toc.jpg

Review
Potential roles of extracellular vesicles in the pathophysiology, diagnosis, and treatment of autoimmune diseases
Jing Tian, Giacomo Casella, Yuan Zhang, Abdolmohamad Rostami, Xing Li
Int. J. Biol. Sci. 2020; 16(4): 620-632. doi:10.7150/ijbs.39629
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Mifepristone Derivative FZU-00,003 Suppresses Triple-negative Breast Cancer Cell Growth partially via miR-153-KLF5 axis
Rong Liu, Haijun Chen, Ping Zhao, Chuan-Huizi Chen, Huichun Liang, Chuanyu Yang, Zhongmei Zhou, Xu Zhi, Suling Liu, Ceshi Chen
Int. J. Biol. Sci. 2020; 16(4): 611-619. doi:10.7150/ijbs.39491
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
The NOTCH1-HEY1 pathway regulates self-renewal and epithelial-mesenchymal transition of salivary adenoid cystic carcinoma cells
Jing Xie, Li-song Lin, Xiao-yu Huang, Rui-huan Gan, Lin-can Ding, Bo-hua Su, Yong Zhao, You-guang Lu, Da-li Zheng
Int. J. Biol. Sci. 2020; 16(4): 598-610. doi:10.7150/ijbs.36407
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Compound C enhances the anticancer effect of aspirin in HER-2-positive breast cancer by regulating lipid metabolism in an AMPK-independent pathway
Ying Wu, Bohua Yan, Wenqin Xu, Lili Guo, Zhe Wang, Guoyin Li, Niuniu Hou, Jian Zhang, Rui Ling
Int. J. Biol. Sci. 2020; 16(4): 583-597. doi:10.7150/ijbs.39936
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Comprehensive understanding of B7 family in gastric cancer: expression profile, association with clinicopathological parameters and downstream targets
Dan Li, Shixin Xiang, Jing Shen, Mingtao Xiao, Yueshui Zhao, Xu Wu, Fukuan Du, Huijiao Ji, Mingxing Li, Qijie Zhao, Parham Jabbarzadeh Kaboli, Xiao Yang, Zhangang Xiao, Bo Qin, Qinglian Wen
Int. J. Biol. Sci. 2020; 16(4): 568-582. doi:10.7150/ijbs.39769
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
The Role of Akt2 in the Protective Effect of Fenofibrate against Diabetic Nephropathy
Yanli Cheng, Xiaoyu Zhang, Fuzhe Ma, Weixia Sun, Wanning Wang, Jinyu Yu, Yue Shi, Lu Cai, Zhonggao Xu
Int. J. Biol. Sci. 2020; 16(4): 553-567. doi:10.7150/ijbs.40643
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Inhibition of PERK Signaling Prevents Against Glucocorticoid-induced Endotheliocyte Apoptosis and Osteonecrosis of the Femoral Head
Yanchun Gao, Hongyi Zhu, Qiyang Wang, Yong Feng, Changqing Zhang
Int. J. Biol. Sci. 2020; 16(4): 543-552. doi:10.7150/ijbs.35256
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Empagliflozin Attenuates Hyperuricemia by Upregulation of ABCG2 via AMPK/AKT/CREB Signaling Pathway in Type 2 Diabetic Mice
Yun-hong Lu, Yun-peng Chang, Ting Li, Fei Han, Chun-jun Li, Xiao-yu Li, Mei Xue, Ying Cheng, Zi-yu Meng, Zhe Han, Bei Sun, Li-ming Chen
Int. J. Biol. Sci. 2020; 16(3): 529-542. doi:10.7150/ijbs.33007
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Upregulation of miR-335-3p by NF-κB Transcriptional Regulation Contributes to the Induction of Pulmonary Arterial Hypertension via APJ during Hypoxia
Junming Fan, Xiaofang Fan, Hui Guang, Xiaoqiong Shan, Qiuyun Tian, Fukun Zhang, Ran Chen, Fangzhou Ye, Hui Quan, Haizeng Zhang, Lu Ding, Zhuohui Gan, Feng Xue, Yongyu Wang, Sunzhong Mao, Lianggang Hu, Yongsheng Gong
Int. J. Biol. Sci. 2020; 16(3): 515-528. doi:10.7150/ijbs.34517
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
TFAP2A Induced ITPKA Serves as an Oncogene and Interacts with DBN1 in Lung Adenocarcinoma
Zhou Guoren, Fan Zhaohui, Zhu Wei, Wang Mei, Wu Yuan, Shi Lin, Xu Xiaoyue, Zhang Xiaomei, Shen Bo
Int. J. Biol. Sci. 2020; 16(3): 504-514. doi:10.7150/ijbs.40435
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
NKILA, a prognostic indicator, inhibits tumor metastasis by suppressing NF-κB/Slug mediated epithelial-mesenchymal transition in hepatocellular carcinoma
Ronggao Chen, Qiyang Cheng, Kwabena Gyabaah Owusu-Ansah, Guangyuan Song, Donghai Jiang, Lin Zhou, Xiao Xu, Jian Wu, Shusen Zheng
Int. J. Biol. Sci. 2020; 16(3): 495-503. doi:10.7150/ijbs.39582
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Ginkgo biloba extract attenuates the disruption of pro-and anti-inflammatory T-cell balance in peripheral blood of arsenicosis patients
Shiqing Xia, Qian Sun, Zhonglan Zou, Yonglian Liu, Xiaolin Fang, Baofei Sun, Shaofeng Wei, Dapeng Wang, Aihua Zhang, Qizhan Liu
Int. J. Biol. Sci. 2020; 16(3): 483-494. doi:10.7150/ijbs.39351
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Exploration of Serum Exosomal LncRNA TBILA and AGAP2-AS1 as Promising Biomarkers for Diagnosis of Non-Small Cell Lung Cancer
Yao Tao, Yuting Tang, Zailin Yang, Futao Wu, Lu Wang, Liyuan Yang, Li Lei, Yipei Jing, Xueke Jiang, Hongjun Jin, Yao Bai, Ling Zhang
Int. J. Biol. Sci. 2020; 16(3): 471-482. doi:10.7150/ijbs.39123
[Abstract] [Full text] [PDF]


