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Review
The Role of Cyclophilins in Inflammatory Bowel Disease and Colorectal Cancer
Lifang Liang, Rongxiao Lin, Ying Xie, Huaqing Lin, Fangyuan Shao, Wen Rui, Hongyuan Chen
Int. J. Biol. Sci. 2021; 17(10): 2548-2560. doi:10.7150/ijbs.58671
[Abstract] [Full text] [PDF]


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Review
New insights into the important roles of tumor cell-intrinsic PD-1
Hongmei Zheng, Yue Ning, Yuting Zhan, Sile Liu, Qiuyuan Wen, Songqing Fan
Int. J. Biol. Sci. 2021; 17(10): 2537-2547. doi:10.7150/ijbs.60114
[Abstract] [Full text] [PDF]


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Research Paper
MUC3A promotes non-small cell lung cancer progression via activating the NFκB pathway and attenuates radiosensitivity
Yingming Sun, Xiaoge Sun, Chengcheng You, Shijing Ma, Yuan Luo, Shan Peng, Fang Tang, Xiaoli Tian, Feng Wang, Zhengrong Huang, Hongnv Yu, Yu Xiao, Xiaoyong Wang, Junhong Zhang, Yan Gong, Conghua Xie
Int. J. Biol. Sci. 2021; 17(10): 2523-2536. doi:10.7150/ijbs.59430
[Abstract] [Full text] [PDF]


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Research Paper
Cantharidin inhibits osteosarcoma proliferation and metastasis by directly targeting miR-214-3p/DKK3 axis to inactivate β-catenin nuclear translocation and LEF1 translation
Shaopu Hu, Junli Chang, Hongfeng Ruan, Wenlan Zhi, Xiaobo Wang, Fulai Zhao, Xiaoping Ma, Xingyuan Sun, Qianqian Liang, Hao Xu, Yongjun Wang, Yanping Yang
Int. J. Biol. Sci. 2021; 17(10): 2504-2522. doi:10.7150/ijbs.51638
[Abstract] [Full text] [PDF]


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Review
Towards Post-Meiotic Sperm Production: Genetic Insight into Human Infertility from Mouse Models
Muhammad Azhar, Saba Altaf, Islam Uddin, Jinbao Cheng, Limin Wu, Xianhong Tong, Weibing Qin, Jianqiang Bao
Int. J. Biol. Sci. 2021; 17(10): 2487-2503. doi:10.7150/ijbs.60384
[Abstract] [Full text] [PDF]


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Review
Emerging Significance and Therapeutic Potential of Extracellular vesicles
Ruhua Luo, Mengmeng Liu, Tiantian Tan, Qian Yang, Yue Wang, Lianhui Men, Liping Zhao, Honghua Zhang, Shuling Wang, Tian Xie, Qingchang Tian
Int. J. Biol. Sci. 2021; 17(10): 2476-2486. doi:10.7150/ijbs.59296
[Abstract] [Full text] [PDF]


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Research Paper
BCAR1 plays critical roles in the formation and immunoevasion of invasive circulating tumor cells in lung adenocarcinoma
Chun-Guo Mao, Sha-sha Jiang, Xiao-yang Wang, Shao-Lin Tao, Bin Jiang, Cheng-Yi Mao, Yan-Lian Yang, Zhi-Yuan Hu, Tan Long, Hua Jin, Qun-You Tan, Yi Huang, Bo Deng
Int. J. Biol. Sci. 2021; 17(10): 2461-2475. doi:10.7150/ijbs.61790
[Abstract] [Full text] [PDF]


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Research Paper
Combination of Ferulic Acid, Ligustrazine and Tetrahydropalmatine attenuates Epithelial-mesenchymal Transformation via Wnt/β-catenin Pathway in Endometriosis
Chengling Zhang, Ying Zhang, Haiying Pan, Yi Tan, Qinghua Wei, Xueshan Dai, Jiahui Wei, Yi Chen
Int. J. Biol. Sci. 2021; 17(10): 2449-2460. doi:10.7150/ijbs.60167
[Abstract] [Full text] [PDF]


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Research Paper
Osteocytes but not osteoblasts directly build mineralized bone structures
Ke Wang, Yinshi Ren, Shuxian Lin, Yan Jing, Chi Ma, Jun Wang, X. Baozhi Yuan, Xianglong Han, Hu Zhao, Zheng Wang, Minghao Zheng, Yin Xiao, Lin Chen, Bjorn Reino Olsen, Jian Q. Feng
Int. J. Biol. Sci. 2021; 17(10): 2430-2448. doi:10.7150/ijbs.61012
[Abstract] [Full text] [PDF]


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Research Paper
USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway
Haiqing He, Lu Yi, Bin Zhang, Bin Yan, Ming Xiao, Jiannan Ren, Dong Zi, Liang Zhu, Zhaohui Zhong, Xiaokun Zhao, Xin Jin, Wei Xiong
Int. J. Biol. Sci. 2021; 17(10): 2417-2429. doi:10.7150/ijbs.54442
[Abstract] [Full text] [PDF]


