Volume 21, Issue 9

open access Global reach, higher impact

◂ Last issue Next issue ▸ Archive Cover PDF

Volume 21 (9); 2025

Research Papers

Interferon Regulatory Factor 4 Recruits Immature B Cells to Signal Tertiary Lymphoid Structure Immaturity and Progression of Clear Cell Renal Cell Carcinoma
Siqi Zhou, Shiqi Ye, Liang Chen, Qintao Ge, Jiahe Lu, Aihetaimujiang Anwaier, Xi Tian, Zhongyuan Wang, Shuxuan Zhu, Kun Chang, Jianfeng Yang, Tian Li, Hailiang Zhang, Dingwei Ye, Jianfeng Xiang, Wenhao Xu
Int. J. Biol. Sci. 2025; 21(9): 3827-3851. doi:10.7150/ijbs.113737
Full text PDF PubMed PMC

APT1-derived depalmitoylation of CD36 alleviates diabetes-induced lipotoxicity in podocytes
Juan Wang, Jijia Hu, Hongtu Hu, Qian Guan, Zijing Zhu, Qian Yang, Guohua Ding
Int. J. Biol. Sci. 2025; 21(9): 3852-3866. doi:10.7150/ijbs.109220
Full text PDF PubMed PMC

Polystyrene Nanoplastics Exacerbate HFD-induced MASLD by Reducing Cathepsin Activity and Triggering Large Vacuole Formation via Impaired Lysosomal Acidification
Jiwon Ahn, Kajung Ryu, Hyerin Kim, Hwi Won Seo, Minsu Jang, Seung-Hyun Kim, Yunho Park, Myung Jin Son, Ho-Joon Lee, Ok-Seon Kwon, Kyung-Sook Chung
Int. J. Biol. Sci. 2025; 21(9): 3867-3885. doi:10.7150/ijbs.108268
Full text PDF PubMed PMC

Unlocking the Puzzle of Mammalian Transfection: The Role of the RNA-sensing-Mediated Interferon Response in the Cellular Defense Against Foreign DNA Intrusion
Xiaoyu Li, Yicen Zhou, Jie Wei, Wei Sun, Ligang Fan, Jian Yan
Int. J. Biol. Sci. 2025; 21(9): 3886-3900. doi:10.7150/ijbs.107510
Full text PDF PubMed PMC

Epithelial DPP4 promotes Ang II-driven renal fibrosis by targeting ACE2 activity in the renin-angiotensin system
Yingying Zhang, Ruizhi Tan, Lehao Wu, Dan Zhao, Cheng Zhong, Chenggong Luo, Jeff Yat-Fai Chung, Patrick Ming-Kuen Tang, Chen Yu
Int. J. Biol. Sci. 2025; 21(9): 3901-3916. doi:10.7150/ijbs.106418
Full text PDF PubMed PMC

Melatonin Ameliorate neuroinflammation in activated microglia through the Aryl hydrocarbon-Nrf2 axis
Meei-Ling Sheu†, Cheng-Ning Yang, Liang-Yi Pan, Jason Sheehan, Liang-Yu Pan, Weir-Chiang You, Chien-Chia Wang, Ying Ju Chen, Hong-Shiu Chen†, Hung-Chuan Pan
Int. J. Biol. Sci. 2025; 21(9): 3917-3933. doi:10.7150/ijbs.105081
Full text PDF PubMed PMC

WNT5B regulates myogenesis and fiber type conversion by affecting mRNA stability
Danyang Fan, Yilong Yao, Chao Yan, Fanqinyu Li, Yalan Yang, Bingkun Xie, Zhonglin Tang
Int. J. Biol. Sci. 2025; 21(9): 3934-3948. doi:10.7150/ijbs.102309
Full text PDF PubMed PMC

Signature-based repurposed drugs resemble the inhibition of TGFβ-induced NDRG1 as potential therapeutics for triple-negative breast cancer
Araceli López-Tejada, Jose L. Blaya-Cánovas, Francisca E. Cara, Jesús Calahorra, César Ramírez-Tortosa, Isabel Blancas, Violeta Delgado-Almenta, Fabiola Muñoz-Parra, Marta Ávalos-Moreno, Ana Sánchez, Adrián González-González, Juan A. Marchal, Carmen Griñán-Lisón, Sergio Granados-Principal
Int. J. Biol. Sci. 2025; 21(9): 3949-3967. doi:10.7150/ijbs.112645
Full text PDF PubMed PMC

