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Research Paper
Ranitidine and finasteride inhibit the synthesis and release of trimethylamine N-oxide and mitigates its cardiovascular and renal damage through modulating gut microbiota
Junfeng Liu, Lingyun Lai, Jiajia Lin, Jiajia Zheng, Xiaoli Nie, Xiaoye Zhu, Jun Xue, Te Liu
Int. J. Biol. Sci. 2020; 16(5): 790-802. doi:10.7150/ijbs.40934
[Abstract] [Full text] [PDF]


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Research Paper
Radiosensitization of Clioquinol Combined with Zinc in the Nasopharyngeal Cancer Stem-like Cells by Inhibiting Autophagy in Vitro and in Vivo
Yuan Ke, Chaoyan Wu, Yifei Zeng, Mengge Chen, Yonghong Li, Conghua Xie, Yunfeng Zhou, Yahua Zhong, Haijun Yu
Int. J. Biol. Sci. 2020; 16(5): 777-789. doi:10.7150/ijbs.40305
[Abstract] [Full text] [PDF]


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Research Paper
Syndecan-4 is a Novel Therapeutic Target for Intervertebral Disc Degeneration via Suppressing JNK/p53 Pathway
Jun Ge, Xiaoqiang Cheng, Chenxi Yuan, Jiale Qian, Chunshen Wu, Cheng Cao, Huilin Yang, Feng Zhou, Jun Zou
Int. J. Biol. Sci. 2020; 16(5): 766-776. doi:10.7150/ijbs.40189
[Abstract] [Full text] [PDF]


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Research Paper
Hepatoprotective Effect of Citrus aurantium L. Against APAP-induced Liver Injury by Regulating Liver Lipid Metabolism and Apoptosis
Yisong Shu, Dan He, Wen Li, Menglei Wang, Siyu Zhao, Linlin Liu, Zhiwen Cao, Rui Liu, Yujuan Huang, Hui Li, Xueqing Yang, Cheng Lu, Yuanyan Liu
Int. J. Biol. Sci. 2020; 16(5): 752-765. doi:10.7150/ijbs.40612
[Abstract] [Full text] [PDF]


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Research Paper
TASP1 Promotes Gallbladder Cancer Cell Proliferation and Metastasis by Up-regulating FAM49B via PI3K/AKT Pathway
Yijian Zhang, Pengcheng Du, Yang Li, Qin Zhu, Xiaoling Song, Shibo Liu, Jiaqi Hao, Liguo Liu, Fatao Liu, Yunping Hu, Lin Jiang, Qiang Ma, Wei Lu, Yingbin Liu
Int. J. Biol. Sci. 2020; 16(5): 739-751. doi:10.7150/ijbs.40516
[Abstract] [Full text] [PDF]


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Review
Multiple Roles of sFRP2 in Cardiac Development and Cardiovascular Disease
Yu Wu, Xinyue Liu, Haoxiao Zheng, Hailan Zhu, Weiyi Mai, Xiaohui Huang, Yuli Huang
Int. J. Biol. Sci. 2020; 16(5): 730-738. doi:10.7150/ijbs.40923
[Abstract] [Full text] [PDF]


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Research Paper
CHIP-mediated ubiquitination of Galectin-1 predicts colorectal cancer prognosis
Weimin Wang, Zhen Zhou, Liangliang Xiang, Mengying Lv, Tengyang Ni, Jianliang Deng, Haibo Wang, Sunagawa Masatara, Yan Zhou, Yanqing Liu
Int. J. Biol. Sci. 2020; 16(4): 719-729. doi:10.7150/ijbs.41125
[Abstract] [Full text] [PDF]


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Research Paper
Septin4 Prevents PDGF-BB-induced HAVSMC Phenotypic Transformation, Proliferation and Migration by Promoting SIRT1-STAT3 Deacetylation and Dephosphorylation
Naijin Zhang, Ying Zhang, Shilong You, Yichen Tian, Saien Lu, Liu Cao, Yingxian Sun
Int. J. Biol. Sci. 2020; 16(4): 708-718. doi:10.7150/ijbs.39843
[Abstract] [Full text] [PDF]


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Research Paper
Epstein-Barr virus miR-BART1-3p suppresses apoptosis and promotes migration of gastric carcinoma cells by targeting DAB2
Kyoungmi Min, Jun Yeob Kim, Suk Kyeong Lee
Int. J. Biol. Sci. 2020; 16(4): 694-707. doi:10.7150/ijbs.36595
[Abstract] [Full text] [PDF]


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Research Paper
NVP-BEZ235 inhibits thyroid cancer growth by p53- dependent/independent p21 upregulation
Banjun Ruan, Wei Liu, Pu Chen, Rongrong Cui, Yu Li, Meiju Ji, Peng Hou, Qi Yang
Int. J. Biol. Sci. 2020; 16(4): 682-693. doi:10.7150/ijbs.37592
[Abstract] [Full text] [PDF]


