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Volume 21 (15); 2025

Research Papers

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Remodeling Cell Adhesion Releases Cardiac Potential of Human Pluripotent Stem Cells with Continuous Proliferation and Accelerated Maturation
Weiwei Liu, Chuyu Liu, Qian Wang, Chengwu Li, Jiaxian Wang, Ning-Yi Shao, Guokai Chen
Int. J. Biol. Sci. 2025; 21(15): 6542-6558. doi:10.7150/ijbs.120853
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Quercetin Protects Against Transmissible Gastroenteritis Virus-Induced Intestinal Inflammation by Modulating Mitophagy-Driven Mitochondrial Dysfunction
Kang Wang, Zhentao He, Yan Li, Bing Yu, Yuheng Luo, Xiangbing Mao, Hui Yan, Aimin Wu, Junqiu Luo, Jun He
Int. J. Biol. Sci. 2025; 21(15): 6559-6579. doi:10.7150/ijbs.116855
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How relevant is the mouse model for understanding human sex determination?
Francisco Brito, Chloé Mayère, Aurélie Lardenois, Violaine Regard, Sylwia Czukiewska, Cyril Djari, Pauline Sararols, Yasmine Neirijnck, Françoise Kühne, Séverine Mazaud-Guittot, Susana M Chuva de Sousa Lopes, Frédéric Chalmel, Antoine D Rolland, Serge Nef
Int. J. Biol. Sci. 2025; 21(15): 6599-6615. doi:10.7150/ijbs.90231
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Targeting FTL regulates ferroptosis and remodels lymph node metastasis microenvironment in esophageal squamous cell carcinoma
Shuyue Zheng, Yunzhi Liu, Baifeng Zhang, Jiao Huang, Xiaona Fang, Cuicui Huang, Lanqi Gong, Jie Luo, Yuma Yang, Shan Liu, Ching Ngar Wong, Jinlin Huang, Shanshan Li, Yanan Tan, Qingyun Chen, Yanru Qin, Xin-Yuan Guan
Int. J. Biol. Sci. 2025; 21(15): 6616-6632. doi:10.7150/ijbs.112017
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PTEN-deficient, chromosomal instability colorectal cancer is hypersensitive to STAT3 inhibition
Guowen Ren, Yue Pu, Xiumei Zhang, Jinghong Chen, Eun Ju Yang, Shishi Tao, Li-Jie Chen, Wenli Zhu, Kin long Chan, Guanghui Luo, Chuxia Deng, Joong Sup Shim
Int. J. Biol. Sci. 2025; 21(15): 6633-6648. doi:10.7150/ijbs.111254
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Single-cell and spatial transcriptomic analysis reveal cellular heterogeneity and cancer cell-intrinsic major histocompatibility complex II expression in urothelial carcinoma
Shengwei Xiong, Jian Fan, Cong Huang, Shiming He, Yuan Liang, Qi Zhang, Bin Guo, Yucai Wu, Mancheng Xia, Fangzhou Zhao, Weimin Ci, Liqun Zhou, Yanqing Gong, Xuesong Li
Int. J. Biol. Sci. 2025; 21(15): 6649-6673. doi:10.7150/ijbs.114618
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ETV4 interacts with LOXL2 to induce epigenetic activation of NID1 during colorectal cancer progression
Tinghui Jiang, Xin Liu, Hao Liu, Kailong Du, Yitao Wang, Hui Fan, Ying Zhang, Lin Cui, Hewei Zhang, Chundong Zhang, Yong Zhu, Zhongyu Liu, Youquan Bu, Yunlong Lei
Int. J. Biol. Sci. 2025; 21(15): 6674-6696. doi:10.7150/ijbs.116383
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α-hederin Targets USP5 to Inhibit Colorectal Tumorigenesis by Disrupting STAT3 Deubiquitination
Hui Feng, Qijuan Wang, Liu Li, Lihuiping Tao, Shuhong Zeng, Ziwen Li, Minmin Fan, Chengtao Yu, Dongdong Sun, Weixing Shen, Haibo Cheng
Int. J. Biol. Sci. 2025; 21(15): 6697-6722. doi:10.7150/ijbs.119868
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N-Homocysteinylation of HMGB1/2 Promotes Corpus Cavernosum Endothelial Senescence in Erectile Dysfunction
Peng Hu, Sen Fu, Beining Li, Xiaoyu Zhu, Bocheng Tu, Chenglin Han, Jiaxin Wang, Wenchao Xu, Xinqi Liu, Shiqing Zhu, Chengwei Wang, Zhiyao Deng, Yuxuan Deng, Sheng Xin, Jingyu Song, Jihong Liu, Kai Cui