Multi-cohort validation of a lipid metabolism and ferroptosis-associated index for prognosis and immunotherapy response prediction in hormone receptor-positive breast cancer
Cheng Zeng, Jiani Wang, Shen Zhao, Yuhan Wei, Yalong Qi, Shuning Liu, Yuanyi Wang, Hewei Ge, Xiaoqi Yang, Yujing Tan, Yizhou Jiang, Haili Qian, Fei Ma
Int. J. Biol. Sci. 2025; 21(9): 3968-3992. doi:10.7150/ijbs.113213
Full text PDF PubMed PMC

Protein Arginine Methyltransferase 1-mediated Histone H4R3 Dimethyl Asymmetric enhances Epidermal Growth Factor Receptor signaling to promote Peritoneal Fibrosis
Hui Chen, Yingfeng Shi, Jinqing Li, Qin Zhong, Xiaoyan Ma, Yan Hu, Yishu Wang, Daofang Jiang, Xialin Li, Shasha Zhang, Shougang Zhuang, Na Liu
Int. J. Biol. Sci. 2025; 21(9): 4010-4026. doi:10.7150/ijbs.114037
Full text PDF PubMed PMC

Exogenous SPD inhibits trastuzumab-mediated cardiomyocyte pyroptosis through SIRT3-regulated mitochondrial quality control
Xue Yu, Yan Yang, Tianzuo Chen, Qianbing Wang, Zitong Wang, Xi Gao, Qianxue Wang, Jinxiang Guo, Yuqin Wang, Yajie Zhao, Shilin Wang, Wei Lu, Xing Luo, Tielei Gao, Jiayuan Kou, Hong Li, Liming Yang
Int. J. Biol. Sci. 2025; 21(9): 4027-4050. doi:10.7150/ijbs.110580
Full text PDF PubMed PMC

Arsenic disrupts H3K9me3 and H3K27me3 balance by biasing PRC2.1 and PRC2.2 activity via PALI1 inhibition in carcinogenesis
Haoyan Ji, Millie Elangbam, Yiran Qiu, Jessica Bamrah, Wenxuan Zhang, Aashna Pawar, Chitra Thakur, Fei Chen, Ziwei Wang
Int. J. Biol. Sci. 2025; 21(9): 4069-4080. doi:10.7150/ijbs.115605
Full text PDF PubMed PMC

Promoter Hyper-methylation of ZNF662 Restrains its Tumor Suppressing Function in Triple-Negative Breast Cancer Through Regulating NGF Signaling Axis
Renjie Yu, Xi Peng, Zhaobo Cheng, Yue Wu, Huan Rong, Lin Yi, Jing Ran, Chaoqun Deng, Xiangyi Zhou, Ruijie Ming, Ningning Zhang, Xiaoyu Liu, Xiaohua Zeng, Yun Xiao, Xue Wang, Yongzhong Wu, Bo Qin, Tingxiu Xiang
Int. J. Biol. Sci. 2025; 21(9): 4081-4097. doi:10.7150/ijbs.102940
Full text PDF PubMed PMC

Apelin facilitates integrin αvβ3 production and enhances metastasis in prostate cancer by activating STAT3 and inhibiting miR-8070
Tien-Huang Lin, Shan-Chi Liu, Yuan-Li Huang, Chao-Yang Lai, Xiu-Yuan He, Chun-Hao Tsai, Yi-Chin Fong, Hsi-Chin Wu, An-Chen Chang, Yen-You Lin, Chih-Hsueh Lin, Chih-Hsin Tang
Int. J. Biol. Sci. 2025; 21(9): 4117-4128. doi:10.7150/ijbs.113161
Full text PDF PubMed PMC

Acute Exposure to Cadmium Triggers NCOA4-Mediated Ferritinophagy and Ferroptosis in Never-Smokers Oral Cancer Cells
Lavinia Petriaggi, Emanuele Giorgio, Stefania Bulotta, Alessandro Antonelli, Sonia Bonacci, Marialaura Frisina, Antonio Procopio, Licia Elvira Prestagiacomo, Annarita Giuliano, Marco Gaspari, Gianluca Santamaria, Giorgia Federico, Cristiana Galeano, Giuseppe Natali, Amerigo Giudice, Francesco Costanzo, Anna Martina Battaglia, Flavia Biamonte
Int. J. Biol. Sci. 2025; 21(9): 4131-4152. doi:10.7150/ijbs.111228
Full text PDF PubMed PMC

Cancer-associated Fibroblast-like Cells Promote Osteosarcoma Metastasis by Upregulation of Phosphoserine Aminotransferase 1 and Activation of the mTOR/S6K Pathway
Liwen Feng, Guangqin Xiao, Yuting Chen, Ting Ye, Li Fan, Yuxiu Xie, Ting Mei, Lei Wang, Jingjing Ge, Chengzhi Ye, Jing Chen
Int. J. Biol. Sci. 2025; 21(9): 4153-4171. doi:10.7150/ijbs.109169
Full text PDF PubMed PMC

