Full Text | PDF

Share on tweeters Share on facebook Share on linkedin Share on googleplus

Int J Biol Sci 2020; 16(11):1989-2000. doi:10.7150/ijbs.43062 This issue Cite

Research Paper

Long noncoding RNA MYLK-AS1 promotes growth and invasion of hepatocellular carcinoma through the EGFR/HER2-ERK1/2 signaling pathway

Juan Liu1,2, Si-yuan Zhao3, Qiwei Jiang1, Yuanyuan Qu2, Xiaomei Huang2, Jundong Du4✉, Wanjun Sun2✉, Qinong Ye1✉

1. Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing 100850, China.
2. Department of Hematology, PLA Rocket Force Characteristic Medical Center, Beijing 100088, China.
3. Medical unit, 91638 Troops, PLA, Beijing 102202, China.
4. Department of Surgery, Hebei Yanda Hospital, Hebei 065201, China.

✉ Corresponding authors: Qinong Ye, Department of Medical Molecular Biology, Beijing Institute of Biotechnology, Beijing 100850, China. Phone: 8610-66931830; Fax: 8610-88271216; E-mail: yeqn66com; Wanjun Sun, Department of Hematology, PLA Rocke More

Citation:
Liu J, Zhao Sy, Jiang Q, Qu Y, Huang X, Du J, Sun W, Ye Q. Long noncoding RNA MYLK-AS1 promotes growth and invasion of hepatocellular carcinoma through the EGFR/HER2-ERK1/2 signaling pathway. Int J Biol Sci 2020; 16(11):1989-2000. doi:10.7150/ijbs.43062. https://www.ijbs.com/v16p1989.htm
Other styles

File import instruction

Abstract

Graphic abstract

The epidermal growth factor receptor (EGFR) family members EGFR and HER2 play pivotal roles in oncogenesis and tumor progression. Anticancer drugs targeting EGFR and HER2 have been developed. Long noncoding RNAs (lncRNAs) have been reported to regulate cancer development and progression through signaling pathways. However, lncRNAs that regulate EGFR and HER2 expression remain unknown. Here, we show that lncRNA myosin light chain kinase-antisense RNA 1 (MYLK-AS1) promotes EGFR and HER2 expression and activates their downstream signaling pathway. MYLK-AS1 increases hepatocellular carcinoma (HCC) cell proliferation, migration, and invasion in vitro. Consistently, MYLK-AS1 knockdown hinders tumor growth in vivo. Mechanistically, MYLK-AS1 enhances HCC cell proliferation, migration, and invasion through stimulating the EGFR/HER2-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway. In addition, MYLK-AS1 is overexpressed in HCC patients and negatively correlated with HCC prognosis. Thus, MYLK-AS1 is an upstream regulator of EGFR/HER2, and acts as an oncogene, suggesting an additional target for cancer therapeutics.

Keywords: LncRNA, MYLK-AS1, hepatocellular carcinoma, EGFR, HER2

Citation styles

APA
Liu, J., Zhao, S.y., Jiang, Q., Qu, Y., Huang, X., Du, J., Sun, W., Ye, Q. (2020). Long noncoding RNA MYLK-AS1 promotes growth and invasion of hepatocellular carcinoma through the EGFR/HER2-ERK1/2 signaling pathway. International Journal of Biological Sciences, 16(11), 1989-2000. https://doi.org/10.7150/ijbs.43062.

ACS
Liu, J.; Zhao, S.y.; Jiang, Q.; Qu, Y.; Huang, X.; Du, J.; Sun, W.; Ye, Q. Long noncoding RNA MYLK-AS1 promotes growth and invasion of hepatocellular carcinoma through the EGFR/HER2-ERK1/2 signaling pathway. Int. J. Biol. Sci. 2020, 16 (11), 1989-2000. DOI: 10.7150/ijbs.43062.

NLM
Liu J, Zhao Sy, Jiang Q, Qu Y, Huang X, Du J, Sun W, Ye Q. Long noncoding RNA MYLK-AS1 promotes growth and invasion of hepatocellular carcinoma through the EGFR/HER2-ERK1/2 signaling pathway. Int J Biol Sci 2020; 16(11):1989-2000. doi:10.7150/ijbs.43062. https://www.ijbs.com/v16p1989.htm

CSE
Liu J, Zhao Sy, Jiang Q, Qu Y, Huang X, Du J, Sun W, Ye Q. 2020. Long noncoding RNA MYLK-AS1 promotes growth and invasion of hepatocellular carcinoma through the EGFR/HER2-ERK1/2 signaling pathway. Int J Biol Sci. 16(11):1989-2000.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image

©2024 Ivyspring International Publisher. Terms of use