Hydrogen Sulfide Plays an Important Role by Influencing NLRP3 inflammasome

Honggang Wang^1✉, Xingzhuo Shi², Mengyuan Qiu¹, Shuangyu Lv¹, Hong Zheng¹, Baohua Niu¹, Huiyang Liu¹

1. Institute of Biomedical Informatics, Bioinformatics Center, School of Basic Medical Sciences, Henan University, Kaifeng, Henan, 475000, China
2. School of Life Science, Henan University, Kaifeng, Henan, 475000, China

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Citation:
Wang H, Shi X, Qiu M, Lv S, Zheng H, Niu B, Liu H. Hydrogen Sulfide Plays an Important Role by Influencing NLRP3 inflammasome. Int J Biol Sci 2020; 16(14):2752-2760. doi:10.7150/ijbs.47595. Available from https://www.ijbs.com/v16p2752.htm

Abstract

Inflammasome is a complex composed of several proteins and an important part of the natural immune system. Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is composed of NLRP3, apoptosis associated speck like protein (ASC) and pro-caspase-1. It plays an important role in many diseases. Hydrogen sulfide (H₂S) is an important signaling molecule that regulates many physiological and pathological processes. Recent studies indicated that H₂S played anti-inflammatory and pro-inflammatory roles in many diseases through influencing NLRP3 inflammasome, but its mechanism was not fully understood. This article reviewed the progress about the effects of H₂S on NLRP3 inflammasome and its mechanisms involved in recent years to provide theoretical basis for in-depth study.

Keywords: Hydrogen sulfide, NLRP3 inflammasome, renal protection, neuroprotection, diabetes