Int J Biol Sci 2011; 7(5):575-587. doi:10.7150/ijbs.7.575


Mammalian Sirtuins and Energy Metabolism

Xiaoling Li, Nevzat Kazgan

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
Li X, Kazgan N. Mammalian Sirtuins and Energy Metabolism. Int J Biol Sci 2011; 7(5):575-587. doi:10.7150/ijbs.7.575. Available from

File import instruction


Sirtuins are highly conserved NAD+-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies. The seven mammalian sirtuins, SIRT1 to SIRT7, have emerged as key metabolic sensors that directly link environmental signals to mammalian metabolic homeostasis and stress response. Recent studies have shed light on the critical roles of sirtuins in mammalian energy metabolism in response to nutrient signals. This review focuses on the involvement of two nuclear sirtuins, SIRT1 and SIRT6, and three mitochondrial sirtuins, SIRT3, SIRT4, and SIRT5, in regulation of diverse metabolic processes.

Keywords: sirtuins, energy metabolism, aging, nutrients