toc.jpg

Research Paper
Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1G93A Mice
Qi Zhou, Lei Zhu, Weiwen Qiu, Yue Liu, Fang Yang, Wenzhi Chen, Renshi Xu
Int. J. Biol. Sci. 2020; 16(2): 284-297. doi:10.7150/ijbs.38487
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
TIPE regulates VEGFR2 expression and promotes angiogenesis in colorectal cancer
Mengya Zhong, Nini Li, Xingfeng Qiu, Yuhan Ye, Huiyu Chen, Jianyu Hua, Ping Yin, Guohong Zhuang
Int. J. Biol. Sci. 2020; 16(2): 272-283. doi:10.7150/ijbs.37906
[Abstract] [Full text] [PDF]


toc.jpg

Review
Hydrogen Sulfide Plays an Important Protective Role through Influencing Endoplasmic Reticulum Stress in Diseases
Honggang Wang, Xingzhuo Shi, Mengyuan Qiu, Shuangyu Lv, Huiyang Liu
Int. J. Biol. Sci. 2020; 16(2): 264-271. doi:10.7150/ijbs.38143
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
LRRC75A antisense lncRNA1 knockout attenuates inflammatory responses of bovine mammary epithelial cells
Xixi Wang, Hao Wang, Ruiqi Zhang, Dan Li, Ming-Qing Gao
Int. J. Biol. Sci. 2020; 16(2): 251-263. doi:10.7150/ijbs.38214
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Bovid microRNAs involved in the process of spermatogonia differentiation into spermatocytes
Chuanfei Xu, Mujahid ali Shah, TserangDonko Mipam, Shixin Wu, Chuanping Yi, Hui Luo, Meng Yuan, Zhixin Chai, Wangsheng Zhao, Xin Cai
Int. J. Biol. Sci. 2020; 16(2): 239-250. doi:10.7150/ijbs.38232
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Silencing of brain-expressed X-linked 2 (BEX2) promotes colorectal cancer metastasis through the Hedgehog signaling pathway
Yinuo Tan, Yeting Hu, Qian Xiao, Yang Tang, Haiyan Chen, Jinjie He, Liubo Chen, Kai Jiang, Zhanhuai Wang, Ying Yuan, Kefeng Ding
Int. J. Biol. Sci. 2020; 16(2): 228-238. doi:10.7150/ijbs.38431
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Soluble CD83 alleviates experimental allergic rhinitis through modulating antigen-specific Th2 cell property
Yong-Jin Wu, Yan-Nan Song, Xiao-Rui Geng, Fei Ma, Li-Hua Mo, Xiao-Wen Zhang, Da-Bo Liu, Zhi-Gang Liu, Ping-Chang Yang
Int. J. Biol. Sci. 2020; 16(2): 216-227. doi:10.7150/ijbs.38722
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Transforming growth factor beta (TGF-β) is activated by the CtBP2-p300-AP1 transcriptional complex in chronic renal failure
Ping Zhou, Xiaoxiao Wan, Yan Zou, Zhi Chen, Aimin Zhong
Int. J. Biol. Sci. 2020; 16(2): 204-215. doi:10.7150/ijbs.38841
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Ruxolitinib Alleviates Renal Interstitial Fibrosis in UUO Mice
Yu Bai, Wei Wang, Ping Yin, Jian Gao, Lei Na, Yu Sun, Zhuo Wang, Zhongbo Zhang, Chenghai Zhao
Int. J. Biol. Sci. 2020; 16(2): 194-203. doi:10.7150/ijbs.39024
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
GATA Binding Protein 4 Regulates Tooth Root Dentin Development via FBP1
Yuxin Zhang, Mengru Fang, Zhiwen Yang, Wenhao Qin, Shuyu Guo, Junqing Ma, Wenjing Chen
Int. J. Biol. Sci. 2020; 16(1): 181-193. doi:10.7150/ijbs.36567
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Legumain Promotes Gastric Cancer Progression Through Tumor-associated Macrophages In vitro and In vivo
Hongbin Wang, Binghong Chen, Yingying Lin, Yi Zhou, Xiaobo Li
Int. J. Biol. Sci. 2020; 16(1): 172-180. doi:10.7150/ijbs.36467
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
A Long Non-coding RNA Lnc712 Regulates Breast Cancer Cell Proliferation
Yue Cui, Chunxiao Lu, Zhiming Zhang, Aiqin Mao, Lei Feng, Li Fu, Feng Gu, Xin Ma, Dongxu He
Int. J. Biol. Sci. 2020; 16(1): 162-171. doi:10.7150/ijbs.36429
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis
Nan Zhang, Fu Peng, Yujia Wang, Li Yang, Fengbo Wu, Xiaoyun Wang, Cui Ye, Bo Han, Gu He
Int. J. Biol. Sci. 2020; 16(1): 147-161. doi:10.7150/ijbs.36955
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Gut microbiome associated with APC gene mutation in patients with intestinal adenomatous polyps
Siyuan Liang, Yan Mao, Ming Liao, Yansong Xu, Yingchun Chen, Xiaoliang Huang, Chuangyi Wei, Changtao Wu, Qiuyan Wang, Xiaoyan Pan, Weizhong Tang
Int. J. Biol. Sci. 2020; 16(1): 135-146. doi:10.7150/ijbs.37399
[Abstract] [Full text] [PDF]


