Int J Biol Sci 2020; 16(14):2518-2526. doi:10.7150/ijbs.48330

Review

Immunoproteasome in IgA Nephropathy: State-of-Art and Future Perspectives

Ting Gan, Yang Li, Xu-jie Zhou, Hong Zhang

Renal Division, Peking University First Hospital; Peking University Institute of Nephrology; Key Laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, 100034, People's Republic of China; Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases, Chinese Academy of Medical Sciences.

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Citation:
Gan T, Li Y, Zhou Xj, Zhang H. Immunoproteasome in IgA Nephropathy: State-of-Art and Future Perspectives. Int J Biol Sci 2020; 16(14):2518-2526. doi:10.7150/ijbs.48330. Available from http://www.ijbs.com/v16p2518.htm

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Abstract

IgA nephropathy (IgAN) is a leading cause of chronic kidney disease and renal failure. The exact pathogenesis of IgAN is not well defined, but some genetic studies have led to a novel discovery that the immunoproteasome probably plays an important role in IgAN. The immunoproteasome is a proteasome variant that is expressed when cells are stressed or receive inflammatory signals. While immunoproteasome is suggested to be mainly involved in major histocompatibility complex-I (MHC-I) antigen presentation, recent studies indicate that it may assert broad functions in trafficking events that activate both innate and adaptive immunity. In this review, we first summarize new insights into its functions in immunity, and discuss how it underlies its associations with IgAN. We also highlight its potential as a therapeutic target for the future.

Keywords: IgA nephropathy, Glomerulonephritis, Immunoproteasome, Autoimmunity