Int. J. Biol. Sci. 2025; 21(15): 6723-6744. doi:10.7150/ijbs.119514
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CCL2 supports human hepatocytes long-term expansion for bioartificial liver therapy to relieve acute liver failure and extrahepatic complications
Zibin Zhan, Xuewen Liu, Min Zeng, Zehua Li, Yue Zhang, Xueyan Qiao, Xinming Li, Xianfeng Xia, Kunhao Bai, Fanhong Zeng, Yi Gao, Jun Weng
Int. J. Biol. Sci. 2025; 21(15): 6759-6774. doi:10.7150/ijbs.115293
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SYT4 Interacts with PSMC6 to Facilitate Malignant Progression in Gastric Carcinoma via Activating Wnt/β-catenin Signaling
Wen Huang, Rongkui Luo, Huimei Wang, Shuo Yang, Zixiang Yu, Yufeng Liu, Huaiyu Liang, Yanyan Shen, Xiaolei Zhang, Licheng Shen, Sujie Akesu, Chen Xu, Yingyong Hou
Int. J. Biol. Sci. 2025; 21(15): 6775-6793. doi:10.7150/ijbs.118672
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GDF15 Drives Glioblastoma Radioresistance by Inhibiting Ferroptosis and Remodeling the Immune Microenvironment
Wenqing Feng, Yantan Liu, Qinghua Zhang, Shushu Hu, Dehuang Xie, Peixin Tan, Yuan Lei, Chen Chen, Chen Ren, Shasha Du
Int. J. Biol. Sci. 2025; 21(15): 6794-6807. doi:10.7150/ijbs.115721
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HDAC4/MybL1/YAP novel signaling axis is required for pancreatic cancer metastasis to the liver
Mouad Edderkaoui, Omer H.M. Elmadbouh, Adrian Lim, Yan Ou, Dina Hauptschein, Ankita Guha, Abdo Darwish, Vinicius F. Calsavara, Ramachandran Murali, Neil Bhowmick, Arsen Osipov, Angela J. Mathison, Raul Urrutia, Qiang Wang, Stephen J. Pandol
Int. J. Biol. Sci. 2025; 21(15): 6907-6925. doi:10.7150/ijbs.102132
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TGF-β1/SMAD3-mediated Non-canonical Hedgehog Signaling Promotes Pancreatic Stellate Cell Activation and Fibrosis in Chronic Pancreatitis
Linrui Peng, Yuchen Hu, Xiaoying Zhang, Chunlu Tan, Chan Yang, Tingting Liu, Pawel E Ferdek, Shufen Yin, Liu Wang, Wei Huang, Yuwei Zhang
Int. J. Biol. Sci. 2025; 21(15): 6978-6996. doi:10.7150/ijbs.108149
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GDF10 attenuates MASH progression by restoring quiescent hepatic stellate cells via competitive inhibition of TGF-β/SMAD2 signaling
Yajie Peng, Hongyan Lei, Jiahui Zhao, Huajuan Wang, Zheng Luo, Dixin Wang, Shujun Shi, Tianyi Wang, Jin Li, Zhiqing Pang, Bo Wang, Xuelian Xiong
Int. J. Biol. Sci. 2025; 21(15): 6997-7012. doi:10.7150/ijbs.123784
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Activation of GSDME by all-trans-retinal increases sensitivity to photoreceptor ferroptosis
Bo Yang, Kunhuan Yang, Yuling Chen, Ruitong Xi, Jiahuai Han, Shiying Li, Jingmeng Chen, Yalin Wu
Int. J. Biol. Sci. 2025; 21(15): 7029-7042. doi:10.7150/ijbs.114187
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Synergistic Anti-Tumor Effects of Sulfatinib and Kaempferol on Pancreatic Neuroendocrine Tumors via CALCA-mediated PI3K/AKT/mTOR Pathway
Lingyi Chen, Pengfei Liu, Fengjuan Chen, Bingyan Xue, Xu Han, Lijun Yan, Jianan Bai, Xiaoya Li, Min Liu, Ye Tian, Mujie Ye, Qiyun Tang
Int. J. Biol. Sci. 2025; 21(15): 7043-7062. doi:10.7150/ijbs.119176
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Combination of FTO and BTK inhibitors synergistically suppresses the malignancy of breast cancer cells
Abdulaziz Ahmed A. Saad, Lichen Ge, Haoran Wang, Yan Xia, Jianing Li, Shiyao Qiao, Cheng Yi, Xiansong Wang, Zhaotong Wang, Dan Zhou, Hongsheng Wang
