Int J Biol Sci 2020; 16(16):3174-3183. doi:10.7150/ijbs.49535

Review

Emerging Roles of SIRT1 in Alcoholic Liver Disease

Ruixue Ren1, Ziming Wang1, Miaomiao Wu2,3, Hua Wang1,2,3✉

1. Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China
2. School of Pharmacy, Institute of Liver Diseases, Anhui Medical University, Hefei 230032, Anhui, China
3. Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei 230032, Anhui, China

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Citation:
Ren R, Wang Z, Wu M, Wang H. Emerging Roles of SIRT1 in Alcoholic Liver Disease. Int J Biol Sci 2020; 16(16):3174-3183. doi:10.7150/ijbs.49535. Available from https://www.ijbs.com/v16p3174.htm

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Abstract

Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide with a wide spectrum of liver pathologies ranging from simple steatosis to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. It has been demonstrated that ALD is mediated in whole or in part by a central signaling molecule sirtuin 1 (SIRT1), a conserved class III histone deacetylase.SIRT1 plays beneficial roles in regulating hepatic lipid metabolism, inhibiting hepatic inflammation, controlling hepatic fibrosis and mediating hepatocellular carcinoma in ALD. However, underlying molecular mechanisms are complex and remain incompletely understood. The aim of this review was to highlight the latest advances in understanding of SIRT1 regulatory mechanisms in ALD and discuss their unique potential role as novel therapeutic target for ALD treatment.

Keywords: Alcoholic liver disease, SIRT1, Inflammation, Fibrosis, Hepatocellular carcinoma