toc.jpg

Review
Current Status of Therapeutic Approaches against Peripheral Nerve Injuries: A Detailed Story from Injury to Recovery
Ghulam Hussain, Jing Wang, Azhar Rasul, Haseeb Anwar, Muhammad Qasim, Shamaila Zafar, Nimra Aziz, Aroona Razzaq, Rashad Hussain, Jose-Luis Gonzalez de Aguilar, Tao Sun
Int. J. Biol. Sci. 2020; 16(1): 116-134. doi:10.7150/ijbs.35653
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Long non-coding RNA steroid receptor activator promotes the progression of endometrial cancer via Wnt/ β-catenin signaling pathway
Sun-Ae Park, Lee Kyung Kim, Young Tae Kim, Tae-Hwe Heo, Hee Jung Kim
Int. J. Biol. Sci. 2020; 16(1): 99-115. doi:10.7150/ijbs.35643
[Abstract] [Full text] [PDF]

Cover image
Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

Impact factor is 4.067 according to 2019 release of Journal Citation Reports®.
new Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Research Paper
Genomic characterization of a pectinolytic isolate of Serratia oryzae isolated from lake water
Nicole Hugouvieux-Cotte-Pattat, Cécile Jacot-des-Combes, Jérôme Briolay
J. Genomics 2019; 7: 64-72. doi:10.7150/jgen.38365
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Short Research Paper
Whole Genome Sequence of Marinobacter salarius Strain SMR5, Shown to Promote Growth in its Diatom Host
Mats Töpel, Matthew I.M. Pinder, Oskar N. Johansson, Olga Kourtchenko, Anna Godhe, Adrian K. Clarke
J. Genomics 2019; 7: 60-63. doi:10.7150/jgen.39039
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
The Draft Genome of a Hydrogen-producing Cyanobacterium, Arthrospira platensis NIES-46
Shigekatsu Suzuki, Haruyo Yamaguchi, Masanobu Kawachi
J. Genomics 2019; 7: 56-59. doi:10.7150/jgen.38149
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Short Research Paper
Draft genome sequences for three unisolated Alnus-infective Frankia Sp+ strains, AgTrS, AiOr and AvVan, the first sequenced Frankia strains able to sporulate in-planta
Lorine Bethencourt, Florian Vautrin, Najwa Taib, Audrey Dubost, Lucia Castro-Garcia, Olivier Imbaud, Danis Abrouk, Pascale Fournier, Jérôme Briolay, Agnès Nguyen, Philippe Normand, Maria P. Fernandez, Céline Brochier-Armanet, Aude Herrera-Belaroussi
J. Genomics 2019; 7: 50-55. doi:10.7150/jgen.35875
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details