wenchang Yuan, Yilang Li, Jiandong Luo, Ning Hou
Int. J. Biol. Sci. 2020; 16(13): 2454-2463. doi:10.7150/ijbs.47142
[Abstract] [Full text] [PDF]


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Review
Serine/arginine-rich splicing factors: the bridge linking alternative splicing and cancer
Xiang Zheng, Qiu Peng, Lujuan Wang, Xuemei Zhang, Lili Huang, Jia Wang, Zailong Qin
Int. J. Biol. Sci. 2020; 16(13): 2442-2453. doi:10.7150/ijbs.46751
[Abstract] [Full text] [PDF]


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Research Paper
A Novel Ferroptosis-related Gene Signature for Overall Survival Prediction in Patients with Hepatocellular Carcinoma
Jie-ying Liang, De-shen Wang, Hao-cheng Lin, Xiu-xing Chen, Hui Yang, Yun Zheng, Yu-hong Li
Int. J. Biol. Sci. 2020; 16(13): 2430-2441. doi:10.7150/ijbs.45050
[Abstract] [Full text] [PDF]


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Review
The Roles of Noncardiomyocytes in Cardiac Remodeling
Dan Yang, Han-Qing Liu, Fang-Yuan Liu, Nan Tang, Zhen Guo, Shu-Qing Ma, Peng An, Ming-Yu Wang, Hai-Ming Wu, Zheng Yang, Di Fan, Qi-Zhu Tang
Int. J. Biol. Sci. 2020; 16(13): 2414-2429. doi:10.7150/ijbs.47180
[Abstract] [Full text] [PDF]


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Review
Interleukin 22 in Liver Injury, Inflammation and Cancer
Ye Wu, Jie Min, Chang Ge, Jinping Shu, Di Tian, Yuan Yuan, Dian Zhou
Int. J. Biol. Sci. 2020; 16(13): 2405-2413. doi:10.7150/ijbs.38925
[Abstract] [Full text] [PDF]


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Research Paper
LEF1/Id3/HRAS axis promotes the tumorigenesis and progression of esophageal squamous cell carcinoma
Xinyu Wang, Yue Zhao, Xiang Fei, Qijue Lu, Yang Li, Yang Yuan, Chaojing Lu, Chunguang Li, Hezhong Chen
Int. J. Biol. Sci. 2020; 16(13): 2392-2404. doi:10.7150/ijbs.47035
[Abstract] [Full text] [PDF]


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Research Paper
Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels
Zhen Xiang, Jialin Liu, Dake Shi, Wei Chen, Jun Li, Ranlin Yan, Yufang Bi, Weiguo Hu, Zhenggang Zhu, Yingyan Yu, Zhitao Yang
Int. J. Biol. Sci. 2020; 16(13): 2382-2391. doi:10.7150/ijbs.47652
[Abstract] [Full text] [PDF]


Erratum
Andrographolide Suppress Tumor Growth by Inhibiting TLR4/NF-κB Signaling Activation in Insulinoma: Erratum
Qian-Qian Zhang, Yi Ding, Yan Lei, Cui-Ling Qi, Xiao-Dong He, Tian Lan, Jiang-Chao Li, Ping Gong, Xuesong Yang, Jian-Guo Geng, Li-Jing Wang
Int. J. Biol. Sci. 2020; 16(13): 2379-2381. doi:10.7150/ijbs.49433
[Abstract] [Full text] [PDF]


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Review
Kupffer Cells in Non-alcoholic Fatty Liver Disease: Friend or Foe?
Jiajia Chen, Xiaoyi Deng, Yongjian Liu, Qiuhua Tan, Guidong Huang, Qishi Che, Jiao Guo, Zhengquan Su
Int. J. Biol. Sci. 2020; 16(13): 2367-2378. doi:10.7150/ijbs.47143
[Abstract] [Full text] [PDF]


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Review
The Gut-liver Axis in Immune Remodeling: New insight into Liver Diseases
Xinyu Yang, Di Lu, Jianyong Zhuo, Zuyuan Lin, Modan Yang, Xiao Xu
Int. J. Biol. Sci. 2020; 16(13): 2357-2366. doi:10.7150/ijbs.46405
[Abstract] [Full text] [PDF]


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Research Paper
KLF6 Acetylation Promotes Sublytic C5b-9-Induced Production of MCP-1 and RANTES in Experimental Mesangial Proliferative Glomerulonephritis
Tianyi Yu, Yajuan Gong, Yu Liu, Lu Xia, Chenhui Zhao, Longfei Liu, Mengxiao Xie, Zhijiao Wu, Dan Zhao, Wen Qiu, Yingwei Wang, Jing Zhang, Mingde Ji
Int. J. Biol. Sci. 2020; 16(13): 2340-2356. doi:10.7150/ijbs.46573
[Abstract] [Full text] [PDF]


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Review
The Role of Interleukins in Colorectal Cancer
Jingjing Li, Ling Huang, Hanzhang Zhao, Yuheng Yan, Jing Lu
Int. J. Biol. Sci. 2020; 16(13): 2323-2339. doi:10.7150/ijbs.46651
[Abstract] [Full text] [PDF]


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Review
Bile acids mediated potential functional interaction between FXR and FATP5 in the regulation of Lipid Metabolism
Anita Kumari, Dharam Pal Pathak, Shailendra Asthana
Int. J. Biol. Sci. 2020; 16(13): 2308-2322. doi:10.7150/ijbs.44774
[Abstract] [Full text] [PDF]

Cover image
Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

new Latest impact factor 4.858 according to 2020 release of JCR®.

🆘 The global battle against SARS-CoV-2 and COVID-19: Special issue on Coronavirus disease https://www.ijbs.com/v16i10

Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Short Research Paper
Draft genome sequence of multi-resistant Salmonella enterica subsp. enterica serovar Rissen strain 19CS0416 isolated from Vietnam reveals mcr-1 plasmid mediated resistance to colistin already in 2013
Belen Gonzalez-Santamarina, Anne Busch, Silvia Garcia-Soto, Mostafa Y. Abdel-Glil, Jörg Linde, Reinhard Fries, Diana Meemken, Helmut Hotzel, Herbert Tomaso
J. Genomics 2020; 8: 76-79. doi:10.7150/jgen.42790
[Abstract] [Full text] [PDF]


Research Paper
Complete genome and plasmid sequences of a multidrug-resistant Salmonella enterica subsp. enterica serovar Panama isolate from a German cattle farm
Anne Busch, Helmut Hotzel, Ulrich Methner
J. Genomics 2020; 8: 71-75. doi:10.7150/jgen.48656
[Abstract] [Full text] [PDF]


Research Paper
crispRdesignR: A Versatile Guide RNA Design Package in R for CRISPR/Cas9 Applications
Dylan Beeber, Frédéric JJ Chain
J. Genomics 2020; 8: 62-70. doi:10.7150/jgen.41196
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Draft genome sequence of Actinomadura sp. K4S16 and elucidation of the nonthmicin biosynthetic pathway
Hisayuki Komaki, Enjuro Harunari, Natsuko Ichikawa, Akira Hosoyama, Moriyuki Hamada, Kannika Duangmal, Arinthip Thamchaipenet, Yasuhiro Igarashi
J. Genomics 2020; 8: 53-61. doi:10.7150/jgen.44650
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details