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Research Paper
Specific Pyruvate Kinase M2 Inhibitor, Compound 3K, Induces Autophagic Cell Death through Disruption of the Glycolysis Pathway in Ovarian Cancer Cells
Jae Hyeon Park, Amit Kundu, Su Hyun Lee, ChunXue Jiang, Song Hee Lee, Ye Seul Kim, So Young Kyung, So Hyun Park, Hyung Sik Kim
Int. J. Biol. Sci. 2021; 17(8): 1895-1908. doi:10.7150/ijbs.59855
[Abstract] [Full text] [PDF]


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Research Paper
Protopanaxadiol improves endometriosis associated infertility and miscarriage in sex hormones receptors-dependent and independent manners
Zhen-Zhen Lai, Hui-Li Yang, Jia-Wei Shi, Hui-Hui Shen, Yan Wang, Kai-Kai Chang, Tao Zhang, Jiang-Feng Ye, Jian-Song Sun, Xue-Min Qiu, Ming-Qing Li
Int. J. Biol. Sci. 2021; 17(8): 1878-1894. doi:10.7150/ijbs.58657
[Abstract] [Full text] [PDF]


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Research Paper
Could protein content of Urinary Extracellular Vesicles be useful to detect Cirrhosis in Alcoholic Liver Disease?
Esperanza Gonzalez, Mikel Azkargorta, Clara Garcia-Vallicrosa, Janire Prieto-Elordui, Felix Elortza, Sonia Blanco-Sampascual, Juan Manuel Falcon-Perez
Int. J. Biol. Sci. 2021; 17(8): 1864-1877. doi:10.7150/ijbs.59725
[Abstract] [Full text] [PDF]


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Review
MicroRNAs in the Pathogenesis of Nonalcoholic Fatty Liver Disease
Zhiqiang Fang, Guorui Dou, Lin Wang
Int. J. Biol. Sci. 2021; 17(7): 1851-1863. doi:10.7150/ijbs.59588
[Abstract] [Full text] [PDF]


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Research Paper
Macrophage migration inhibitory factor regulates joint capsule fibrosis by promoting TGF-β1 production in fibroblasts
Yuxin Zhang, Zhonglong Liu, Kexin Wang, Shenji Lu, Shuai Fan, Lili Xu, Bin Cai
Int. J. Biol. Sci. 2021; 17(7): 1837-1850. doi:10.7150/ijbs.57025
[Abstract] [Full text] [PDF]


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Research Paper
Accelerated Bone Regeneration by Astragaloside IV through Stimulating the Coupling of Osteogenesis and Angiogenesis
Feng Wang, Huijuan Qian, Lingchi Kong, Wenbo Wang, Xiaoyu Wang, Ze Xu, Yimin Chai, Jia Xu, Qinglin Kang
Int. J. Biol. Sci. 2021; 17(7): 1821-1836. doi:10.7150/ijbs.57681
[Abstract] [Full text] [PDF]


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Research Paper
ARHGAP25 Inhibits Pancreatic Adenocarcinoma Growth by Suppressing Glycolysis via AKT/mTOR Pathway
Wen-Kuan Huang, Yi Chen, Huafang Su, Tung-Ying Chen, Jiwei Gao, Yaxuan Liu, Chun-Nan Yeh, Shuijie Li
Int. J. Biol. Sci. 2021; 17(7): 1808-1820. doi:10.7150/ijbs.55919
[Abstract] [Full text] [PDF]


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Research Paper
MicroRNA-370 carried by M2 macrophage-derived exosomes alleviates asthma progression through inhibiting the FGF1/MAPK/STAT1 axis
Chunlu Li, Chengsi Deng, Tingting Zhou, Jiapeng Hu, Bing Dai, Fei Yi, Na Tian, Lijun Jiang, Xiang Dong, Qingfeng Zhu, Siyi Zhang, Hongyan Cui, Liu Cao, Yunxiao Shang
Int. J. Biol. Sci. 2021; 17(7): 1795-1807. doi:10.7150/ijbs.59715
[Abstract] [Full text] [PDF]


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Research Paper
Aldolase A Enhances Intrahepatic Cholangiocarcinoma Proliferation and Invasion through Promoting Glycolysis
Xiang Li, Chang Yu, Yichun Luo, Jiacheng Lin, Fang Wang, Xuehua Sun, Yueqiu Gao, Weifeng Tan, Qiang Xia, Xiaoni Kong
Int. J. Biol. Sci. 2021; 17(7): 1782-1794. doi:10.7150/ijbs.59068
[Abstract] [Full text] [PDF]


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Research Paper
Biological and Physiochemical Methods of Biofilm Adhesion Resistance Control of Medical-Context Surface
Yuanzhe Li, Xiang Li, Yu Hao, Yang Liu, ZhiLi Dong, Kexin Li
Int. J. Biol. Sci. 2021; 17(7): 1769-1781. doi:10.7150/ijbs.59025
[Abstract] [Full text] [PDF]


