1. Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research and Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. 2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China. 3. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100700, China. # These authors contributed equally to this work.
Liang R, Cheng A, Lu S, Zhang X, Ren M, Lin J, Wu Y, Zhang W, Luan X. Seleno-amino Acid Metabolism Reshapes the Tumor Microenvironment: from Cytotoxicity to Immunotherapy. Int J Biol Sci 2024; 20(7):2779-2789. doi:10.7150/ijbs.95484. https://www.ijbs.com/v20p2779.htm
Selenium (Se) is an essential trace element for biological processes. Seleno-amino acids (Se-AAs), known as the organic forms of Se, and their metabolic reprogramming have been increasingly recognized to regulate antioxidant defense, enzyme activity, and tumorigenesis. Therefore, there is emerging interest in exploring the potential application of Se-AAs in antitumor therapy. In addition to playing a vital role in inhibiting tumor growth, accumulating evidence has revealed that Se-AA metabolism could reshape the tumor microenvironment (TME) and enhance immunotherapy responses. This review presents a comprehensive overview of the current progress in multifunctional Se-AAs for antitumor treatment, with a particular emphasis on elucidating the crosstalk between Se-AA metabolism and various cell types in the TME, including tumor cells, T cells, macrophages, and natural killer cells. Furthermore, novel applications integrating Se-AAs are also discussed alongside prospects to provide new insights into this emerging field.
Liang, R., Cheng, A., Lu, S., Zhang, X., Ren, M., Lin, J., Wu, Y., Zhang, W., Luan, X. (2024). Seleno-amino Acid Metabolism Reshapes the Tumor Microenvironment: from Cytotoxicity to Immunotherapy. International Journal of Biological Sciences, 20(7), 2779-2789. https://doi.org/10.7150/ijbs.95484.
ACS
Liang, R.; Cheng, A.; Lu, S.; Zhang, X.; Ren, M.; Lin, J.; Wu, Y.; Zhang, W.; Luan, X. Seleno-amino Acid Metabolism Reshapes the Tumor Microenvironment: from Cytotoxicity to Immunotherapy. Int. J. Biol. Sci. 2024, 20 (7), 2779-2789. DOI: 10.7150/ijbs.95484.
NLM
Liang R, Cheng A, Lu S, Zhang X, Ren M, Lin J, Wu Y, Zhang W, Luan X. Seleno-amino Acid Metabolism Reshapes the Tumor Microenvironment: from Cytotoxicity to Immunotherapy. Int J Biol Sci 2024; 20(7):2779-2789. doi:10.7150/ijbs.95484. https://www.ijbs.com/v20p2779.htm
CSE
Liang R, Cheng A, Lu S, Zhang X, Ren M, Lin J, Wu Y, Zhang W, Luan X. 2024. Seleno-amino Acid Metabolism Reshapes the Tumor Microenvironment: from Cytotoxicity to Immunotherapy. Int J Biol Sci. 20(7):2779-2789.
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