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Research Paper
Soluble Receptor for Advanced Glycation End-products regulates age-associated Cardiac Fibrosis
Francesco Scavello, Filippo Zeni, Giuseppina Milano, Federica Macrì, Stefania Castiglione, Estella Zuccolo, Alessandro Scopece, Giovanni Pezone, Calogero C. Tedesco, Patrizia Nigro, Genny Degani, Elisa Gambini, Fabrizio Veglia, Laura Popolo, Giulio Pompilio, Gualtiero I. Colombo, Marco E. Bianchi, Angela Raucci
Int. J. Biol. Sci. 2021; 17(10): 2399-2416. doi:10.7150/ijbs.56379
[Abstract] [Full text] [PDF]


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Research Paper
Cx43 deficiency confers EMT-mediated tamoxifen resistance to breast cancer via c-Src/PI3K/Akt pathway
Deng-Pan Wu, Yan Zhou, Li-Xiang Hou, Xiao-Xiao Zhu, Wen Yi, Si-Man Yang, Tian-Yu Lin, Jin-Lan Huang, Bei Zhang, Xiao-Xing Yin
Int. J. Biol. Sci. 2021; 17(10): 2380-2398. doi:10.7150/ijbs.55453
[Abstract] [Full text] [PDF]


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Research Paper
Recombinant human bone morphogenetic protein 2 and 7 inhibit the degeneration of intervertebral discs by blocking the Puma-dependent apoptotic signaling
Shiwei Xie, Chenyang Zhao, Wei Chen, Gengwu Li, Zhiwei Xiong, Xiangjun Tang, Fan Zhang, Heng Xiao
Int. J. Biol. Sci. 2021; 17(9): 2367-2379. doi:10.7150/ijbs.56823
[Abstract] [Full text] [PDF]


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Research Paper
Inhibition of Death-associated Protein Kinase 1 protects against Epileptic Seizures in mice
Chen-Ling Gan, Yulian Zou, Yongfang Xia, Tao Zhang, Dongmei Chen, Guihua Lan, Yingxue Mei, Long Wang, Xindong Shui, Li Hu, Hekun Liu, Tae Ho Lee
Int. J. Biol. Sci. 2021; 17(9): 2356-2366. doi:10.7150/ijbs.59922
[Abstract] [Full text] [PDF]


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Research Paper
Capivasertib restricts SARS-CoV-2 cellular entry: a potential clinical application for COVID-19
Fang Sun, Chenglin Mu, Hang Fai Kwok, Jiyuan Xu, Yingliang Wu, Wanhong Liu, Jean-Marc Sabatier, Cédric Annweiler, Xugang Li, Zhijian Cao, Yingqiu Xie
Int. J. Biol. Sci. 2021; 17(9): 2348-2355. doi:10.7150/ijbs.57810
[Abstract] [Full text] [PDF]


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Research Paper
High ovarian GDF-8 levels contribute to elevated estradiol production in ovarian hyperstimulation syndrome by stimulating aromatase expression
Lanlan Fang, Yang Yan, Sijia Wang, Yanjie Guo, Yiran Li, Qiongqiong Jia, Xiaoyu Han, Boqun Liu, Jung-Chien Cheng, Ying-Pu Sun
Int. J. Biol. Sci. 2021; 17(9): 2338-2347. doi:10.7150/ijbs.60332
[Abstract] [Full text] [PDF]

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Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

new Latest impact factor 4.858 according to 2020 release of JCR®.

new🆘The continued global battle against SARS-CoV-2 and COVID-19: Special issue on Coronavirus disease https://www.ijbs.com/v17i6

🆘 The global battle against SARS-CoV-2 and COVID-19: Special issue on Coronavirus disease https://www.ijbs.com/v16i10

Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Research Paper
Analysis of Genome Sequences of Coagulase-Negative Staphylococci Isolates from South Africa and Nigeria Highlighted Environmentally Driven Heterogeneity
Tawanda Elias Maguvu, Adegboyega Oyedele Oladipo, Cornelius Carlos Bezuidenhout
J. Genomics 2021; 9: 26-37. doi:10.7150/jgen.53019
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Draft genome sequences of three filamentous cyanobacteria isolated from brackish habitats
Joanne Sarah Boden, Michele Grego, Henk Bolhuis, Patricia Sánchez-Baracaldo
J. Genomics 2021; 9: 20-25. doi:10.7150/jgen.53678
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Review
The Genetic Background of Central Serous Chorioretinopathy: A Review on Central Serous Chorioretinopathy Genes
Konstantinos Giannopoulos, Maria Gazouli, Klio Chatzistefanou, Anthi Bakouli, Marilita M Moschos
J. Genomics 2021; 9: 10-19. doi:10.7150/jgen.55545
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Draft Genome Sequence of Enterobacter sp. AS-1, a Potential Eurytrophic Recombination Host
Yuki Iwasaki, Yuya Itoiri, Sota Ihara, Hironaga Akita, Mamoru Oshiki, Zen-ichiro Kimura
J. Genomics 2021; 9: 6-9. doi:10.7150/jgen.53040
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details