Research Paper
Myokine Irisin promotes osteogenesis by activating BMP/SMAD signaling via αV integrin and regulates bone mass in mice
Yuan Xue, Sihan Hu, Chichi Chen, Jiachen He, Jie Sun, Yesheng Jin, Yuanshu Zhang, Guoqing Zhu, Qin Shi, Yongjun Rui
Int. J. Biol. Sci. 2022; 18(2): 572-584. doi:10.7150/ijbs.63505
[Abstract] [Full text] [PDF]

Review
Advanced high resolution three-dimensional imaging to visualize the cerebral neurovascular network in stroke
Chudai Zeng, Zhuohui Chen, Haojun Yang, Yishu Fan, Lujing Fei, Xinghang Chen, Mengqi Zhang
Int. J. Biol. Sci. 2022; 18(2): 552-571. doi:10.7150/ijbs.64373
[Abstract] [Full text] [PDF]

Review
The Landscape Of Alpha Fetoprotein In Hepatocellular Carcinoma: Where Are We?
Xin Hu, Ronggao Chen, Qiang Wei, Xiao Xu
Int. J. Biol. Sci. 2022; 18(2): 536-551. doi:10.7150/ijbs.64537
[Abstract] [Full text] [PDF]

Research Paper
LncRNA FAM83A-AS1 facilitates tumor proliferation and the migration via the HIF-1α/ glycolysis axis in lung adenocarcinoma
Zhencong Chen, Zhengyang Hu, Qihai Sui, Yiwei Huang, Mengnan Zhao, Ming Li, Jiaqi Liang, Tao Lu, Cheng Zhan, Zongwu Lin, Fenghao Sun, Qun Wang, Lijie Tan
Int. J. Biol. Sci. 2022; 18(2): 522-535. doi:10.7150/ijbs.67556
[Abstract] [Full text] [PDF]

Research Paper
HPV E6/E7 promotes aerobic glycolysis in cervical cancer by regulating IGF2BP2 to stabilize m⁶A-MYC expression
Chenchen Hu, Tianyue Liu, Chenying Han, Yuxin Xuan, Dongbo Jiang, Yuanjie Sun, Xiyang Zhang, Wenxin Zhang, Yiming Xu, Yang Liu, Jingyu Pan, Jing Wang, Jiangjiang Fan, Yinggang Che, Yinan Huang, Jiaxing Zhang, Jiaqi Ding, Shuya Yang, Kun Yang
Int. J. Biol. Sci. 2022; 18(2): 507-521. doi:10.7150/ijbs.67770
[Abstract] [Full text] [PDF]

Research Paper
As a Novel Tumor Suppressor, LHPP Promotes Apoptosis by Inhibiting the PI3K/AKT Signaling Pathway in Oral Squamous Cell Carcinoma
Shanshan Liu, Wenzhen Gao, Yupu Lu, Qin Zhou, Rongjian Su, Tomoka Hasegawa, Juan Du, Minqi Li
Int. J. Biol. Sci. 2022; 18(2): 491-506. doi:10.7150/ijbs.66841
[Abstract] [Full text] [PDF]

Research Paper
ID09, A Newly-Designed Tubulin Inhibitor, Regulating the Proliferation, Migration, EMT Process and Apoptosis of Oral Squamous Cell Carcinoma
Qiushi Feng, Panpan Yang, He Wang, Congshan Li, Tomoka Hasegawa, Zhaopeng Liu, Minqi Li
Int. J. Biol. Sci. 2022; 18(2): 473-490. doi:10.7150/ijbs.65824
[Abstract] [Full text] [PDF]

Review
Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy
Yizhou Jiang, Limor Rubin, Tangming Peng, Linlin Liu, Xingan Xing, Philip Lazarovici, Wenhua Zheng
Int. J. Biol. Sci. 2022; 18(2): 459-472. doi:10.7150/ijbs.59272
[Abstract] [Full text] [PDF]

