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Review
From impossible to possible: the lessons from the control of recent COVID-19 outbreaks in China
Lixin Tai, Kengieng Wong, Li Wang, Li-jun Di
Int. J. Biol. Sci. 2021; 17(6): 1600-1612. doi:10.7150/ijbs.58906
[Abstract] [Full text] [PDF]


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Review
Global landscape of patents related to human coronaviruses
Kunmeng Liu, Zixuan Gu, Md Sahidul Islam, Thomas Scherngell, Xiangjun Kong, Jing Zhao, Xin Chen, Yuanjia Hu
Int. J. Biol. Sci. 2021; 17(6): 1588-1599. doi:10.7150/ijbs.58807
[Abstract] [Full text] [PDF]


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Review
Artificial intelligence in the diagnosis of COVID-19: challenges and perspectives
Shigao Huang, Jie Yang, Simon Fong, Qi Zhao
Int. J. Biol. Sci. 2021; 17(6): 1581-1587. doi:10.7150/ijbs.58855
[Abstract] [Full text] [PDF]


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Review
Construction and applications of SARS-CoV-2 pseudoviruses: a mini review
Minghai Chen, Xian-En Zhang
Int. J. Biol. Sci. 2021; 17(6): 1574-1580. doi:10.7150/ijbs.59184
[Abstract] [Full text] [PDF]


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Research Paper
Krebs Von den Lungen-6 as a predictive indicator for the risk of secondary pulmonary fibrosis and its reversibility in COVID-19 patients
Mingshan Xue, Teng Zhang, Hao Chen, Yifeng Zeng, Runpei Lin, Yingjie Zhen, Ning Li, Zhifeng Huang, Haisheng Hu, Luqian Zhou, Hui Wang, Xiaohua Douglas Zhang, Baoqing Sun
Int. J. Biol. Sci. 2021; 17(6): 1565-1573. doi:10.7150/ijbs.58825
[Abstract] [Full text] [PDF]


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Research Paper
In silico structure-based discovery of a SARS-CoV-2 main protease inhibitor
Lei Wen, Kaiming Tang, Kenn Ka-Heng Chik, Chris Chun-Yiu Chan, Jessica Oi-Ling Tsang, Ronghui Liang, Jianli Cao, Yaoqiang Huang, Cuiting Luo, Jian-Piao Cai, Zi-Wei Ye, Feifei Yin, Hin Chu, Dong-Yan Jin, Kwok-Yung Yuen, Shuofeng Yuan, Jasper Fuk-Woo Chan
Int. J. Biol. Sci. 2021; 17(6): 1555-1564. doi:10.7150/ijbs.59191
[Abstract] [Full text] [PDF]


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Research Paper
SARS-CoV-2 main protease suppresses type I interferon production by preventing nuclear translocation of phosphorylated IRF3
Sin-Yee Fung, Kam-Leung Siu, Huayue Lin, Man Lung Yeung, Dong-Yan Jin
Int. J. Biol. Sci. 2021; 17(6): 1547-1554. doi:10.7150/ijbs.59943
[Abstract] [Full text] [PDF]


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Review
Hydroxychloroquine/Chloroquine as Therapeutics for COVID-19: Truth under the Mystery
Yao Chen, Mei-Xiu Li, Guo-Dong Lu, Han-Ming Shen, Jing Zhou
Int. J. Biol. Sci. 2021; 17(6): 1538-1546. doi:10.7150/ijbs.59547
[Abstract] [Full text] [PDF]


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Review
Glucocorticoids are double-edged sword in the treatment of COVID-19 and cancers
Ruixin Yang, Yingyan Yu
Int. J. Biol. Sci. 2021; 17(6): 1530-1537. doi:10.7150/ijbs.58695
[Abstract] [Full text] [PDF]


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Research Paper
Developing effective siRNAs to reduce the expression of key viral genes of COVID-19
Renfei Wu, Kathy Qian Luo
Int. J. Biol. Sci. 2021; 17(6): 1521-1529. doi:10.7150/ijbs.59151
[Abstract] [Full text] [PDF]


