International Journal of Biological Sciences

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Volume 11 (4); 2015

Research Paper

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PKD1 Mono-Allelic Knockout Is Sufficient to Trigger Renal Cystogenesis in a Mini-Pig Model
Jin He, Qiuyan Li, Suyun Fang, Ying Guo, Tongxin Liu, Jianhua Ye, Zhengquan Yu, Ran Zhang, Yaofeng Zhao, Xiaoxiang Hu, Xueyuan Bai, Xiangmei Chen, Ning Li
Int. J. Biol. Sci. 2015; 11(4): 361-369. doi:10.7150/ijbs.10858
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Caveolin-1 is a Modulator of Fibroblast Activation and a Potential Biomarker for Gastric Cancer
Xiao-Jun Shen, Hao Zhang, Gu-Sheng Tang, Xu-Dong Wang, Rui Zheng, Yang Wang, Yan Zhu, Xu-Chao Xue, Jian-Wei Bi
Int. J. Biol. Sci. 2015; 11(4): 370-379. doi:10.7150/ijbs.10666
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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MicroRNA-23a Participates in Estrogen Deficiency Induced Gap Junction Remodeling of Rats by Targeting GJA1
Ning Wang, Lu-Yao Sun, Shou-Chen Zhang, Ran Wei, Fang Xie, Jing Liu, Yan Yan, Ming-Jing Duan, Lin-Lin Sun, Ying-Hui Sun, Hui-Fang Niu, Rong Zhang, Jing Ai
Int. J. Biol. Sci. 2015; 11(4): 390-403. doi:10.7150/ijbs.10930
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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MEK Inhibitor PD-0325901 Overcomes Resistance to CK2 Inhibitor CX-4945 and Exhibits Anti-Tumor Activity in Head and Neck Cancer
Yansong Bian, Jiawei Han, Vishnu Kannabiran, Suresh Mohan, Hui Cheng, Jay Friedman, Luo Zhang, Carter VanWaes, Zhong Chen
Int. J. Biol. Sci. 2015; 11(4): 411-422. doi:10.7150/ijbs.10745
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Biased Signaling in Naturally Occurring Mutations in Human Melanocortin-3 Receptor Gene
Fan Yang, Hui Huang, Ya-Xiong Tao
Int. J. Biol. Sci. 2015; 11(4): 423-433. doi:10.7150/ijbs.11032
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Tetratricopeptide Repeat Domain 9A Negatively Regulates Estrogen Receptor Alpha Activity
Smeeta Shrestha, Yang Sun, Thomas Lufkin, Petra Kraus, Yuzuan Or, Yenni A. Garcia, Naihsuan Guy, Paola Ramos, Marc B. Cox, Fiona Tay, Valerie CL Lin
Int. J. Biol. Sci. 2015; 11(4): 434-447. doi:10.7150/ijbs.9311
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Hints for Metal-Preference Protein Sequence Determinants: Different Metal Binding Features of the Five Tetrahymena thermophila Metallothioneins
Anna Espart, Maribel Marín, Selene Gil-Moreno, Òscar Palacios, Francisco Amaro, Ana Martín-González, Juan C. Gutiérrez, Mercè Capdevila, Sílvia Atrian
Int. J. Biol. Sci. 2015; 11(4): 456-471. doi:10.7150/ijbs.11060
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Stem Cell Transplantation Upregulates Sirt1 and Antioxidant Expression, Ameliorating Fatty Liver in Type 2 Diabetic Mice
Ming Li, Kequan Guo, Luca Vanella, Shigeru Taketani, Yasushi Adachi, Susumu Ikehara
Int. J. Biol. Sci. 2015; 11(4): 472-481. doi:10.7150/ijbs.10809
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Activation of TLR3 Induces Osteogenic Responses in Human Aortic Valve Interstitial Cells through the NF-κB and ERK1/2 Pathways
Qiong Zhan, Rui Song, Qingchun Zeng, Qingzhou Yao, Lihua Ao, Dingli Xu, David A. Fullerton, Xianzhong Meng
Int. J. Biol. Sci. 2015; 11(4): 482-493. doi:10.7150/ijbs.10905
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Short Research Communication

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Identification of Novel Focal Adhesion Kinase Substrates: Role for FAK in NFκB Signaling
Sheila Figel Dwyer, Lingqiu Gao, Irwin H. Gelman
Int. J. Biol. Sci. 2015; 11(4): 404-410. doi:10.7150/ijbs.10273
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review

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Lethal (2) Giant Larvae: An Indispensable Regulator of Cell Polarity and Cancer Development
Fang Cao, Yi Miao, Kedong Xu, Peijun Liu
Int. J. Biol. Sci. 2015; 11(4): 380-389. doi:10.7150/ijbs.11243
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Signal Transducer and Activator of Transcription 4 in Liver Diseases
Yan Wang, Aijuan Qu, Hua Wang
Int. J. Biol. Sci. 2015; 11(4): 448-455. doi:10.7150/ijbs.11164
[Abstract] [Full text] [PDF] [PubMed] [PMC]