Biological characteristics of IL-6 and related intestinal diseases

Yuexin Guo^1*, Boya Wang^2*, Tiantian Wang³, Lei Gao⁴, Ze-jun Yang⁵, Fei-fei Wang⁵, Hong-wei Shang⁶, Rongxuan Hua⁵, Jing-dong Xu^3✉

1. Department of Oral Medicine, Basic Medical College, Capital Medical University, Beijing 100069, China.
2. Undergraduate Student of 2018 Eight Program of Clinical Medicine, Peking University Health Science Center, Beijing, 100081, China.
3. Department of Physiology and Pathophysiology, Basic Medical College, Capital Medical University, Beijing 100069, China.
4. Department of Bioinformatics, College of Bioengineering, Capital Medical University, Beijing 100069, China.
5. Department of Clinical Medicine, Basic Medical College, Capital Medical University, Beijing 100069, China.
6. Experimental Center for Morphological Research Platform, Capital Medical University, Beijing 100069, China.
*These authors contributed equally to this work.

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Citation:
Guo Y, Wang B, Wang T, Gao L, Yang Zj, Wang Ff, Shang Hw, Hua R, Xu Jd. Biological characteristics of IL-6 and related intestinal diseases. Int J Biol Sci 2021; 17(1):204-219. doi:10.7150/ijbs.51362. Available from https://www.ijbs.com/v17p0204.htm

Abstract

The intestine serves as an important digestive and the largest immune organ in the body. Interleukin-6(IL-6), an important mediator of various pathways, participates in the interactions between different kinds of cells and closely correlates with intestinal physiological and pathological condition. In this review we summarize the signaling pathways of IL-6 and its functions in maintaining intestinal homeostasis. We also explored its relation with nervous system and highlight its potential role in Parkinson's disease. Based on its specialty of the double-side influences on intestinal tumors and inflammation, we summarize how they are done through distinctive process.

Keywords: Interleukin-6(IL-6), Intestinal diseases, Inflammation, Tumor, Nerve Immune barrier