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Research Paper
Long Noncoding RNA KCNQ1OT1 is a Prognostic Biomarker and mediates CD8+ T cell exhaustion by regulating CD155 Expression in Colorectal Cancer
Zheng-bin Lin, Pei Long, Zhan Zhao, Yi-ran Zhang, Xiao-dong Chu, Xiao-xu Zhao, Hui Ding, Song-wei Huan, Yun-long Pan, Jing-hua Pan
Int. J. Biol. Sci. 2021; 17(7): 1757-1768. doi:10.7150/ijbs.59001
[Abstract] [Full text] [PDF]


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Research Paper
LRP1B mutation is associated with tumor HPV status and promotes poor disease outcomes with a higher mutation count in HPV-related cervical carcinoma and head & neck squamous cell carcinoma
Can-hui Cao, Rang Liu, Xin-ran Lin, Jia-qi Luo, Li-juan Cao, Qiu-ju Zhang, Shou-ren Lin, Lan Geng, Zhong-yi Sun, Si-kang Ye, Zhi-ying Yu, Yu Shi, Xi Xia
Int. J. Biol. Sci. 2021; 17(7): 1744-1756. doi:10.7150/ijbs.56970
[Abstract] [Full text] [PDF]


Erratum
Long noncoding RNA LINC01123 promotes the proliferation and invasion of hepatocellular carcinoma cells by modulating the miR-34a-5p/TUFT1 axis: Erratum
Zunqiang Xiao, Yang Liu, Junjun Zhao, Lijie Li, Linjun Hu, Qiliang Lu, Zhi Zeng, Xin Liu, Dongsheng Huang, Wei Yang, Qiuran Xu
Int. J. Biol. Sci. 2021; 17(7): 1742-1743. doi:10.7150/ijbs.61130
[Abstract] [Full text] [PDF]


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Review
The emerging function and clinical significance of circRNAs in Thyroid Cancer and Autoimmune Thyroid Diseases
Yu Zhang, Dong-Dong Jia, Yi-Fei Zhang, Meng-Die Cheng, Wen-Xiu Zhu, Pei-Feng Li, Yin-Feng Zhang
Int. J. Biol. Sci. 2021; 17(7): 1731-1741. doi:10.7150/ijbs.55381
[Abstract] [Full text] [PDF]


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Research Paper
NDRG1 regulates Filopodia-induced Colorectal Cancer invasiveness via modulating CDC42 activity
Batuer Aikemu, Yanfei Shao, Guang Yang, Junjun Ma, Sen Zhang, Xiao Yang, Hiju Hong, Galiya Yesseyeva, Ling Huang, Hongtao Jia, Chenxing Wang, Lu Zang, Jing Sun, Minhua Zheng
Int. J. Biol. Sci. 2021; 17(7): 1716-1730. doi:10.7150/ijbs.56694
[Abstract] [Full text] [PDF]


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Review
Splicing factor SRSF2-centric gene regulation
Kun Li, Ziqiang Wang
Int. J. Biol. Sci. 2021; 17(7): 1708-1715. doi:10.7150/ijbs.58888
[Abstract] [Full text] [PDF]

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

new Latest impact factor 4.858 according to 2020 release of JCR®.

new🆘The continued global battle against SARS-CoV-2 and COVID-19: Special issue on Coronavirus disease https://www.ijbs.com/v17i6

🆘 The global battle against SARS-CoV-2 and COVID-19: Special issue on Coronavirus disease https://www.ijbs.com/v16i10

Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Research Paper
Draft genome sequences of three filamentous cyanobacteria isolated from brackish habitats
Joanne Sarah Boden, Michele Grego, Henk Bolhuis, Patricia Sánchez-Baracaldo
J. Genomics 2021; 9: 20-25. doi:10.7150/jgen.53678
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Review
The Genetic Background of Central Serous Chorioretinopathy: A Review on Central Serous Chorioretinopathy Genes
Konstantinos Giannopoulos, Maria Gazouli, Klio Chatzistefanou, Anthi Bakouli, Marilita M Moschos
J. Genomics 2021; 9: 10-19. doi:10.7150/jgen.55545
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Draft Genome Sequence of Enterobacter sp. AS-1, a Potential Eurytrophic Recombination Host
Yuki Iwasaki, Yuya Itoiri, Sota Ihara, Hironaga Akita, Mamoru Oshiki, Zen-ichiro Kimura
J. Genomics 2021; 9: 6-9. doi:10.7150/jgen.53040
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Isolation, draft genome sequencing and identification of Enterobacter roggenkampii CCI9
Hironaga Akita, Yuya Itoiri, Noriyo Takeda, Zen-ichiro Kimura, Hiroyuki Inoue, Akinori Matsushika
J. Genomics 2021; 9: 1-5. doi:10.7150/jgen.46294
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details