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Int J Biol Sci 2009; 5(7):758-762. doi:10.7150/ijbs.5.758 This issue Cite

Review

Physiological and Oncogenic Aurora-A Pathway

Toshiaki SAEKI¹, Mutsuko OUCHI², Toru OUCHI^{2 ✉}

1. Department of Breast Oncology, Saitama Medical School, Saitama, JAPAN
2. NUHS, Systems Biology Program, Pritzker School of Medicine, University of Chicago, Evanston, IL 60201, USA

✉ Correspondence to: Toru Ouchi, University of Chicago, 1001 University Place, Evanston, IL 60201. Tel: 224.364.7687; Fax: 224.364.7402; Email: touchiuchicago.edu

Abstract

Aurora family of protein kinases have emerged as crucial factors of, not only mitosis and cytokinesis, but also human carcinogenesis. Among these family members is Aurora-A that is frequently overexpressed in varieties of human cancer. Both in vitro and in vivo studies demonstrated that Aurora-A induces tumorigenesis through genome instability. These studies have further shown that cell signaling cross-talk between Aurora-A and other cellular proteins are essential for fully-transformed phenotypes. This review summarizes recent progress of Aurora-A-associated carcinogenesis.

Keywords: Aurora-A, Plk1, mTOR, Cell Cycle, Checkpoint, Genome Instability, Phosphorylation

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