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Research Paper
Up-regulation of RNA Binding Proteins Contributes to Folate Deficiency-Induced Neural Crest Cells Dysfunction
Wenbo Liu, Kang Wang, Xiaoyan Lv, Qian Wang, Xiu Li, Zhigang Yang, Xia Liu, Li Yan, Xin Fu, Ran Xiao
Int. J. Biol. Sci. 2020; 16(1): 85-98. doi:10.7150/ijbs.33976
[Abstract] [Full text] [PDF]


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Research Paper
Metformin induces cell cycle arrest, apoptosis and autophagy through ROS/JNK signaling pathway in human osteosarcoma
Bo Li, Pingting Zhou, Kehan Xu, Tianrui Chen, Jian Jiao, Haifeng Wei, Xinghai Yang, Wei Xu, Wei Wan, Jianru Xiao
Int. J. Biol. Sci. 2020; 16(1): 74-84. doi:10.7150/ijbs.33787
[Abstract] [Full text] [PDF]


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Research Paper
Identification and characterization of chemical components in the bioactive fractions of Cynomorium coccineum that possess anticancer activity
Xiangmin Li, Mouna Sdiri, Juanjuan Peng, Yizhen Xie, Burton B Yang
Int. J. Biol. Sci. 2020; 16(1): 61-73. doi:10.7150/ijbs.38475
[Abstract] [Full text] [PDF]


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Research Paper
PM2.5 exposure induces vascular dysfunction via NO generated by iNOS in lung of ApoE-/- mouse
Min-Hui Long, Xiao-Ming Zhu, Qin Wang, Yao Chen, Xiang-Dong Gan, Fei Li, Wen-Liang Fu, Wei-Wei Xing, Dong-Qun Xu, Dong-Gang Xu
Int. J. Biol. Sci. 2020; 16(1): 49-60. doi:10.7150/ijbs.36073
[Abstract] [Full text] [PDF]


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Review
The Function of Pre-mRNA Alternative Splicing in Mammal Spermatogenesis
Huibin Song, Ling Wang, Dake Chen, Fenge Li
Int. J. Biol. Sci. 2020; 16(1): 38-48. doi:10.7150/ijbs.34422
[Abstract] [Full text] [PDF]


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Review
Publication Trends of Research on Sepsis and Host Immune Response during 1999-2019: A 20-year Bibliometric Analysis
Ren-qi Yao, Chao Ren, Jun-nan Wang, Guo-sheng Wu, Xiao-mei Zhu, Zhao-fan Xia, Yong-ming Yao
Int. J. Biol. Sci. 2020; 16(1): 27-37. doi:10.7150/ijbs.37496
[Abstract] [Full text] [PDF]


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Research Paper
Andrographolide Protects Against Adverse Cardiac Remodeling After Myocardial Infarction through Enhancing Nrf2 Signaling Pathway
Saiyang Xie, Wei Deng, Jiaojiao Chen, Qing-Qing Wu, Hongjian Li, Juan Wang, Li Wei, Chen Liu, Mingxia Duan, Zhulan Cai, Qingwen Xie, Tongtong Hu, Xiaofeng Zeng, Qizhu Tang
Int. J. Biol. Sci. 2020; 16(1): 12-26. doi:10.7150/ijbs.37269
[Abstract] [Full text] [PDF]


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Research Paper
LncARSR sponges miR-129-5p to promote proliferation and metastasis of bladder cancer cells through increasing SOX4 expression
Chunxian Liao, Zhaolin Long, Xinji Zhang, Jianli Cheng, Fuming Qi, Shihao Wu, Tao Huang
Int. J. Biol. Sci. 2020; 16(1): 1-11. doi:10.7150/ijbs.39461
[Abstract] [Full text] [PDF]


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Research Paper
MiR-4319 induced an inhibition of epithelial-mesenchymal transition and prevented cancer stemness of HCC through targeting FOXQ1
Shaoshan Han, Yu Shi, Liankang Sun, Zhikui Liu, Tao Song, Qingguang Liu
Int. J. Biol. Sci. 2019; 15(13): 2936-2947. doi:10.7150/ijbs.38000
[Abstract] [Full text] [PDF]


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Research Paper
Exosomal MicroRNA-155 Inhibits Enterovirus A71 Infection by Targeting PICALM
Jing Wu, Jiaqi Gu, Li Shen, Daihua Fang, Xinran Zou, Yuwen Cao, Shengjun Wang, Lingxiang Mao
Int. J. Biol. Sci. 2019; 15(13): 2925-2935. doi:10.7150/ijbs.36388
[Abstract] [Full text] [PDF]


