Int J Biol Sci 2019; 15(10):2128-2138. doi:10.7150/ijbs.35460

Review

Radiation-induced heart disease: a review of classification, mechanism and prevention

Heru Wang1,2, Jinlong Wei1, Qingshuang Zheng2, Lingbin Meng3, Ying Xin4, Xia Yin2✉, Xin Jiang1✉

1. Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, 130021, China
2. Department of Cardiology, The First Hospital of Jilin University, Changchun, 130021, China
3. Department of Internal Medicine, Florida Hospital, Orlando, FL 32804,USA
4. Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, China

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Citation:
Wang H, Wei J, Zheng Q, Meng L, Xin Y, Yin X, Jiang X. Radiation-induced heart disease: a review of classification, mechanism and prevention. Int J Biol Sci 2019; 15(10):2128-2138. doi:10.7150/ijbs.35460. Available from http://www.ijbs.com/v15p2128.htm

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Abstract

With the increasing incidence of thoracic tumors, radiation therapy (RT) has become an important component of comprehensive treatment. RT improves survival in many cancers, but it involves some inevitable complications. Radiation-induced heart disease (RIHD) is one of the most serious complications. RIHD comprises a spectrum of heart disease including cardiomyopathy, pericarditis, coronary artery disease, valvular heart disease and conduction system abnormalities. There are numerous clinical manifestations of RIHD, such as chest pain, palpitation, and dyspnea, even without obvious symptoms. Based on previous studies, the pathogenesis of RIHD is related to the production and effects of various cytokines caused by endothelial injury, inflammatory response, and oxidative stress (OS). Therefore, it is of great importance for clinicians to identify the mechanism and propose interventions for the prevention of RIHD.

Keywords: Radiation-induced heart disease, inflammation, oxidative stress, statins, ACE inhibitors.