Int J Biol Sci
2014; 10(6):596-601.
doi:10.7150/ijbs.8780 This issueCite
Review
Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment
Michael V. Fiandalo, John Wilton, James L. Mohler✉
Department of Urology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
✉ Corresponding author: James L. Mohler MD. Department of Urology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263. Telephone: (716) 845-8433 Fax: (716) 845-3300 Email: James.Mohlerorg.
Citation:
Fiandalo MV, Wilton J, Mohler JL. Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment. Int J Biol Sci 2014; 10(6):596-601. doi:10.7150/ijbs.8780. https://www.ijbs.com/v10p0596.htm
Almost all men who present with advanced prostate cancer (CaP) and many men who fail potentially curative therapy are treated with androgen deprivation therapy (ADT). ADT is not curative and CaP recurs as the lethal phenotype. The goal of this review is to describe the evolution of adrenal androgen blockade, how new androgen measurement methods have furthered understanding of androgen metabolism, and how further understanding of the backdoor pathway of androgen metabolism may lead to interventions that extend survival even more.
Fiandalo, M.V., Wilton, J., Mohler, J.L. (2014). Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment. International Journal of Biological Sciences, 10(6), 596-601. https://doi.org/10.7150/ijbs.8780.
ACS
Fiandalo, M.V.; Wilton, J.; Mohler, J.L. Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment. Int. J. Biol. Sci. 2014, 10 (6), 596-601. DOI: 10.7150/ijbs.8780.
NLM
Fiandalo MV, Wilton J, Mohler JL. Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment. Int J Biol Sci 2014; 10(6):596-601. doi:10.7150/ijbs.8780. https://www.ijbs.com/v10p0596.htm
CSE
Fiandalo MV, Wilton J, Mohler JL. 2014. Roles for the Backdoor Pathway of Androgen Metabolism in Prostate Cancer Response to Castration and Drug Treatment. Int J Biol Sci. 10(6):596-601.