Int J Biol Sci 2019; 15(6):1261-1275. doi:10.7150/ijbs.30741

Review

Recent Advances in Studies of Molecular Hydrogen against Sepsis

Peng Qiu1, Yang Liu2, Jin Zhang1✉

1. Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, China
2. Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China

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Citation:
Qiu P, Liu Y, Zhang J. Recent Advances in Studies of Molecular Hydrogen against Sepsis. Int J Biol Sci 2019; 15(6):1261-1275. doi:10.7150/ijbs.30741. Available from http://www.ijbs.com/v15p1261.htm

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Abstract

Sepsis is a syndrome comprised of a series of life-threatening organ dysfunctions caused by a maladjusted body response to infection with no effective treatment. Molecular hydrogen is a new type of antioxidant with strong free radical scavenging ability, which has been demonstrated to be effective for treating various diseases, such as infection, trauma, poisoning, organ ischemia-reperfusion, metabolic diseases, and tumors. Molecular hydrogen exerts multiple biological effects involving anti-inflammation, anti-oxidation, anti-apoptosis, anti-shock, and autophagy regulation, which may attenuate the organ and barrier damage caused by sepsis. However, the underlying molecular mechanisms remain elusive, but are likely related to the signaling pathways involved. This review focuses on the research progress and potential mechanisms of molecular hydrogen against sepsis to provide a theoretical basis for clinical treatment.

Keywords: molecular hydrogen, sepsis, oxidative stress, apoptosis, shock, autophagy