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Research Paper
Evaluation and characterization of HSPA5 (GRP78) expression profiles in normal individuals and cancer patients with COVID-19
Jiewen Fu, Chunli Wei, Jiayue He, Lianmei Zhang, Ju Zhou, Kyathegowdanadoddi Srinivasa Balaji, Shiyi Shen, Jiangzhou Peng, Amrish Sharma, Junjiang Fu
Int. J. Biol. Sci. 2021; 17(3): 897-910. doi:10.7150/ijbs.54055
[Abstract] [Full text] [PDF]


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Research Paper
Novel biomarkers for post-contrast acute kidney injury identified from long non-coding RNA expression profiles
Guanzhong Chen, Bowen Liu, Shiqun Chen, Huanqiang Li, Jin Liu, Ziling Mai, Enzhao Chen, Chunyun Zhou, Guoli Sun, Zhaodong Guo, Li Lei, Shanyi Huang, Liyao Zhang, Min Li, Ning Tan, Hong Li, Yulin Liao, Jia Liu, Jiyan Chen, Yong Liu
Int. J. Biol. Sci. 2021; 17(3): 882-896. doi:10.7150/ijbs.45294
[Abstract] [Full text] [PDF]


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Research Paper
MLKL inhibits intestinal tumorigenesis by suppressing STAT3 signaling pathway
Qun Zhao, Xinran Cheng, Jian Guo, Yun Bi, Li Kuang, Jianhua Ren, Jing Zhong, Longrui Pan, Xudong Zhang, Yang Guo, Yongqiang Liu, Shu Jin, Yan Tan, Xianjun Yu
Int. J. Biol. Sci. 2021; 17(3): 869-881. doi:10.7150/ijbs.56152
[Abstract] [Full text] [PDF]


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Research Paper
PTEN-mediated AKT/β-catenin signaling enhances the proliferation and expansion of Lgr5+ hepatocytes
Jimin Han, Kaijun Lin, Xuezheng Zhang, Lingchen Yan, Yu Chen, Haiyan Chen, Jianjun Liu, Jia Liu, Yaojiong Wu
Int. J. Biol. Sci. 2021; 17(3): 861-868. doi:10.7150/ijbs.56091
[Abstract] [Full text] [PDF]


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Research Paper
CD151 promotes Colorectal Cancer progression by a crosstalk involving CEACAM6, LGR5 and Wnt signaling via TGFβ1
Tao Yang, Huibing Wang, Meng Li, Linqi Yang, Yu Han, Chao Liu, Baowen Zhang, Mingfa Wu, Gang Wang, Zhenya Zhang, Wenqi Zhang, Jianming Huang, Huaxing Zhang, Ting Cao, Pingping Chen, Wei Zhang
Int. J. Biol. Sci. 2021; 17(3): 848-860. doi:10.7150/ijbs.53657
[Abstract] [Full text] [PDF]


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Research Paper
Anterior gradient 2 increases long-chain fatty acid uptake via stabilizing FABP1 and facilitates lipid accumulation
Yunqiu Wang, Mengqi Jia, Chuanjie Liang, Nan Sheng, Xiaodan Wang, Fang Wang, Yanhai Luo, Jin Jiang, Liangyu Cai, Huanmin Niu, Deyu Zhu, Effat Un Nesa, Charles YF Young, Huiqing Yuan
Int. J. Biol. Sci. 2021; 17(3): 834-847. doi:10.7150/ijbs.57099
[Abstract] [Full text] [PDF]


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Review
Understanding the Effects of Gut Microbiota Dysbiosis on Nonalcoholic Fatty Liver Disease and the Possible Probiotics Role: Recent Updates
Ashiq Khan, Zitong Ding, Muhammad Ishaq, Ali Sher Bacha, Israr Khan, Anum Hanif, Wenyuan Li, Xusheng Guo
Int. J. Biol. Sci. 2021; 17(3): 818-833. doi:10.7150/ijbs.56214
[Abstract] [Full text] [PDF]


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Review
Crucial roles of different RNA-binding hnRNP proteins in Stem Cells
Wen Xie, Hecheng Zhu, Ming Zhao, Lei Wang, Shasha Li, Cong Zhao, Yao Zhou, Bin Zhu, Xingjun Jiang, Weidong Liu, Caiping Ren
Int. J. Biol. Sci. 2021; 17(3): 807-817. doi:10.7150/ijbs.55120
[Abstract] [Full text] [PDF]


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Research Paper
LncRNA-NONHSAT024778 promote the proliferation and invasion of chordoma cell by regulating miR-1290/Robo1 axis
Bin Wang, Kai Zhang, Sen Meng, Xiaofeng Shao, Zhangzhe Zhou, Haiqing Mao, Ziqiang Zhu, Hao Chen, Huilin Yang, Kangwu Chen
Int. J. Biol. Sci. 2021; 17(3): 796-806. doi:10.7150/ijbs.54091
[Abstract] [Full text] [PDF]