NASP Promotes Triple-negative Breast Cancer Progression and Metastasis by Stabilizing YAP in a USP15-Dependent Way
Wenfang Zheng, Qifeng Luo, Xuehui Wang, Xiqian Zhou, Danrong Ye, Kaiyao Hua, Lin Fang
Int. J. Biol. Sci. 2025; 21(9): 4172-4186. doi:10.7150/ijbs.99438
Full text PDF PubMed PMC

SESN2 inhibits tubular exosome secretion and diabetic kidney disease progression by restoring the autophagy‒lysosome pathway
Zongji Zheng, Jiaqi Chen, Xiaoquan Xue, Xiaoqin Ma, Shuting Zhang, Ming Wang, Yaoming Xue, Yijie Jia
Int. J. Biol. Sci. 2025; 21(9): 4215-4230. doi:10.7150/ijbs.109799
Full text PDF PubMed PMC

Enhancing CAR-T Cell Metabolic Fitness and Memory Phenotype for Improved Efficacy against Hepatocellular Carcinoma
Jinqi You, Xinyi Yang, Jingjing Zhao, Hao Chen, Yan Tang, Dijun Ouyang, Yuanyuan Liu, Yan Wang, Songzuo Xie, Yuanyuan Chen, Jinghao Liao, Tong Xiang, Jianchuan Xia, Chaopin Yang, Desheng Weng
Int. J. Biol. Sci. 2025; 21(9): 4231-4251. doi:10.7150/ijbs.110406
Full text PDF PubMed PMC

Coupling of glucose metabolism with mitophagy via O-GlcNAcylation of PINK1
Zhiwei Xu, Xiangzheng Gao, Dade Rong, Jingyao Wang, Liangliang Gao, Mingzhu Tang, Yiguan Chen, Yichi Zhang, Liming Xie, Liming Wang, Guang Lu, Jia-Hong Lu, Wei Liu, Han-Ming Shen
Int. J. Biol. Sci. 2025; 21(9): 4252-4269. doi:10.7150/ijbs.112672
Full text PDF PubMed PMC

Reviews

Deubiquitinating enzymes: Key regulators of ferroptosis and pyroptosis and novel targets for cancer intervention
Sheng-Kai Hsu, I-Ying Kuo, Pin-Yuan Lin, Chon-Kit Chou, Ching-Chung Ko, Wen-Tsan Chang, Chien-Chih Chiu
Int. J. Biol. Sci. 2025; 21(9): 3993-4009. doi:10.7150/ijbs.111867
Full text PDF PubMed PMC

Interaction of Nanomaterials with Nucleic Acids and Their Applications in Nucleic Acid Analysis
Jiale Wang, Kai Li, Fukai Li, Xinran Li, Jian Zhou, Mengrui Yang, Xiao Zhang, Mengyu Wang, Liang Li
Int. J. Biol. Sci. 2025; 21(9): 4051-4068. doi:10.7150/ijbs.113309
Full text PDF PubMed PMC

Orchestration of Tumor-Associated Macrophages in the Tumor Cell-Macrophage-CD8⁺ T Cell Loop for Cancer Immunotherapy
Lin He, Paul Kwong-Hang Tam, Chu-Xia Deng
Int. J. Biol. Sci. 2025; 21(9): 4098-4116. doi:10.7150/ijbs.115932
Full text PDF PubMed PMC

Decoding the Tumor Microenvironment: Exosome-Mediated Macrophage Polarization and Therapeutic Frontiers
Yilin Li, Jiaqi You, Zifang Zou, Guanghao Sun, Yuqing Shi, Yanbin Sun, Shun Xu, Xin Zhang
Int. J. Biol. Sci. 2025; 21(9): 4187-4214. doi:10.7150/ijbs.114222
Full text PDF PubMed PMC

Deubiquitylating Enzymes in Hepatocellular Carcinoma
Xingyu Mi, Qingfeng Li, Guo Long, Yilin Pan, Yulin Xie, Shiqi Lu, Liang Xiao, Jianing Tang, Ledu Zhou
Int. J. Biol. Sci. 2025; 21(9): 4270-4292. doi:10.7150/ijbs.113193
Full text PDF PubMed PMC

Erratum

cDCBLD2 mediates sorafenib resistance in hepatocellular carcinoma by sponging miR-345-5p binding to the TOP2A coding sequence: Erratum
YeLing Ruan, TianYi Chen, LongBo Zheng, JingWei Cai, Hu Zhao, YaLi Wang, LiYe Tao, JunJie Xu, Lin Ji, XiuJun Cai
Int. J. Biol. Sci. 2025; 21(9): 4129-4130. doi:10.7150/ijbs.113876
Full text PDF PubMed PMC