Int J Biol Sci 2020; 16(12):2104-2115. doi:10.7150/ijbs.44906

Research Paper

5-HT receptor agonist Valerenic Acid enhances the innate immunity signal and suppresses glioblastoma cell growth and invasion

Qingli Lu1, Yuan Ding2, Yang Li3,✉, Qingli Lu1,✉

1. Department of Dermatology and Venereology, Binhaiwan Central Hospital of Dongguan, Dongguan 523000, P.R. China.
2. Department of Dermatology and Venereology, People's Hospital of Xin jiang Uygur Autonomous Region, Urumqi 830000, P.R. China.
3. Department of Immunology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, P.R. China.

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Citation:
Lu Q, Ding Y, Li Y, Lu Q. 5-HT receptor agonist Valerenic Acid enhances the innate immunity signal and suppresses glioblastoma cell growth and invasion. Int J Biol Sci 2020; 16(12):2104-2115. doi:10.7150/ijbs.44906. Available from http://www.ijbs.com/v16p2104.htm

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Abstract

Glioblastoma multiform (GBM) continues to threaten people's lives due to the limited therapeutic strategies. As a new drug, Valerenic Acid suppresses the progression of GBM, however, the mechanism is largely unknown. Here, we found that Valerenic Acid can inhibit cell proliferation, migration and invasion of GBM cells by increasing innate immune signals such as enhancing ROS levels and activating the AMPK pathway. Inhibition of ROS by N-acetylcysteine (NAC) or attenuation of AMPK by Compound C could block Valerenic Acid-induced cell death. Additionally, the xenograft mouse model also confirmed that Valerenic Acid had anti-tumor effect. Together, our results provide compelling rational to develop Valerenic Acid as an anti-tumor agent against GBM patients.

Keywords: 5-HT receptor, Valerenic Acid, glioblastoma cell