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Research Paper
ALDH 2 conferred neuroprotection on cerebral ischemic injury by alleviating mitochondria-related apoptosis through JNK/caspase-3 signing pathway
Pingping Xia, Fan Zhang, Yajing Yuan, Cheng Chen, Yan Huang, Longyan Li, E Wang, Qulian Guo, Zhi Ye
Int. J. Biol. Sci. 2020; 16(8): 1303-1323. doi:10.7150/ijbs.38962
[Abstract] [Full text] [PDF]


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Research Paper
Selective targeting of the TLR4 co-receptor, MD2, prevents colon cancer growth and lung metastasis
Vinothkumar Rajamanickam, Tao Yan, Shanmei Xu, Junguo Hui, Xiaohong Xu, Luqing Ren, Zhoudi Liu, Guang Liang, Ouchen Wang, Yi Wang
Int. J. Biol. Sci. 2020; 16(8): 1288-1302. doi:10.7150/ijbs.39098
[Abstract] [Full text] [PDF]


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Research Paper
Superparamagnetic iron oxide nanoparticles drive miR-485-5p inhibition in glioma stem cells by silencing Tie1 expression
Zhiguang Pan, Yongyi Huang, Haiyang Qian, Xiling Du, Wenxing Qin, Te Liu
Int. J. Biol. Sci. 2020; 16(7): 1274-1287. doi:10.7150/ijbs.42887
[Abstract] [Full text] [PDF]


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Research Paper
SASH1 promotes melanin synthesis and migration via suppression of TGF-β1 secretion in melanocytes resulting in pathologic hyperpigmentation
Hong Zhou Cui, Shu Ping Guo, Hong Xia He, Hui Na Guo, Yu Liang Zhang, Bin Quan Wang
Int. J. Biol. Sci. 2020; 16(7): 1264-1273. doi:10.7150/ijbs.38415
[Abstract] [Full text] [PDF]


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Research Paper
EHMT2/G9a Inhibits Aortic Smooth Muscle Cell Death by Suppressing Autophagy Activation
Tai-Qiang Chen, Nan Hu, Bo Huo, Jackson Ferdinand Masau, Xin Yi, Xiao-Xuan Zhong, Yong-Jie Chen, Xian Guo, Xue-Hai Zhu, Xiang Wei, Ding-Sheng Jiang
Int. J. Biol. Sci. 2020; 16(7): 1252-1263. doi:10.7150/ijbs.38835
[Abstract] [Full text] [PDF]


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Research Paper
Axl-148b chimeric aptamers inhibit breast cancer and melanoma progression
Lorena Quirico, Francesca Orso, Carla L. Esposito, Sofia Bertone, Roberto Coppo, Laura Conti, Silvia Catuogno, Federica Cavallo, Vittorio de Franciscis, Daniela Taverna
Int. J. Biol. Sci. 2020; 16(7): 1238-1251. doi:10.7150/ijbs.39768
[Abstract] [Full text] [PDF]


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Research Paper
Development and validation of a novel nomogram to predict overall survival in gastric cancer with lymph node metastasis
Minjie Mao, Ao Zhang, Yi He, Lin Zhang, Wen Liu, Yiling Song, Shuqi Chen, Guanmin Jiang, Xueping Wang
Int. J. Biol. Sci. 2020; 16(7): 1230-1237. doi:10.7150/ijbs.39161
[Abstract] [Full text] [PDF]


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Research Paper
MiR-139-5p negatively regulates PMP22 to repress cell proliferation by targeting the NF-κB signaling pathway in gastric cancer
Jingjing Hou, Huiqin Zhuo, Xin Chen, Jia Cheng, Wei Zheng, Mengya Zhong, Jianchun Cai
Int. J. Biol. Sci. 2020; 16(7): 1218-1229. doi:10.7150/ijbs.40338
[Abstract] [Full text] [PDF]


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Research Paper
Therapeutic Targeting of CDK7 Suppresses Tumor Progression in Intrahepatic Cholangiocarcinoma
Hua-Dong Chen, Chen-Song Huang, Qiong-Cong Xu, Fuxi Li, Xi-Tai Huang, Jie-Qin Wang, Shi-Jin Li, Wei Zhao, Xiao-Yu Yin
Int. J. Biol. Sci. 2020; 16(7): 1207-1217. doi:10.7150/ijbs.39779
[Abstract] [Full text] [PDF]