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Review
The role of CD4+FoxP3+ regulatory T cells in the immunopathogenesis of COVID-19: implications for treatment
Yifei Wang, Jingbin Zheng, Md Sahidul Islam, Yang Yang, Yuanjia Hu, Xin Chen
Int. J. Biol. Sci. 2021; 17(6): 1507-1520. doi:10.7150/ijbs.59534
[Abstract] [Full text] [PDF]


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Review
Inflammatory stress in SARS-COV-2 associated Acute Kidney Injury
Junzhe Chen, Wenbiao Wang, Ying Tang, Xiao-ru Huang, Xueqing Yu, Hui-Yao Lan
Int. J. Biol. Sci. 2021; 17(6): 1497-1506. doi:10.7150/ijbs.58791
[Abstract] [Full text] [PDF]


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Review
Development and application of therapeutic antibodies against COVID-19
Lin Ning, Hamza B. Abagna, Qianhu Jiang, Siqi Liu, Jian Huang
Int. J. Biol. Sci. 2021; 17(6): 1486-1496. doi:10.7150/ijbs.59149
[Abstract] [Full text] [PDF]


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Review
The Genetic Variant of SARS-CoV-2: Would it matter for Controlling the Devastating Pandemic?
Shuxin Guo, Kefang Liu, Jun Zheng
Int. J. Biol. Sci. 2021; 17(6): 1476-1485. doi:10.7150/ijbs.59137
[Abstract] [Full text] [PDF]


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Research Paper
Attitudes toward COVID-19 vaccines in Chinese college students
Wei Bai, Hong Cai, Shou Liu, Huanzhong Liu, Han Qi, Xu Chen, Rui Liu, Teris Cheung, Zhaohui Su, Chee H. Ng, Yu-Tao Xiang
Int. J. Biol. Sci. 2021; 17(6): 1469-1475. doi:10.7150/ijbs.58835
[Abstract] [Full text] [PDF]


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Review
Review of Covid-19 vaccine clinical trials - A puzzle with missing pieces
Hang Fai Kwok
Int. J. Biol. Sci. 2021; 17(6): 1461-1468. doi:10.7150/ijbs.59170
[Abstract] [Full text] [PDF]

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

new Latest impact factor 4.858 according to 2020 release of JCR®.

new🆘The continued global battle against SARS-CoV-2 and COVID-19: Special issue on Coronavirus disease https://www.ijbs.com/v17i6

🆘 The global battle against SARS-CoV-2 and COVID-19: Special issue on Coronavirus disease https://www.ijbs.com/v16i10

Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Research Paper
Draft genome sequences of three filamentous cyanobacteria isolated from brackish habitats
Joanne Sarah Boden, Michele Grego, Henk Bolhuis, Patricia Sánchez-Baracaldo
J. Genomics 2021; 9: 20-25. doi:10.7150/jgen.53678
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Review
The Genetic Background of Central Serous Chorioretinopathy: A Review on Central Serous Chorioretinopathy Genes
Konstantinos Giannopoulos, Maria Gazouli, Klio Chatzistefanou, Anthi Bakouli, Marilita M Moschos
J. Genomics 2021; 9: 10-19. doi:10.7150/jgen.55545
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Draft Genome Sequence of Enterobacter sp. AS-1, a Potential Eurytrophic Recombination Host
Yuki Iwasaki, Yuya Itoiri, Sota Ihara, Hironaga Akita, Mamoru Oshiki, Zen-ichiro Kimura
J. Genomics 2021; 9: 6-9. doi:10.7150/jgen.53040
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Isolation, draft genome sequencing and identification of Enterobacter roggenkampii CCI9
Hironaga Akita, Yuya Itoiri, Noriyo Takeda, Zen-ichiro Kimura, Hiroyuki Inoue, Akinori Matsushika
J. Genomics 2021; 9: 1-5. doi:10.7150/jgen.46294
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details