Int J Biol Sci 2020; 16(14):2752-2760. doi:10.7150/ijbs.47595

Review

Hydrogen Sulfide Plays an Important Role by Influencing NLRP3 inflammasome

Honggang Wang1✉, Xingzhuo Shi2, Mengyuan Qiu1, Shuangyu Lv1, Hong Zheng1, Baohua Niu1, Huiyang Liu1

1. Institute of Biomedical Informatics, Bioinformatics Center, School of Basic Medical Sciences, Henan University, Kaifeng, Henan, 475000, China
2. School of Life Science, Henan University, Kaifeng, Henan, 475000, China

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Citation:
Wang H, Shi X, Qiu M, Lv S, Zheng H, Niu B, Liu H. Hydrogen Sulfide Plays an Important Role by Influencing NLRP3 inflammasome. Int J Biol Sci 2020; 16(14):2752-2760. doi:10.7150/ijbs.47595. Available from http://www.ijbs.com/v16p2752.htm

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Abstract

Inflammasome is a complex composed of several proteins and an important part of the natural immune system. Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is composed of NLRP3, apoptosis associated speck like protein (ASC) and pro-caspase-1. It plays an important role in many diseases. Hydrogen sulfide (H2S) is an important signaling molecule that regulates many physiological and pathological processes. Recent studies indicated that H2S played anti-inflammatory and pro-inflammatory roles in many diseases through influencing NLRP3 inflammasome, but its mechanism was not fully understood. This article reviewed the progress about the effects of H2S on NLRP3 inflammasome and its mechanisms involved in recent years to provide theoretical basis for in-depth study.

Keywords: Hydrogen sulfide, NLRP3 inflammasome, renal protection, neuroprotection, diabetes