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Research Paper
Blockage of Kv1.3 regulates macrophage migration in acute liver injury by targeting δ-catenin through RhoA signaling
Baoming Wu, Jun-da Liu, Erbao Bian, Wei Hu, Cheng Huang, Xiaoming Meng, Lei Zhang, Xiongwen Lv, Jun Li
Int. J. Biol. Sci. 2020; 16(4): 671-681. doi:10.7150/ijbs.38950
[Abstract] [Full text] [PDF]


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Research Paper
Silencing MicroRNA-137-3p, which Targets RUNX2 and CXCL12 Prevents Steroid-induced Osteonecrosis of the Femoral Head by Facilitating Osteogenesis and Angiogenesis
Lingchi Kong, Rongtai Zuo, Mengwei Wang, Wenbo Wang, Jia Xu, Yimin Chai, Junjie Guan, Qinglin Kang
Int. J. Biol. Sci. 2020; 16(4): 655-670. doi:10.7150/ijbs.38713
[Abstract] [Full text] [PDF]


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Research Paper
Integrin β3 promotes cardiomyocyte proliferation and attenuates hypoxia-induced apoptosis via regulating the PTEN/Akt/mTOR and ERK1/2 pathways
Lijiang Wei, Qingqing Zhou, Hua Tian, Yifan Su, Guo-hui Fu, Ting Sun
Int. J. Biol. Sci. 2020; 16(4): 644-654. doi:10.7150/ijbs.39414
[Abstract] [Full text] [PDF]


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Research Paper
Tumor Cell-associated Exosomes Robustly Elicit Anti-tumor Immune Responses through Modulating Dendritic Cell Vaccines in Lung Tumor
Ce Wang, Xue Huang, Yingjuan Wu, Jingbo Wang, Furong Li, Guoqing Guo
Int. J. Biol. Sci. 2020; 16(4): 633-643. doi:10.7150/ijbs.38414
[Abstract] [Full text] [PDF]


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Review
Potential roles of extracellular vesicles in the pathophysiology, diagnosis, and treatment of autoimmune diseases
Jing Tian, Giacomo Casella, Yuan Zhang, Abdolmohamad Rostami, Xing Li
Int. J. Biol. Sci. 2020; 16(4): 620-632. doi:10.7150/ijbs.39629
[Abstract] [Full text] [PDF]


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Research Paper
Mifepristone Derivative FZU-00,003 Suppresses Triple-negative Breast Cancer Cell Growth partially via miR-153-KLF5 axis
Rong Liu, Haijun Chen, Ping Zhao, Chuan-Huizi Chen, Huichun Liang, Chuanyu Yang, Zhongmei Zhou, Xu Zhi, Suling Liu, Ceshi Chen
Int. J. Biol. Sci. 2020; 16(4): 611-619. doi:10.7150/ijbs.39491
[Abstract] [Full text] [PDF]

Cover image
Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

Impact factor is 4.067 according to 2019 release of Journal Citation Reports®.
Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Research Paper
Isolation and genomic analysis of 11-aminoundecanoic acid-degrading bacterium Pseudomonas sp. JG-B from nylon 11 enrichment culture
Jocelyn Gatz-Schrupp, Peter Deckard, Benjamin Hufford, Steven Ly, Peter Tupa, Hisako Masuda
J. Genomics 2020; 8: 16-20. doi:10.7150/jgen.42095
[Abstract] [Full text] [PDF]


Research Paper
Draft Genome Sequence of the Symbiotic Frankia sp. strain B2 isolated from root nodules of Casuarina cunninghamiana found in Algeria
Kathia Belaid, Erik Swanson, Alyssa Carré-Mlouka, Valérie Hocher, Sergio Svistoonoff, Djamel Gully, Stephen Simpson, Krystalynne Morris, W. Kelley Thomas, Said Amrani, Louis S. Tisa, Hassen Gherbi
J. Genomics 2020; 8: 11-15. doi:10.7150/jgen.38461
[Abstract] [Full text] [PDF]


Short Research Paper
Draft genome sequences of Salmonella Oslo isolated from seafood and its laboratory generated auxotrophic mutant
Kadeeja Jazeela, Anirban Chakraborty, Praveen Rai, Ballamoole Krishna Kumar, Shabarinath Srikumar, Scot van Nguyen, Daniel Hurley, Seamus Fanning, Indrani Karunasagar, Vijaya Kumar Deekshit
J. Genomics 2020; 8: 7-10. doi:10.7150/jgen.40059
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Genomic Characteristics of the Toxic Bloom-Forming Cyanobacterium Microcystis aeruginosa NIES-102
Haruyo Yamaguchi, Shigekatsu Suzuki, Yasunori Osana, Masanobu Kawachi
J. Genomics 2020; 8: 1-6. doi:10.7150/jgen.40978
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details