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Review
The Role of Inflammation in Age-Related Macular Degeneration
Wei Tan, Jingling Zou, Shigeo Yoshida, Bing Jiang, Yedi Zhou
Int. J. Biol. Sci. 2020; 16(15): 2989-3001. doi:10.7150/ijbs.49890
[Abstract] [Full text] [PDF]


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Research Paper
The small molecule PSSM0332 disassociates the CRL4ADCAF8 E3 ligase complex to decrease the ubiquitination of NcoR1 and inhibit the inflammatory response in a mouse sepsis-induced myocardial dysfunction model
Qingyun Peng, Huifen Xu, Mingbing Xiao, Linhua Wang
Int. J. Biol. Sci. 2020; 16(15): 2974-2988. doi:10.7150/ijbs.50186
[Abstract] [Full text] [PDF]


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Research Paper
RAB37 multiple alleles, transcription activation and evolution in mammals
Xu Xu, Mengxin Hu, Ruhong Ying, Juan Zou, Lan Lin, Hanhua Cheng, Rongjia Zhou
Int. J. Biol. Sci. 2020; 16(15): 2964-2973. doi:10.7150/ijbs.47959
[Abstract] [Full text] [PDF]


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Research Paper
IU1 suppresses proliferation of cervical cancer cells through MDM2 degradation
Liu Xu, Jing Wang, Xiaoning Yuan, Shuhua Yang, Xiaolong Xu, Kai Li, Yanqi He, Lei Wei, Jingwei Zhang, Yihao Tian
Int. J. Biol. Sci. 2020; 16(15): 2951-2963. doi:10.7150/ijbs.47999
[Abstract] [Full text] [PDF]


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Research Paper
Lnc-MCEI mediated the chemosensitivity of esophageal squamous cell carcinoma via miR-6759-5p to competitively regulate IGF2
Guangming Liu, Wei Guo, Guang Chen, Wencan Li, Youbin Cui, Junjie Qin, Jing Peng
Int. J. Biol. Sci. 2020; 16(15): 2938-2950. doi:10.7150/ijbs.47051
[Abstract] [Full text] [PDF]


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Research Paper
HPV E7 inhibits cell pyroptosis by promoting TRIM21-mediated degradation and ubiquitination of the IFI16 inflammasome
Yinjing Song, Xia Wu, Yaohan Xu, Jiang Zhu, Jiaying Li, Ziqi Zou, Luxia Chen, Boya Zhang, Chunting Hua, Han Rui, Qiaoli Zheng, Qiang Zhou, Qingqing Wang, Hao Cheng
Int. J. Biol. Sci. 2020; 16(15): 2924-2937. doi:10.7150/ijbs.50074
[Abstract] [Full text] [PDF]


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Review
Update of the current knowledge on genetics, evolution, immunopathogenesis, and transmission for coronavirus disease 19 (COVID-19)
Kalthoum Tizaoui, Ines Zidi, Keum Hwa Lee, Ramy Abou Ghayda, Sung Hwi Hong, Han Li, Lee Smith, Ai Koyanagi, Louis Jacob, Andreas Kronbichler, Jae Il Shin
Int. J. Biol. Sci. 2020; 16(15): 2906-2923. doi:10.7150/ijbs.48812
[Abstract] [Full text] [PDF]


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Research Paper
Disease knowledge and attitudes during the COVID-19 epidemic among international migrants in China: a national cross-sectional study
Cheng Wang, Qi Tian, Peizhen Zhao, Mingzhou Xiong, Carl A Latkin, Yiqun Gan, Brian J Hall, Bin Yang
Int. J. Biol. Sci. 2020; 16(15): 2895-2905. doi:10.7150/ijbs.47075
[Abstract] [Full text] [PDF]


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Research Paper
Dioscin facilitates ROS-induced apoptosis via the p38-MAPK/HSP27-mediated pathways in lung squamous cell carcinoma
Yinan Yao, Luyun Cui, Jiani Ye, Guangdie Yang, Guohua Lu, Xiaomei Fang, Zhu Zeng, Jianying Zhou
Int. J. Biol. Sci. 2020; 16(15): 2883-2894. doi:10.7150/ijbs.45710
[Abstract] [Full text] [PDF]


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Research Paper
Yin and Yang Regulation of Liver X Receptor α Signaling Control of Cholesterol Metabolism by Poly(ADP-ribose) polymerase 1
Fengxiao Zhang, Cheng Wang, Yuhan Jiang, Kun Huang, Fangmei Liu, Meng Du, Xi Luo, Dan Huang, Kai Huang
Int. J. Biol. Sci. 2020; 16(15): 2868-2882. doi:10.7150/ijbs.50042
[Abstract] [Full text] [PDF]