Research Paper
Minocycline improves the functional recovery after traumatic brain injury via inhibition of aquaporin-4
Qi Lu, Jun Xiong, Yuan Yuan, Zhanwei Ruan, Yu Zhang, Bo Chai, Lei Li, Shufang Cai, Jian Xiao, Yanqing Wu, Peng Huang, Hongyu Zhang
Int. J. Biol. Sci. 2022; 18(1): 441-458. doi:10.7150/ijbs.64187
[Abstract] [Full text] [PDF]

Research Paper
Engineering of human mesenchymal stem cells resistant to multiple natural killer subtypes
Dejin Zheng, Xiaoyan Wang, Zhenwu Zhang, Enqin Li, Cheungkwan Yeung, Roma Borkar, Guihui Qin, Yaojiong Wu, Ren-He Xu
Int. J. Biol. Sci. 2022; 18(1): 426-440. doi:10.7150/ijbs.64640
[Abstract] [Full text] [PDF]

Research Paper
DNA Polymerase Gamma Recovers Mitochondrial Function and Inhibits Vascular Calcification by Interacted with p53
Pengbo Wang, Boquan Wu, Shilong You, Saien Lu, Shengjun Xiong, Yuanming Zou, Pengyu Jia, Xiaofan Guo, Ying Zhang, Liu Cao, Yingxian Sun, Naijin Zhang
Int. J. Biol. Sci. 2022; 18(1): 409-425. doi:10.7150/ijbs.65030
[Abstract] [Full text] [PDF]

Review
COVID-19: systemic pathology and its implications for therapy
Qi Shen, Jie Li, Zhan Zhang, Shuang Guo, Qiuhong Wang, Xiaorui An, Haocai Chang
Int. J. Biol. Sci. 2022; 18(1): 386-408. doi:10.7150/ijbs.65911
[Abstract] [Full text] [PDF]

Research Paper
Enhanced Intracellular Reactive Oxygen Species by Photodynamic Therapy Effectively Promotes Chemoresistant Cell Death
Xiaolin Xu, Chenglong Wang, Peipei Zhang, Xuzhu Gao, Wencai Guan, Fanchen Wang, Xin Li, Jia Yuan, Hongjing Dou, Guoxiong Xu
Int. J. Biol. Sci. 2022; 18(1): 374-385. doi:10.7150/ijbs.66602
[Abstract] [Full text] [PDF]

Research Paper
Integrated Machine Learning and Bioinformatic Analyses Constructed a Novel Stemness-Related Classifier to Predict Prognosis and Immunotherapy Responses for Hepatocellular Carcinoma Patients
Dongjie Chen, Jixing Liu, Longjun Zang, Tijun Xiao, Xianlin Zhang, Zheng Li, Hongwei Zhu, Wenzhe Gao, Xiao Yu
Int. J. Biol. Sci. 2022; 18(1): 360-373. doi:10.7150/ijbs.66913
[Abstract] [Full text] [PDF]

Research Paper
ITGB4 deficiency induces mucus hypersecretion by upregulating MUC5AC in RSV-infected airway epithelial cells
Xizi Du, Yu Yang, Ming Yang, Lin Yuan, Leyuan Wang, Mengping Wu, Kai Zhou, Wenkai Li, Yang Xiang, Xiangping Qu, Huijun Liu, Xiaoqun Qin, Chi Liu
Int. J. Biol. Sci. 2022; 18(1): 349-359. doi:10.7150/ijbs.66215
[Abstract] [Full text] [PDF]

Research Paper
MMP-10 from M1 macrophages promotes pulmonary vascular remodeling and pulmonary arterial hypertension
Pei-Ling Chi, Chin-Chang Cheng, Cheng-Chung Hung, Mei-Tzu Wang, Hsien-Yueh Liu, Meng-Wei Ke, Min-Ci Shen, Kun-Chang Lin, Shu-Hung Kuo, Pin-Pen Hsieh, Shue-Ren Wann, Wei-Chun Huang
Int. J. Biol. Sci. 2022; 18(1): 331-348. doi:10.7150/ijbs.66472
[Abstract] [Full text] [PDF]

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