Int. J. Biol. Sci. 2025; 21(15): 7063-7085. doi:10.7150/ijbs.117999
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Reviews

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Macrophage Immunometabolism in Pulmonary Homeostasis and Chronic Lung Diseases
Cong Xie, Maimaititusun Yalikun, Zhenhui Ruan, Hang Yu, Xi Huang, Huahe Zhu, Wenglam Choi, Qingli Luo, Zhen Gao, Jingcheng Dong
Int. J. Biol. Sci. 2025; 21(15): 6580-6598. doi:10.7150/ijbs.123492
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Cellular Senescence in Endometrium: A Pivotal Regulator in Physiological Remodeling and Pathological Disorders
Zi-Yang Yan, Wen-Jie Zhou, Jiang-Feng Ye, Feng Xie, Chun-Xue Zhang, Ming-Qing Li
Int. J. Biol. Sci. 2025; 21(15): 6745-6758. doi:10.7150/ijbs.123036
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Extracellular matrix dysregulation in aging, calcification, and cancer diseases: insights into cellular senescence, inflammation, and novel therapeutic strategies
Diego Liviu Boaru, Diego De Leon-Oliva, Patricia De Castro-Martinez, Cielo Garcia-Montero, Oscar Fraile-Martinez, Beatriz García-González, Isabel Pérez-González, Majd N. Michael Alhaddadin, Silvestra Barrena-Blázquez, Laura Lopez-Gonzalez, Basilio de la Torre, Leonel Pekarek, Miguel A Saez, Laura Ríos-Espinosa, Tatiana Pekarek, Roberto Fernández-Baillo Gallego de la Sacristana, Mauricio Hernández-Fernández, Carlos Casanova, Ana Castel-Oñate, Natalio Garcia-Honduvilla, Julia Buján, Raul Diaz-Pedrero, Melchor Alvarez-Mon, Miguel A Ortega
Int. J. Biol. Sci. 2025; 21(15): 6808-6881. doi:10.7150/ijbs.119301
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Precision Reprogramming in CAR-T Cell Therapy: Innovations, Challenges, and Future Directions of Advanced Gene Editing
Zimo Jia, Jiajin Wu, Jiyue Zhang, Peixian Zheng, Haoxuan Zhang, Yiqin Lin, Tao Pan, Meng Wu, Yuqin Song
Int. J. Biol. Sci. 2025; 21(15): 6884-6906. doi:10.7150/ijbs.124144
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Metabolic Reprogramming in Urological Tumors: New Perspectives from Tumor Metabolic Phenotypes to Therapeutic Targets
Zhuohang Li, Lin Yang, Weijia Li, Wenxue Huang, Cunzhen Ma, Boyuan Sun, Xunguo Yang, Haoxiang Xu, Zhibiao Li, Jie Zhao, Bisheng Cheng, Peng Wu
Int. J. Biol. Sci. 2025; 21(15): 6926-6951. doi:10.7150/ijbs.123647
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Demystifying metabolic‒immune crosstalk: how amino acid metabolic reprogramming shapes the malignant phenotype and macrophage polarization of biliary and pancreatic tumors
Jinglei Zhang, Zhuohuan Chu, Jiawen Li, Lu Xie, Cong Ding, Zihui An, Xiang Wang, Hangbin Jin, Xiaofeng Zhang, Qiang Liu, Jianfeng Yang
Int. J. Biol. Sci. 2025; 21(15): 6952-6977. doi:10.7150/ijbs.122325
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Venous Malformations: Unraveling Latest Mechanisms and Bridging Gaps in Targeted Therapy Development
Xuan Jiang, Li Hu, Jiayi Lai, Shengfang Ge, Hui Chen, Xi Yang, Xiaoxi Lin
Int. J. Biol. Sci. 2025; 21(15): 7013-7028. doi:10.7150/ijbs.122569
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SIRT1 in Liver Diseases: Mechanistic Insights and Therapeutic Prospects
Fucheng Zuo, Junfa Yang, Qixiang Wu, Yaru Yang, Huan Zhou, Yuansong Sun, Tao Xu
Int. J. Biol. Sci. 2025; 21(15): 7086-7103. doi:10.7150/ijbs.117669
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Proteasome: Role in T Cell Function Regulation
Dongyang Tang, Xiaoran Wu, Josh Haipeng Lei, Yunfeng Qiao, Chu-Xia Deng
Int. J. Biol. Sci. 2025; 21(15): 7104-7117. doi:10.7150/ijbs.125134
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