Reverse the Resistance to PARP Inhibitors

Kim, Yevgeniy; Kim, Aleksei; Sharip, Ainur; Sharip, Aigul; Jiang, Juhong; Yang, Qing; Xie, Yingqiu

doi:10.7150/ijbs.17240

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Int J Biol Sci 2017; 13(2):198-208. doi:10.7150/ijbs.17240 This issue Cite

Review

Reverse the Resistance to PARP Inhibitors

Yevgeniy Kim^1*, Aleksei Kim^1*, Ainur Sharip^1*, Aigul Sharip^1*, Juhong Jiang², Qing Yang¹, Yingqiu Xie^1✉

1. Department of Biology, Nazarbayev University, School of Science and Technology, Astana, 010000, Republic of Kazakhstan;
2. Department of Pathology, the First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
* Co-first authors.

Citation:

Kim Y, Kim A, Sharip A, Sharip A, Jiang J, Yang Q, Xie Y. Reverse the Resistance to PARP Inhibitors. Int J Biol Sci 2017; 13(2):198-208. doi:10.7150/ijbs.17240. https://www.ijbs.com/v13p0198.htm

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Abstract

One of the DNA repair machineries is activated by Poly (ADP-ribose) Polymerase (PARP) enzyme. Particularly, this enzyme is involved in repair of damages to single-strand DNA, thus decreasing the chances of generating double-strand breaks in the genome. Therefore, the concept to block PARP enzymes by PARP inhibitor (PARPi) was appreciated in cancer treatment. PARPi has been designed and tested for many years and became a potential supplement for the conventional chemotherapy. However, increasing evidence indicates the appearance of the resistance to this treatment. Specifically, cancer cells may acquire new mutations or events that overcome the positive effect of these drugs. This paper describes several molecular mechanisms of PARPi resistance which were reported most recently, and summarizes some strategies to reverse this type of drug resistance.

Keywords: PARP, PARP inhibitor, drug resistance, DNA repair

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APA

Kim, Y., Kim, A., Sharip, A., Sharip, A., Jiang, J., Yang, Q., Xie, Y. (2017). Reverse the Resistance to PARP Inhibitors. International Journal of Biological Sciences, 13(2), 198-208. https://doi.org/10.7150/ijbs.17240.

ACS

Kim, Y.; Kim, A.; Sharip, A.; Sharip, A.; Jiang, J.; Yang, Q.; Xie, Y. Reverse the Resistance to PARP Inhibitors. Int. J. Biol. Sci. 2017, 13 (2), 198-208. DOI: 10.7150/ijbs.17240.

NLM

Kim Y, Kim A, Sharip A, Sharip A, Jiang J, Yang Q, Xie Y. Reverse the Resistance to PARP Inhibitors. Int J Biol Sci 2017; 13(2):198-208. doi:10.7150/ijbs.17240. https://www.ijbs.com/v13p0198.htm

CSE

Kim Y, Kim A, Sharip A, Sharip A, Jiang J, Yang Q, Xie Y. 2017. Reverse the Resistance to PARP Inhibitors. Int J Biol Sci. 13(2):198-208.

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