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Review
The role of RNA m5C modification in cancer metastasis
Qiaofeng Zhang, Furong Liu, Wei Chen, Hongrui Miao, Huifang Liang, Zhibin Liao, Zhanguo Zhang, Bixiang Zhang
Int. J. Biol. Sci. 2021; 17(13): 3369-3380. doi:10.7150/ijbs.61439
[Abstract] [Full text] [PDF]


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Review
Crucial Roles of microRNA-Mediated Autophagy in Urologic Malignancies
Maolei Shen, Xin Li, Biao Qian, Qiang Wang, Shanan Lin, Wenhao Wu, Shuai Zhu, Rui Zhu, Shankun Zhao
Int. J. Biol. Sci. 2021; 17(13): 3356-3368. doi:10.7150/ijbs.61175
[Abstract] [Full text] [PDF]


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Research Paper
Downregulation of miR‑214-3p attenuates mesangial hypercellularity by targeting PTEN‑mediated JNK/c-Jun signaling in IgA nephropathy
Yan Li, Ming Xia, Liang Peng, Haiyang Liu, Guochun Chen, Chang Wang, Du Yuan, Yu Liu, Hong Liu
Int. J. Biol. Sci. 2021; 17(13): 3343-3355. doi:10.7150/ijbs.61274
[Abstract] [Full text] [PDF]


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Research Paper
Deubiquitinase PSMD7 promotes the proliferation, invasion, and cisplatin resistance of gastric cancer cells by stabilizing RAD23B
Jianjiang Wang, Runkun Liu, Huanye Mo, Xuelian Xiao, Qiuran Xu, Wei Zhao
Int. J. Biol. Sci. 2021; 17(13): 3331-3342. doi:10.7150/ijbs.61128
[Abstract] [Full text] [PDF]


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Research Paper
NEDD4L-induced β-catenin ubiquitination suppresses the formation and progression of interstitial pulmonary fibrosis via inhibiting the CTHRC1/HIF-1α axis
Lin Chen, Yang Yang, Haiying Yan, Xiaying Peng, Jun Zou
Int. J. Biol. Sci. 2021; 17(13): 3320-3330. doi:10.7150/ijbs.57247
[Abstract] [Full text] [PDF]


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Research Paper
RS-5645 attenuates inflammatory cytokine storm induced by SARS-CoV-2 spike protein and LPS by modulating pulmonary microbiota
Te Liu, Jianchao Wu, Changpeng Han, Zhangbin Gong, Giuseppe La Regina, Jiulin Chen, Fangfang Dou, Romano Silvestri, Chuan Chen, Zhihua Yu
Int. J. Biol. Sci. 2021; 17(13): 3305-3319. doi:10.7150/ijbs.63329
[Abstract] [Full text] [PDF]


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Research Paper
The role of N-cadherin/c-Jun/NDRG1 axis in the progression of prostate cancer
Yongjun Quan, Xiaodong Zhang, William Butler, Zhen Du, Mingdong Wang, Yuexin Liu, Hao Ping
Int. J. Biol. Sci. 2021; 17(13): 3288-3304. doi:10.7150/ijbs.63300
[Abstract] [Full text] [PDF]


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Review
CD47/SIRPα pathway mediates cancer immune escape and immunotherapy
Xiao Jia, Bingjun Yan, Xiaoqing Tian, Qian Liu, Jianhua Jin, Juanjuan Shi, Yongzhong Hou
Int. J. Biol. Sci. 2021; 17(13): 3281-3287. doi:10.7150/ijbs.60782
[Abstract] [Full text] [PDF]


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Review
Emerging Roles of LncRNAs in the EZH2-regulated Oncogenic Network
Aixin Hao, Yunxuan Wang, Daniel B. Stovall, Yu Wang, Guangchao Sui
Int. J. Biol. Sci. 2021; 17(13): 3268-3280. doi:10.7150/ijbs.63488
[Abstract] [Full text] [PDF]


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Research Paper
Discovery and Validation of Nitroxoline as a Novel STAT3 Inhibitor in Drug-resistant Urothelial Bladder Cancer
Wenfeng Lin, Jingkai Sun, Takuya Sadahira, Naijin Xu, Koichiro Wada, Chunxiao Liu, Motoo Araki, Abai Xu, Masami Watanabe, Yasutomo Nasu, Peng Huang
Int. J. Biol. Sci. 2021; 17(12): 3255-3267. doi:10.7150/ijbs.63125
[Abstract] [Full text] [PDF]


