1. Department of Oncology, The Affiliated Hospital of Southwest Medical University, Sichuan, Luzhou, 644000, China. 2. Department of Cardiovascular Medicine, The Affiliated Hospital of Southwest Medical University, Sichuan, Luzhou, China. 3. Department of Bone and Joint, The Affiliated Hospital of Southwest Medical University, Luzhou, China. 4. Department of Gastrointestinal Surgery, The Affiliated Hospital of Southwest Medical University, Sichuan, Luzhou, China. 5. Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, China. 6. Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510000, China. 7. Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, China. †These authors contributed equally.
✉ Corresponding authors: Yuhao Luo, The Affiliated Hospital of Southwest Medical University, Sichuan, China. Phone number: 86-15183038114; E-mail: luoyuhao1992edu.cn. Li Xiang, The Affiliated Hospital of Southwest Medical University, Sichuan, China. Phone number: 86-13882728599; E-mail: xl790927com.More
Citation:
Li X, Luo J, Mou K, Peng L, Zhou H, Lei Y, Wang H, Zhao Z, Wang J, Wu J, Wan R, Lin S, Xiang L, Luo Y. SDPR Inhibits TGF-β Induced Cancer Metastasis Through Fatty Acid Oxidation Regulation in Gastric Cancer. Int J Biol Sci 2023; 19(10):2999-3014. doi:10.7150/ijbs.83012. https://www.ijbs.com/v19p2999.htm
Our previous studies have confirmed that transforming growth factor-β (TGF-β) plays an important role in tumor metastasis, and the serum deprivation protein response (SDPR) is a potential downstream target of TGF-β. However, the role and mechanism of SDPR in gastric cancer are still unclear. We performed gene microarray, bioinformation analysis, combined with in vivo and in vitro experimental verification, we identified that SDPR is significantly downregulated in gastric cancer, and participates in TGF-β-mediated tumour metastasis. Mechanically, SDPR interacts with extracellular signal-regulated kinase (ERK) and inhibits fatty acid metabolism key gene Carnitine palmitoyl transferase 1A (CPT1A) at transcriptional level by supressing ERK/PPAR pathway. Our findings suggest that the TGF-β/SDPR/CPT1A axis play an important role in the fatty acid oxidation of gastric cancer, and provides a new insight into the crosstalk of tumour microenvironments and metabolism reprogramming and suggest that strategies to intervene the fatty acid metabolism may therapy gastric cancer metastasis.
Keywords: TGF-β, SDPR, CPT1A, fatty acid oxidation, gastric cancer
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APA
Li, X., Luo, J., Mou, K., Peng, L., Zhou, H., Lei, Y., Wang, H., Zhao, Z., Wang, J., Wu, J., Wan, R., Lin, S., Xiang, L., Luo, Y. (2023). SDPR Inhibits TGF-β Induced Cancer Metastasis Through Fatty Acid Oxidation Regulation in Gastric Cancer. International Journal of Biological Sciences, 19(10), 2999-3014. https://doi.org/10.7150/ijbs.83012.
Li X, Luo J, Mou K, Peng L, Zhou H, Lei Y, Wang H, Zhao Z, Wang J, Wu J, Wan R, Lin S, Xiang L, Luo Y. SDPR Inhibits TGF-β Induced Cancer Metastasis Through Fatty Acid Oxidation Regulation in Gastric Cancer. Int J Biol Sci 2023; 19(10):2999-3014. doi:10.7150/ijbs.83012. https://www.ijbs.com/v19p2999.htm
CSE
Li X, Luo J, Mou K, Peng L, Zhou H, Lei Y, Wang H, Zhao Z, Wang J, Wu J, Wan R, Lin S, Xiang L, Luo Y. 2023. SDPR Inhibits TGF-β Induced Cancer Metastasis Through Fatty Acid Oxidation Regulation in Gastric Cancer. Int J Biol Sci. 19(10):2999-3014.
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