Int J Biol Sci 2020; 16(11):1767-1773. doi:10.7150/ijbs.41105

Review

B7-H3, a checkpoint molecule, as a target for cancer immunotherapy

Shuo Yang1,2,3, Wei Wei4✉, Qi Zhao1,2,3✉

1. Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau SPR, China.
2. Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SPR, China.
3. Biological Imaging & Stem Cell Core, Faculty of Health Sciences, University of Macau, Taipa, Macau SPR, China.
4. Guangdong Cord Blood Bank; Guangzhou Municipality Tianhe Nuoya Bio-engineering Co. Ltd, Guangzhou, China

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Citation:
Yang S, Wei W, Zhao Q. B7-H3, a checkpoint molecule, as a target for cancer immunotherapy. Int J Biol Sci 2020; 16(11):1767-1773. doi:10.7150/ijbs.41105. Available from http://www.ijbs.com/v16p1767.htm

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Abstract

B7-H3 (also known as CD276) is a newly found molecule of B7 family, which may be a promising target for cancer treatment. B7-H3 protein was demonstrated to be expressed in several kinds of tumor tissues including non-small-cell lung cancer (NSCLC) and prostate cancer. Its expression is highly associated with undesirable treatment outcomes and survival time, due to function of the immune checkpoint molecule. It was classified as either a co-stimulatory molecule for T cell activation or the nonimmunological role of regulating signaling pathways. Although there is still no agreed conclusion on the function of B7-H3, it may be a valuable target for cancer therapy. This review aims to provide a comprehensive, up-to-date summary of the advances in B7-H3 targeting approaches in cancer therapy. Although several challenges remain, B7-H3 offers a new therapeutic target with increased efficacy and less toxicity in future cancer treatment.

Keywords: B7-H3, CD276, cancer immunotherapy, antibody, immune checkpoint