Andrographolide Protects Against Adverse Cardiac Remodeling After Myocardial Infarction through Enhancing Nrf2 Signaling Pathway

Xie, Saiyang; Deng, Wei; Chen, Jiaojiao; Wu, Qing-Qing; Li, Hongjian; Wang, Juan; Wei, Li; Liu, Chen; Duan, Mingxia; Cai, Zhulan; Xie, Qingwen; Hu, Tongtong; Zeng, Xiaofeng; Tang, Qizhu

doi:10.7150/ijbs.37269



Theranostics

International Journal of Medical Sciences

Nanotheranostics

Journal of Cancer

Journal of Genomics

Global reach, higher impact

Full Text | PDF

Int J Biol Sci 2020; 16(1):12-26. doi:10.7150/ijbs.37269 This issue Cite

Research Paper

Andrographolide Protects Against Adverse Cardiac Remodeling After Myocardial Infarction through Enhancing Nrf2 Signaling Pathway

Saiyang Xie^1,2,3, Wei Deng^1,2,3✉, Jiaojiao Chen⁴, Qing-Qing Wu^1,2,3, Hongjian Li⁵, Juan Wang⁵, Li Wei⁴, Chen Liu^1,2,3, Mingxia Duan^1,2,3, Zhulan Cai^1,2,3, Qingwen Xie^1,2,3, Tongtong Hu^1,2,3, Xiaofeng Zeng^1,2,3, Qizhu Tang^1,2,3

1. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, RP China
2. Cardiovascular Research Institute of Wuhan University, Wuhan 430060, RP China
3. Hubei Key Laboratory of Cardiology, Wuhan 430060, RP China
4. Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan 430060, RP China
5. Department of Cardiology, The Fifth Affiliated Hospital of Xinjiang Medical University, Ürümqi, China

Citation:

Xie S, Deng W, Chen J, Wu QQ, Li H, Wang J, Wei L, Liu C, Duan M, Cai Z, Xie Q, Hu T, Zeng X, Tang Q. Andrographolide Protects Against Adverse Cardiac Remodeling After Myocardial Infarction through Enhancing Nrf2 Signaling Pathway. Int J Biol Sci 2020; 16(1):12-26. doi:10.7150/ijbs.37269. https://www.ijbs.com/v16p0012.htm

Other styles

Abstract

Adverse cardiac remodeling after myocardial infarction (MI) is associated with extremely high mortality rates worldwide. Although optimized medical therapy, Preservation of lusitropic and inotropic function and protection against adverse remodeling in ventricular structure remain relatively frequent. This study demonstrated that Andrographolide (Andr) significantly ameliorated adverse cardiac remodeling induced by myocardial infarction and improves contractile function in mice with LAD ligation compared with the control group. Briefly, Andr markedly attenuated cardiac fibrosis and relieved inflammation after myocardial infarction. Specifically, Andr significantly blocked oxidative stress and the nuclear translocation of p-P65 following myocardial infarction. At the mechanistic level, antioxidant effect of Andr was achieved through strengthening antioxidative stress capacity and attributed to the activation of Nrf2/HO-1 Signaling. Consistently, H9C2 administrated with Andr showed a decreased oxidative stress caused by hypoxia precondition, but treatment with specific Nrf2 inhibitor (ML385) or the silence of Nrf2 blunted the activation of Nrf2/HO-1 Signaling and removed the protective effects of Andr in vitro. Thus, we suggest that Andr alleviates adverse cardiac remodeling following myocardial infarction through enhancing Nrf2 signaling pathway.

Keywords: Andrographolide, Nrf2, cardiac remodeling

Citation styles

APA

Xie, S., Deng, W., Chen, J., Wu, Q.Q., Li, H., Wang, J., Wei, L., Liu, C., Duan, M., Cai, Z., Xie, Q., Hu, T., Zeng, X., Tang, Q. (2020). Andrographolide Protects Against Adverse Cardiac Remodeling After Myocardial Infarction through Enhancing Nrf2 Signaling Pathway. International Journal of Biological Sciences, 16(1), 12-26. https://doi.org/10.7150/ijbs.37269.

ACS

Xie, S.; Deng, W.; Chen, J.; Wu, Q.Q.; Li, H.; Wang, J.; Wei, L.; Liu, C.; Duan, M.; Cai, Z.; Xie, Q.; Hu, T.; Zeng, X.; Tang, Q. Andrographolide Protects Against Adverse Cardiac Remodeling After Myocardial Infarction through Enhancing Nrf2 Signaling Pathway. Int. J. Biol. Sci. 2020, 16 (1), 12-26. DOI: 10.7150/ijbs.37269.

NLM

CSE

Xie S, Deng W, Chen J, Wu QQ, Li H, Wang J, Wei L, Liu C, Duan M, Cai Z, Xie Q, Hu T, Zeng X, Tang Q. 2020. Andrographolide Protects Against Adverse Cardiac Remodeling After Myocardial Infarction through Enhancing Nrf2 Signaling Pathway. Int J Biol Sci. 16(1):12-26.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.