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Research Paper
miR-550-1 functions as a tumor suppressor in acute myeloid leukemia via the hippo signaling pathway
Chao Hu, Mengxia Yu, Chenying Li, Yungui Wang, Xia Li, Bryan Ulrich, Rui Su, Lei Dong, Hengyou Weng, Huilin Huang, Xi Jiang, Jianjun Chen, Jie Jin
Int. J. Biol. Sci. 2020; 16(15): 2853-2867. doi:10.7150/ijbs.44365
[Abstract] [Full text] [PDF]


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Research Paper
Rictor promotes cell migration and actin polymerization through regulating ABLIM1 phosphorylation in Hepatocellular Carcinoma
Xin Dong, Mei Feng, Hui Yang, Hengkang Liu, Hua Guo, Xianshu Gao, Yucun Liu, Rong Liu, Ning Zhang, Ruibing Chen, Ruirui Kong
Int. J. Biol. Sci. 2020; 16(15): 2835-2852. doi:10.7150/ijbs.46285
[Abstract] [Full text] [PDF]


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Research Paper
The development of the 'COVID-19 Psychological Resilience Model' and its efficacy during the COVID-19 pandemic in China
Zongling He, Jiajia Chen, Keliang Pan, Yuchuan Yue, Teris Cheung, Yin Yuan, Na Du, Yan Zhao, Yusu Feng, Die Zhou, You Zhou, Fengmei Lu, Yong Chen, Manxi He, Yu-Tao Xiang
Int. J. Biol. Sci. 2020; 16(15): 2828-2834. doi:10.7150/ijbs.50127
[Abstract] [Full text] [PDF]


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Research Paper
Oleate acid-stimulated HMMR expression by CEBPα is associated with nonalcoholic steatohepatitis and hepatocellular carcinoma
Deyu Zhang, Jiahong Liu, Tian Xie, Qiwei Jiang, Lihua Ding, Jianhua Zhu, Qinong Ye
Int. J. Biol. Sci. 2020; 16(15): 2812-2827. doi:10.7150/ijbs.49785
[Abstract] [Full text] [PDF]


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Review
COVID-19: Insight into the asymptomatic SARS-COV-2 infection and transmission
Dongsheng Han, Rui Li, Yanxi Han, Rui Zhang, Jinming Li
Int. J. Biol. Sci. 2020; 16(15): 2803-2811. doi:10.7150/ijbs.48991
[Abstract] [Full text] [PDF]


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Research Paper
Deletion of Mitochondrial Uncoupling Protein 2 Exacerbates Mitochondrial Damage in Mice Subjected to Cerebral Ischemia and Reperfusion Injury under both Normo- and Hyperglycemic Conditions
Maotao He, Yanmei Ma, Rui Wang, Jianzhong Zhang, Li Jing, P. Andy Li
Int. J. Biol. Sci. 2020; 16(15): 2788-2802. doi:10.7150/ijbs.48204
[Abstract] [Full text] [PDF]

Cover image
Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

new Latest impact factor 4.858 according to 2020 release of JCR®.

🆘 The global battle against SARS-CoV-2 and COVID-19: Special issue on Coronavirus disease https://www.ijbs.com/v16i10

Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Research Paper
Draft Genome Sequences for the Frankia sp. strains CgS1, CcI156 and CgMI4, Nitrogen-Fixing Bacteria Isolated from Casuarina sp. in Egypt
Samira Mansour, Erik Swanson, Céline Pesce, Stephen Simpson, Krystalynne Morris, W. Kelley Thomas, Louis S. Tisa
J. Genomics 2020; 8: 84-88. doi:10.7150/jgen.51181
[Abstract] [Full text] [PDF]


Research Paper
Nucleotide sequencing of the HoxA gene cluster using Gorilla fosmid clones
Takashi Kitano, Choong-Gon Kim, Naruya Saitou
J. Genomics 2020; 8: 80-83. doi:10.7150/jgen.50468
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Short Research Paper
Draft genome sequence of multi-resistant Salmonella enterica subsp. enterica serovar Rissen strain 19CS0416 isolated from Vietnam reveals mcr-1 plasmid mediated resistance to colistin already in 2013
Belen Gonzalez-Santamarina, Anne Busch, Silvia Garcia-Soto, Mostafa Y. Abdel-Glil, Jörg Linde, Reinhard Fries, Diana Meemken, Helmut Hotzel, Herbert Tomaso
J. Genomics 2020; 8: 76-79. doi:10.7150/jgen.42790
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Complete genome and plasmid sequences of a multidrug-resistant Salmonella enterica subsp. enterica serovar Panama isolate from a German cattle farm
Anne Busch, Helmut Hotzel, Ulrich Methner
J. Genomics 2020; 8: 71-75. doi:10.7150/jgen.48656
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details