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Research Paper
miR-26b enhances the sensitivity of hepatocellular carcinoma to Doxorubicin via USP9X-dependent degradation of p53 and regulation of autophagy
Enjiang Chen, Enliang Li, Hao Liu, Yue Zhou, Liang Wen, Jianxin Wang, Yi Wang, Longyun Ye, Tingbo Liang
Int. J. Biol. Sci. 2021; 17(3): 781-795. doi:10.7150/ijbs.52517
[Abstract] [Full text] [PDF]


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Research Paper
Linc-KILH potentiates Notch1 signaling through inhibiting KRT19 phosphorylation and promotes the malignancy of hepatocellular carcinoma
Xudong Zhang, Xiaoliang Xu, Zechuan Zhang, Cailin Xue, Zhijun Kong, Siyuan Wu, Xiao Yun, Yue Fu, Chunfu Zhu, Xihu Qin
Int. J. Biol. Sci. 2021; 17(3): 768-780. doi:10.7150/ijbs.52279
[Abstract] [Full text] [PDF]


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Research Paper
AKR1B10 confers resistance to radiotherapy via FFA/TLR4/NF-κB axis in nasopharyngeal carcinoma
Xiangting Liu, Zheng Hu, Jiayao Qu, Jia Li, Ke Gong, Li Wang, Jing Jiang, Xiangning Li, Rongzhang He, Lili Duan, Weihao Luo, Chenglai Xia, Dixian Luo
Int. J. Biol. Sci. 2021; 17(3): 756-767. doi:10.7150/ijbs.52927
[Abstract] [Full text] [PDF]


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Research Paper
Bovine serum albumin aggravates macrophage M1 activation and kidney injury in heterozygous Klotho-deficient mice via the gut microbiota-immune axis
Lingyun Lai, Yi Li, Jianjun Liu, Lei Luo, Jianguo Tang, Jun Xue, Te Liu
Int. J. Biol. Sci. 2021; 17(3): 742-755. doi:10.7150/ijbs.56424
[Abstract] [Full text] [PDF]


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Research Paper
The G1 phase optical reporter serves as a sensor of CDK4/6 inhibition in vivo
Cuiping Guo, Yuxian Guo, Jingjing Liu, Yiyang Gao, Min Wei, Ruijun Zhao, Min Chen, Guojun Zhang
Int. J. Biol. Sci. 2021; 17(3): 728-741. doi:10.7150/ijbs.52101
[Abstract] [Full text] [PDF]


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Review
Tight junctions and their regulation by non-coding RNAs
Xiaojiao Zhao, Hongliang Zeng, Li Lei, Xiaoliang Tong, Lun Yang, Yan Yang, Si Li, Ying Zhou, Liping Luo, Jinhua Huang, Rong Xiao, Jing Chen, Qinghai Zeng
Int. J. Biol. Sci. 2021; 17(3): 712-727. doi:10.7150/ijbs.45885
[Abstract] [Full text] [PDF]


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Research Paper
Ferroptosis-Related Long Non-Coding RNA signature predicts the prognosis of Head and neck squamous cell carcinoma
Yun Tang, Cheng Li, You-Jing Zhang, Zeng-Hong Wu
Int. J. Biol. Sci. 2021; 17(3): 702-711. doi:10.7150/ijbs.55552
[Abstract] [Full text] [PDF]

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau
Editor-in-Chief's Profile

new Latest impact factor 4.858 according to 2020 release of JCR®.

🆘 The global battle against SARS-CoV-2 and COVID-19: Special issue on Coronavirus disease https://www.ijbs.com/v16i10
Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Research Paper
Draft genome sequences of three filamentous cyanobacteria isolated from brackish habitats
Joanne Sarah Boden, Michele Grego, Henk Bolhuis, Patricia Sánchez-Baracaldo
J. Genomics 2021; 9: 20-25. doi:10.7150/jgen.53678
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Review
The Genetic Background of Central Serous Chorioretinopathy: A Review on Central Serous Chorioretinopathy Genes
Konstantinos Giannopoulos, Maria Gazouli, Klio Chatzistefanou, Anthi Bakouli, Marilita M Moschos
J. Genomics 2021; 9: 10-19. doi:10.7150/jgen.55545
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Draft Genome Sequence of Enterobacter sp. AS-1, a Potential Eurytrophic Recombination Host
Yuki Iwasaki, Yuya Itoiri, Sota Ihara, Hironaga Akita, Mamoru Oshiki, Zen-ichiro Kimura
J. Genomics 2021; 9: 6-9. doi:10.7150/jgen.53040
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Isolation, draft genome sequencing and identification of Enterobacter roggenkampii CCI9
Hironaga Akita, Yuya Itoiri, Noriyo Takeda, Zen-ichiro Kimura, Hiroyuki Inoue, Akinori Matsushika
J. Genomics 2021; 9: 1-5. doi:10.7150/jgen.46294
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details