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Research Paper
BRCA1 Antibodies Matter
Jing Yang, Leilei Qi, Huai-Chin Chiang, Bin Yuan, Rong Li, Yanfen Hu
Int. J. Biol. Sci. 2021; 17(12): 3239-3254. doi:10.7150/ijbs.63115
[Abstract] [Full text] [PDF]


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Research Paper
BC-N102 suppress breast cancer tumorigenesis by interfering with cell cycle regulatory proteins and hormonal signaling, and induction of time-course arrest of cell cycle at G1/G0 phase
Bashir Lawal, Yu-Cheng Kuo, Alexander T. H. Wu, Hsu-Shan Huang
Int. J. Biol. Sci. 2021; 17(12): 3224-3238. doi:10.7150/ijbs.62808
[Abstract] [Full text] [PDF]


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Research Paper
Rapamycin and trametinib: a rational combination for treatment of NSCLC
Chao-Yue Sun, Yi-Zhuo Li, Di Cao, Yu-Feng Zhou, Mei-Yin Zhang, Hui-Yun Wang
Int. J. Biol. Sci. 2021; 17(12): 3211-3223. doi:10.7150/ijbs.62752
[Abstract] [Full text] [PDF]


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Review
LncRNA H19: A novel oncogene in multiple cancers
Jun Yang, Manlong Qi, Xiang Fei, Xia Wang, Kefeng Wang
Int. J. Biol. Sci. 2021; 17(12): 3188-3208. doi:10.7150/ijbs.62573
[Abstract] [Full text] [PDF]


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Research Paper
Berberine modulates deacetylation of PPARγ to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway
Yingxi Xu, Tianhao Yu, Guojing Ma, Lixia Zheng, Xuehan Jiang, Fan Yang, Zhuo Wang, Na Li, Zheng He, Xiaoyu Song, Deliang Wen, Juan Kong, Yang Yu, Liu Cao
Int. J. Biol. Sci. 2021; 17(12): 3173-3187. doi:10.7150/ijbs.62556
[Abstract] [Full text] [PDF]


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Research Paper
DDX39 as a predictor of clinical prognosis and immune checkpoint therapy efficacy in patients with clear cell renal cell carcinoma
Yewei Bao, Aimin Jiang, Kai Dong, Xinxin Gan, Wenliang Gong, Zhenjie Wu, Bing Liu, Yi Bao, Jie Wang, Linhui Wang
Int. J. Biol. Sci. 2021; 17(12): 3158-3172. doi:10.7150/ijbs.62553
[Abstract] [Full text] [PDF]

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

new Latest impact factor 6.58. Congratulations!

new🆘The continued global battle against SARS-CoV-2 and COVID-19: Special issue on Coronavirus disease https://www.ijbs.com/v17i6

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Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Research Paper
Analysis of Genome Sequences of Coagulase-Negative Staphylococci Isolates from South Africa and Nigeria Highlighted Environmentally Driven Heterogeneity
Tawanda Elias Maguvu, Adegboyega Oyedele Oladipo, Cornelius Carlos Bezuidenhout
J. Genomics 2021; 9: 26-37. doi:10.7150/jgen.53019
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Draft genome sequences of three filamentous cyanobacteria isolated from brackish habitats
Joanne Sarah Boden, Michele Grego, Henk Bolhuis, Patricia Sánchez-Baracaldo
J. Genomics 2021; 9: 20-25. doi:10.7150/jgen.53678
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Review
The Genetic Background of Central Serous Chorioretinopathy: A Review on Central Serous Chorioretinopathy Genes
Konstantinos Giannopoulos, Maria Gazouli, Klio Chatzistefanou, Anthi Bakouli, Marilita M Moschos
J. Genomics 2021; 9: 10-19. doi:10.7150/jgen.55545
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Draft Genome Sequence of Enterobacter sp. AS-1, a Potential Eurytrophic Recombination Host
Yuki Iwasaki, Yuya Itoiri, Sota Ihara, Hironaga Akita, Mamoru Oshiki, Zen-ichiro Kimura
J. Genomics 2021; 9: 6-9. doi:10.7150/jgen.53040
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details