Int J Biol Sci 2019; 15(9):1955-1961. doi:10.7150/ijbs.34838 This issue

Review

Krüppel-like Factor 15: A Potential Therapeutic Target For Kidney Disease

Lefeng Wang1, Weiqiang Lin1,2,✉, Jianghua Chen1,✉

1. The Kidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
2. Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310029, China.

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Citation:
Wang L, Lin W, Chen J. Krüppel-like Factor 15: A Potential Therapeutic Target For Kidney Disease. Int J Biol Sci 2019; 15(9):1955-1961. doi:10.7150/ijbs.34838. Available from https://www.ijbs.com/v15p1955.htm

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Abstract

Graphic abstract

Krüppel-like factor 15 (KLF15) is a zinc-finger transcription factor highly expressed in the glomeruli and interstitial cells of kidneys. An increasing number of studies have demonstrated a critical role for KLF15 in the kidney, involving tubular physiology, podocyte injury, renal fibrosis, and mesangial pathology. In this review, we discuss recent advances and update our overview of the functions of KLF15 in kidney biology, hoping to provide new perspectives on the progression and therapy of Chronic Kidney Disease (CKD). A better understanding of KLF15 with respect to its diverse roles in specific cells or diseases will be beneficial in pursuing novel therapeutic targets and moving forward to precision medicine.

Keywords: Krüppel-like factor 15, Kidney disease, Podocyte differentiation, Mesangial cell, Renal fibrosis