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Review
LncRNAs regulate metabolism in cancer
Wenyu Lin, Qiyin Zhou, Chao-Qun Wang, Liyuan Zhu, Chao Bi, Shuzhen Zhang, Xian Wang, Hongchuan Jin
Int. J. Biol. Sci. 2020; 16(7): 1194-1206. doi:10.7150/ijbs.40769
[Abstract] [Full text] [PDF]


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Research Paper
TAF1L promotes development of oral squamous cell carcinoma via decreasing autophagy-dependent apoptosis
Daiwei Wang, Hong Qi, Haoxing Zhang, Wei Zhou, Yanpeng Li, Ang Li, Qiong Liu, Yun Wang
Int. J. Biol. Sci. 2020; 16(7): 1180-1193. doi:10.7150/ijbs.41148
[Abstract] [Full text] [PDF]


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Research Paper
Potential Crosstalk between Liver and Extra-liver Organs in Mouse Models of Acute Liver Injury
Yufan Zheng, Baiping Cui, Wenrui Sun, Sining Wang, Xu Huang, Han Gao, Fei Gao, Qian Cheng, Limin Lu, Yanpeng An, Xiaobo Li, Ning Sun
Int. J. Biol. Sci. 2020; 16(7): 1166-1179. doi:10.7150/ijbs.41293
[Abstract] [Full text] [PDF]


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Research Paper
Development and Validation of a Prognostic Nomogram for Gastric Cancer Based on DNA Methylation-Driven Differentially Expressed Genes
Yi Bai, Chunlian Wei, Yuxin Zhong, Yamin Zhang, Junyu Long, Shan Huang, Fucun Xie, Yantao Tian, Xi Wang, Haitao Zhao
Int. J. Biol. Sci. 2020; 16(7): 1153-1165. doi:10.7150/ijbs.41587
[Abstract] [Full text] [PDF]


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Research Paper
Parkinson's Disease: A Comprehensive Analysis of Fungi and Bacteria in Brain Tissue
Diana Pisa, Ruth Alonso, Luis Carrasco
Int. J. Biol. Sci. 2020; 16(7): 1135-1152. doi:10.7150/ijbs.42257
[Abstract] [Full text] [PDF]


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Research Paper
Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways
Xinxing Lu, Feiya Yang, Dexi Chen, Qinxin Zhao, Dong Chen, Hao Ping, Nianzeng Xing
Int. J. Biol. Sci. 2020; 16(7): 1121-1134. doi:10.7150/ijbs.41686
[Abstract] [Full text] [PDF]


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Research Paper
C-terminal binding proteins 1 and 2 in traumatic brain injury-induced inflammation and their inhibition as an approach for anti-inflammatory treatment
Hong Li, Caiguo Zhang, Chunxia Yang, Melanie Blevins, David Norris, Rui Zhao, Mingxia Huang
Int. J. Biol. Sci. 2020; 16(7): 1107-1120. doi:10.7150/ijbs.42109
[Abstract] [Full text] [PDF]

Cover image
Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

Impact factor is 4.067 according to 2019 release of Journal Citation Reports®.
Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Research Paper
Programmable CRISPR interference for gene silencing using Cas13a in mosquitoes
Aditi Kulkarni, Wanqin Yu, Alex Moon, Ashmita Pandey, Kathryn A. Hanley, Jiannong Xu
J. Genomics 2020; 8: 30-36. doi:10.7150/jgen.43928
[Abstract] [Full text] [PDF]


Research Paper
Draft Genome Analysis of Christensenella minuta DSM 22607, exhibiting an unusual expansion of transporter homologs of unknown function
David A Coil, Guillaume Jospin, Jonathan A. Eisen
J. Genomics 2020; 8: 25-29. doi:10.7150/jgen.43162
[Abstract] [Full text] [PDF]


Short Research Paper
Draft genome sequence of Deinococcus sp. KR-1, a potential strain for palladium-leaching
Hironaga Akita, Yuya Itoiri, Akio Kumagai, Noriyo Takeda, Akinori Matsushika, Mamoru Oshiki, Zen-ichiro Kimura
J. Genomics 2020; 8: 21-24. doi:10.7150/jgen.42020
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Isolation and genomic analysis of 11-aminoundecanoic acid-degrading bacterium Pseudomonas sp. JG-B from nylon 11 enrichment culture
Jocelyn Gatz-Schrupp, Peter Deckard, Benjamin Hufford, Steven Ly, Peter Tupa, Hisako Masuda
J. Genomics 2020; 8: 16-20. doi:10.7150/jgen.42095
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details