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Research Paper
GBDTCDA: Predicting circRNA-disease Associations Based on Gradient Boosting Decision Tree with Multiple Biological Data Fusion
Xiujuan Lei, Zengqiang Fang
Int. J. Biol. Sci. 2019; 15(13): 2911-2924. doi:10.7150/ijbs.33806
[Abstract] [Full text] [PDF]


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Research Paper
Sphingolipidomic Analysis of C. elegans reveals Development- and Environment-dependent Metabolic Features
Xiaoxiang Cheng, Xue Jiang, Kin Yip Tam, Gang Li, Jun Zheng, Hongjie Zhang
Int. J. Biol. Sci. 2019; 15(13): 2897-2910. doi:10.7150/ijbs.30499
[Abstract] [Full text] [PDF]


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Research Paper
LncRNA SLCO4A1-AS1 predicts poor prognosis and promotes proliferation and metastasis via the EGFR/MAPK pathway in colorectal cancer
Rui Tang, Junhong Chen, Mengtian Tang, Zhiqiang Liao, Lianqing Zhou, Jiarui Jiang, Yingbin Hu, QianJin Liao, Wei Xiong, Yanyan Tang, Shaolin Nie
Int. J. Biol. Sci. 2019; 15(13): 2885-2896. doi:10.7150/ijbs.38041
[Abstract] [Full text] [PDF]


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Research Paper
Hydrogen sulfide treatment alleviated ventilator-induced lung injury through regulation of autophagy and endoplasmic reticulum stress
Xiaoli Ge, Jian Sun, Aihua Fei, Chengjin Gao, Shuming Pan, Zengbin Wu
Int. J. Biol. Sci. 2019; 15(13): 2872-2884. doi:10.7150/ijbs.38315
[Abstract] [Full text] [PDF]


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Research Paper
Macrophage Colony-stimulating Factor Mediates the Recruitment of Macrophages in Triple negative Breast Cancer
Xiaoqing Lu, Rui Yang, Lichao Zhang, Yanfeng Xi, Jiping Zhao, Fusheng Wang, Huanhu Zhang, Zhuoyu Li
Int. J. Biol. Sci. 2019; 15(13): 2859-2871. doi:10.7150/ijbs.39063
[Abstract] [Full text] [PDF]


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Research Paper
Effect of KNO3 on Lipid Synthesis and CaCO3 Accumulation in Pleurochrysis dentata Coccoliths with a Special Focus on Morphological Characters of Coccolithophores
Xuantong Chen, Ayyappa Kumar Sista Kameshwar, Chonlong Chio, Fan Lu, Wensheng Qin
Int. J. Biol. Sci. 2019; 15(13): 2844-2858. doi:10.7150/ijbs.35664
[Abstract] [Full text] [PDF]

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

Impact factor is 4.067 according to 2019 release of Journal Citation Reports®.
new Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Research Paper
Genomic characterization of a pectinolytic isolate of Serratia oryzae isolated from lake water
Nicole Hugouvieux-Cotte-Pattat, Cécile Jacot-des-Combes, Jérôme Briolay
J. Genomics 2019; 7: 64-72. doi:10.7150/jgen.38365
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Short Research Paper
Whole Genome Sequence of Marinobacter salarius Strain SMR5, Shown to Promote Growth in its Diatom Host
Mats Töpel, Matthew I.M. Pinder, Oskar N. Johansson, Olga Kourtchenko, Anna Godhe, Adrian K. Clarke
J. Genomics 2019; 7: 60-63. doi:10.7150/jgen.39039
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
The Draft Genome of a Hydrogen-producing Cyanobacterium, Arthrospira platensis NIES-46
Shigekatsu Suzuki, Haruyo Yamaguchi, Masanobu Kawachi
J. Genomics 2019; 7: 56-59. doi:10.7150/jgen.38149
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Short Research Paper
Draft genome sequences for three unisolated Alnus-infective Frankia Sp+ strains, AgTrS, AiOr and AvVan, the first sequenced Frankia strains able to sporulate in-planta
Lorine Bethencourt, Florian Vautrin, Najwa Taib, Audrey Dubost, Lucia Castro-Garcia, Olivier Imbaud, Danis Abrouk, Pascale Fournier, Jérôme Briolay, Agnès Nguyen, Philippe Normand, Maria P. Fernandez, Céline Brochier-Armanet, Aude Herrera-Belaroussi
J. Genomics 2019; 7: 50-55. doi:10.7150/jgen.35875
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details