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Int J Biol Sci 2020; 16(2):309-319. doi:10.7150/ijbs.37162 This issue Cite

Research Paper

Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling

Lin Zhou1,2*, Guoju Hong1,3*, Shangfu Li1,4*, Qian Liu1,5, Fangming Song1,5, Jinmin Zhao5, Jinbo Yuan1, Jennifer Tickner1, Jiake Xu1✉

1. School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, 6009, Australia
2. Department of Endocrinology, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510700, China.
3. Orthopedic Department, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
4. Department of Spine Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou Guangdong, 510630, P. R. China.
5. Research Centre for Regenerative Medicine and Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Guangxi, 530021, China
*Authors equally contributed to this work.

✉ Corresponding author: Jiake Xu, E-mail: jiake.xuedu.au

Citation:
Zhou L, Hong G, Li S, Liu Q, Song F, Zhao J, Yuan J, Tickner J, Xu J. Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling. Int J Biol Sci 2020; 16(2):309-319. doi:10.7150/ijbs.37162. https://www.ijbs.com/v16p0309.htm
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Abstract

Graphic abstract

Osteoporosis is a disease characterized by abnormally increased formation and function of osteoclasts. Anti-RANKL treatment using natural medicine is a potential therapy for osteoporosis. Here, we studied the effect of fangchinoline, which is extracted from the root of Stephania tetrandra S. Moore, on osteoclast formation and function. We found that fangchinoline inhibited osteoclastogenesis at doses of 0.5 and 1 µM. In addition, we also examined the mechanism of the inhibitory effect of fangchinoline on osteoclasts. We found that fangchinoline down regulated NFATc1 activity and expression. However, fangchinoline did not affect IκBα degradation and MAPK pathways. In addition, we also found that fangchinoline could protect against bone loss in OVX mice. Taken together, fangchinoline may be a potential compound for osteoporosis.

Keywords: fangchinoline, RANKL, osteoclast, NF-κB, NFATc1, MAPK

Citation styles

APA
Zhou, L., Hong, G., Li, S., Liu, Q., Song, F., Zhao, J., Yuan, J., Tickner, J., Xu, J. (2020). Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling. International Journal of Biological Sciences, 16(2), 309-319. https://doi.org/10.7150/ijbs.37162.

ACS
Zhou, L.; Hong, G.; Li, S.; Liu, Q.; Song, F.; Zhao, J.; Yuan, J.; Tickner, J.; Xu, J. Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling. Int. J. Biol. Sci. 2020, 16 (2), 309-319. DOI: 10.7150/ijbs.37162.

NLM
Zhou L, Hong G, Li S, Liu Q, Song F, Zhao J, Yuan J, Tickner J, Xu J. Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling. Int J Biol Sci 2020; 16(2):309-319. doi:10.7150/ijbs.37162. https://www.ijbs.com/v16p0309.htm

CSE
Zhou L, Hong G, Li S, Liu Q, Song F, Zhao J, Yuan J, Tickner J, Xu J. 2020. Fangchinoline protects against bone loss in OVX mice via inhibiting osteoclast formation, bone resorption and RANKL-induced signaling. Int J Biol Sci. 16(2):309-319.

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