Tanshinone IIA attenuates demyelination and promotes remyelination in<i> A. cantonensis</i>-infected BALB/c mice

Feng, Ying; Feng, Feng; Zheng, Cunjing; Zhou, Zongpu; Jiang, Meihua; Liu, Zhen; Xie, Fukang; Sun, Xi; Wu, Zhongdao

doi:10.7150/ijbs.35266

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Int J Biol Sci 2019; 15(10):2211-2223. doi:10.7150/ijbs.35266 This issue Cite

Research Paper

Tanshinone IIA attenuates demyelination and promotes remyelination in A. cantonensis-infected BALB/c mice

Ying Feng¹, Feng Feng⁴, Cunjing Zheng⁵, Zongpu Zhou¹, Meihua Jiang⁶, Zhen Liu⁷, Fukang Xie⁵, Xi Sun^2,3✉, Zhongdao Wu^2,3✉

1. Medical School of South China University of Technology, Guangzhou, China
2. Parasitology Department of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
3. Key Laboratory of Tropical Disease Control (SYSU), Ministry of Education, Guangzhou, China
4. The Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China
5. Histology and Embryology Department of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
6. Anatomy Department of Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
7. Guangzhou First People's Hospital, Guangzhou, China

Citation:

Feng Y, Feng F, Zheng C, Zhou Z, Jiang M, Liu Z, Xie F, Sun X, Wu Z. Tanshinone IIA attenuates demyelination and promotes remyelination in A. cantonensis-infected BALB/c mice. Int J Biol Sci 2019; 15(10):2211-2223. doi:10.7150/ijbs.35266. https://www.ijbs.com/v15p2211.htm

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Abstract

Background: Angiostrongylus cantonensis infection can cause demyelination in the central nervous system, and there is no effective treatment. Methods: We used dexamethasone, Tanshinone IIA (TSIIA) and Cryptotanshinone(Two traditional Chinese medicine monomers) in combination with albendazole (AB, a standard anti-helminthic compound) to observe their therapeutic effect on demyelination in A. cantonensis-infected mice. Luxol fast blue staining and electron microscope of myelin sheath, Oligodendrocyte (OL) number and myelin basic protein (MBP) expression in brain was detected in above groups. Results: TSIIA+AB facilitated OL proliferation and significantly increased both myelin sheath thickness and the population of small-diameter axons. In addition, TSIIA treatment inhibited the expression of inflammation-related factors (interleukin [IL]-6, IL-1β, tumor necrosis factor [TNF]-α, inducible nitric oxide synthase [iNOS]) rather than inhibiting eosinophil infiltration in brain. TSIIA also decreased microglial activation and shifted their phenotype from M1 to M2. Conclusions: Taken together, these results provide evidence that TSIIA combined with AB may be an effective treatment for demyelination caused by A. cantonensis infection and other demyelinating diseases.

Keywords: Tanshinone IIA, demyelination, remyelination, microglia polarization, A. cantonensis

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APA

Feng, Y., Feng, F., Zheng, C., Zhou, Z., Jiang, M., Liu, Z., Xie, F., Sun, X., Wu, Z. (2019). Tanshinone IIA attenuates demyelination and promotes remyelination in A. cantonensis-infected BALB/c mice. International Journal of Biological Sciences, 15(10), 2211-2223. https://doi.org/10.7150/ijbs.35266.

ACS

Feng, Y.; Feng, F.; Zheng, C.; Zhou, Z.; Jiang, M.; Liu, Z.; Xie, F.; Sun, X.; Wu, Z. Tanshinone IIA attenuates demyelination and promotes remyelination in A. cantonensis-infected BALB/c mice. Int. J. Biol. Sci. 2019, 15 (10), 2211-2223. DOI: 10.7150/ijbs.35266.

NLM

CSE

Feng Y, Feng F, Zheng C, Zhou Z, Jiang M, Liu Z, Xie F, Sun X, Wu Z. 2019. Tanshinone IIA attenuates demyelination and promotes remyelination in A. cantonensis-infected BALB/c mice. Int J Biol Sci. 15(10):2211-2223.

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