toc.jpg

Review
Mucosal-Associated Invariant T cell in liver diseases
Yujue Zhang, Derun Kong, Hua Wang
Int. J. Biol. Sci. 2020; 16(3): 460-470. doi:10.7150/ijbs.39016
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Cdh1 functions as an oncogene by inducing self-renewal of lung cancer stem-like cells via oncogenic pathways
Ting Ye, Jingyuan Li, Zhiwei Sun, Doudou Liu, Bin Zeng, Qiting Zhao, Jianyu Wang, H. Rosie Xing
Int. J. Biol. Sci. 2020; 16(3): 447-459. doi:10.7150/ijbs.38672
[Abstract] [Full text] [PDF]


toc.jpg

Research Paper
Reno-protection of Urine-derived Stem Cells in A Chronic Kidney Disease Rat Model Induced by Renal Ischemia and Nephrotoxicity
Chao Zhang, Sunil K. George, Rongpei Wu, Parth Udayan Thakker, Mehran Abolbashari, Tae-Hyoung Kim, In Kap Ko, Yuanyuan Zhang, Yinghao Sun, John Jackson, Sang Jin Lee, James J. Yoo, Anthony Atala
Int. J. Biol. Sci. 2020; 16(3): 435-446. doi:10.7150/ijbs.37550
[Abstract] [Full text] [PDF]

Cover image
Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

Impact factor is 4.067 according to 2019 release of Journal Citation Reports®.
Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Short Research Paper
Draft genome sequences of Salmonella Oslo isolated from seafood and its laboratory generated auxotrophic mutant
Kadeeja Jazeela, Anirban Chakraborty, Praveen Rai, Ballamoole Krishna Kumar, Shabarinath Srikumar, Scot van Nguyen, Daniel Hurley, Seamus Fanning, Indrani Karunasagar, Vijaya Kumar Deekshit
J. Genomics 2020; 8: 7-10. doi:10.7150/jgen.40059
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Genomic Characteristics of the Toxic Bloom-Forming Cyanobacterium Microcystis aeruginosa NIES-102
Haruyo Yamaguchi, Shigekatsu Suzuki, Yasunori Osana, Masanobu Kawachi
J. Genomics 2020; 8: 1-6. doi:10.7150/jgen.40978
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Genomic characterization of a pectinolytic isolate of Serratia oryzae isolated from lake water
Nicole Hugouvieux-Cotte-Pattat, Cécile Jacot-des-Combes, Jérôme Briolay
J. Genomics 2019; 7: 64-72. doi:10.7150/jgen.38365
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Short Research Paper
Whole Genome Sequence of Marinobacter salarius Strain SMR5, Shown to Promote Growth in its Diatom Host
Mats Töpel, Matthew I.M. Pinder, Oskar N. Johansson, Olga Kourtchenko, Anna Godhe, Adrian K. Clarke
J. Genomics 2019; 7: 60-63. doi:10.7150/jgen.39039
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details