International Journal of Biological Sciences

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Volume 10 (10); 2014

Research Paper

Cationicity-Enhanced Analogues of the Antimicrobial Peptides, AcrAP1 and AcrAP2, from the Venom of the Scorpion, Androctonus crassicauda, Display Potent Growth Modulation Effects on Human Cancer Cell Lines
Qiang Du, Xiaojuan Hou, Lilin Ge, Renjie Li, Mei Zhou, Hui Wang, Lei Wang, Minjie Wei, Tianbao Chen, Chris Shaw
Int. J. Biol. Sci. 2014; 10(10): 1097-1107. doi:10.7150/ijbs.9859
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Dexmedetomidine-induced Contraction Involves Phosphorylation of Caldesmon by JNK in Endothelium-denuded Rat Aortas
Jiseok Baik, Seong-Ho Ok, Hyunhoo Cho, Jongsun Yu, Woochan Kim, In-Koo Nam, Mun-Jeoung Choi, Heon-Keun Lee, Ju-Tae Sohn
Int. J. Biol. Sci. 2014; 10(10): 1108-1115. doi:10.7150/ijbs.9797
[Abstract] [Full text] [PDF] [PubMed] [PMC]


The Steroid Receptor Coactivator-3 Is Required for Developing Neuroendocrine Tumor in the Mouse Prostate
Jean Ching-Yi Tien, Lan Liao, Yonghong Liu, Zhaoliang Liu, Dong-Kee Lee, Fen Wang, Jianming Xu
Int. J. Biol. Sci. 2014; 10(10): 1116-1127. doi:10.7150/ijbs.10236
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Defect in MAPK Signaling As a Cause for Monogenic Obesity Caused By Inactivating Mutations in the Melanocortin-4 Receptor Gene
Shan He, Ya-Xiong Tao
Int. J. Biol. Sci. 2014; 10(10): 1128-1137. doi:10.7150/ijbs.10359
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Interaction between HIV-1 Tat and DNA-PKcs modulates HIV transcription and class switch recombination
Shi-Meng Zhang, He Zhang, Tian-Yi Yang, Tian-Yi Ying, Pei-Xiang Yang, Xiao-Dan Liu, Sheng-Jian Tang, Ping-Kun Zhou
Int. J. Biol. Sci. 2014; 10(10): 1138-1149. doi:10.7150/ijbs.10366
[Abstract] [Full text] [PDF] [PubMed] [PMC]


The Insect Ecdysone Receptor is a Good Potential Target for RNAi-based Pest Control
Rong Yu, Xinping Xu, Yongkang Liang, Honggang Tian, Zhanqing Pan, Shouheng Jin, Na Wang, Wenqing Zhang
Int. J. Biol. Sci. 2014; 10(10): 1171-1180. doi:10.7150/ijbs.9598
[Abstract] [Full text] [PDF] [PubMed] [PMC]


The Viral Oncoprotein HBx of Hepatitis B virus Promotes the Growth of Hepatocellular Carcinoma through Cooperating with the Cellular Oncoprotein RMP
Qi Wang, Yi Xu, Wei Zhou, Lei Zhong, Zengqing Wen, Huijun Yu, Shaomu Chen, Jian Shen, Han Chen, Qinying She, Jingting Jiang, Jingcheng Miao, Wenxiang Wei
Int. J. Biol. Sci. 2014; 10(10): 1181-1192. doi:10.7150/ijbs.10275
[Abstract] [Full text] [PDF] [PubMed] [PMC]


SIRT1 Deacetylates TopBP1 and Modulates Intra-S-Phase Checkpoint and DNA Replication Origin Firing
Rui-Hong Wang, Tyler J. Lahusen, Qiang Chen, Xiaoling Xu, Lisa M. Miller Jenkins, Elisabetta Leo, Haiqing Fu, Mirit Aladjem, Yves Pommier, Ettore Appella, Chu-Xia Deng
Int. J. Biol. Sci. 2014; 10(10): 1193-1202. doi:10.7150/ijbs.11066
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review

Small Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer Therapeutics
Bing-Jia Chen, Yan-Ling Wu, Yoshimasa Tanaka, Wen Zhang
Int. J. Biol. Sci. 2014; 10(10): 1084-1096. doi:10.7150/ijbs.10190
[Abstract] [Full text] [PDF] [PubMed] [PMC]


RNA Interference (RNAi) Induced Gene Silencing: A Promising Approach of Hi-Tech Plant Breeding
Adnan Younis, Muhammad Irfan Siddique, Chang-Kil Kim, Ki-Byung Lim
Int. J. Biol. Sci. 2014; 10(10): 1150-1158. doi:10.7150/ijbs.10452
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Flavonoids and Melanins: A Common Strategy across Two Kingdoms
Giorgia Carletti, Giuseppe Nervo, Luigi Cattivelli
Int. J. Biol. Sci. 2014; 10(10): 1159-1170. doi:10.7150/ijbs.9672
[Abstract] [Full text] [PDF] [PubMed] [PMC]