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Volume 17 (1); 2021

Research Papers

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Clinical characteristics and analysis of risk factors for disease progression of COVID-19: A retrospective Cohort Study
Zhengtong Lv, Shubin Lv
Int. J. Biol. Sci. 2021; 17(1): 1-7. doi:10.7150/ijbs.50654
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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ACE2 Correlated With Immune Infiltration Serves As A Novel Prognostic Biomarker In Clear Cell Renal Cell Carcinoma: Implication For COVID-19
Wuping Yang, Lei Li, Kenan Zhang, Kaifang Ma, Haibiao Xie, Yanqing Gong, Jingcheng Zhou, Kan Gong
Int. J. Biol. Sci. 2021; 17(1): 20-31. doi:10.7150/ijbs.51969
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Eomesodermin in CD4+T cells is essential for Ginkgolide K ameliorating disease progression in experimental autoimmune encephalomyelitis
Sheng Chen, Juan Zhang, Wen-Bo Yu, Jing-Cong Zhuang, Wei Xiao, Zhi-Ying Wu, Bao-Guo Xiao
Int. J. Biol. Sci. 2021; 17(1): 50-61. doi:10.7150/ijbs.50041
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Deciphering the genomic and lncRNA landscapes of aerobic glycolysis identifies potential therapeutic targets in pancreatic cancer
Li-Li Zhu, Zheng Wu, Rong-Kun Li, Xin Xing, Yong-Sheng Jiang, Jun Li, Ya-Hui Wang, Li-Peng Hu, Xu Wang, Wei-Ting Qin, Yong-Wei Sun, Zhi-Gang Zhang, Qin Yang, Shu-Heng Jiang
Int. J. Biol. Sci. 2021; 17(1): 107-118. doi:10.7150/ijbs.49243
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Ferroptosis in a sarcopenia model of senescence accelerated mouse prone 8 (SAMP8)
Yan Huang, Beiling Wu, Dingzhu Shen, Jiulin Chen, Zhihua Yu, Chuan Chen
Int. J. Biol. Sci. 2021; 17(1): 151-162. doi:10.7150/ijbs.53126
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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MYC dysfunction modulates stemness and tumorigenesis in breast cancer
Yiqiu Liu, Chengjun Zhu, Lin Tang, Qin Chen, Nan Guan, Kun Xu, Xiaoxiang Guan
Int. J. Biol. Sci. 2021; 17(1): 178-187. doi:10.7150/ijbs.51458
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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PRPF6 promotes androgen receptor/androgen receptor-variant 7 actions in castration-resistant prostate cancer cells
Wei Liu, Chunyu Wang, Shengli Wang, Kai Zeng, Shan Wei, Ning Sun, Ge Sun, Manlin Wang, Renlong Zou, Wensu Liu, Lin Lin, Huijuan Song, Zining Jin, Yue Zhao
Int. J. Biol. Sci. 2021; 17(1): 188-203. doi:10.7150/ijbs.50810
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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HES1 promotes breast cancer stem cells by elevating Slug in triple-negative breast cancer
Xiaoying Li, Yang Li, Xianqiang Du, Xu Wang, Shu Guan, Yu Cao, Feng Jin, Feng Li
Int. J. Biol. Sci. 2021; 17(1): 247-258. doi:10.7150/ijbs.53477
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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NETO2 promotes esophageal cancer progression by inducing proliferation and metastasis via PI3K/AKT and ERK pathway
Jia-cheng Xu, Tian-yin Chen, Le-tai Liao, Tao Chen, Quan-lin Li, Jia-xin Xu, Jian-wei Hu, Ping-hong Zhou, Yi-qun Zhang
Int. J. Biol. Sci. 2021; 17(1): 259-270. doi:10.7150/ijbs.53795
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Novel Functions of CD147 in the Mitochondria Exacerbates Melanoma Metastasis
Lixia Lu, Jianglin Zhang, Pingping Gan, Lisha Wu, Xu Zhang, Cong peng, Jianda Zhou, Xiang Chen, Juan Su
Int. J. Biol. Sci. 2021; 17(1): 285-297. doi:10.7150/ijbs.52043
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The IFN-γ-IDO1-kynureine pathway-induced autophagy in cervical cancer cell promotes phagocytosis of macrophage
Shao-Liang Yang, Hai-Xia Tan, Tian-Tian Niu, Yu-Kai Liu, Chun-Jie Gu, Da-Jin Li, Ming-Qing Li, Hai-Yan Wang
Int. J. Biol. Sci. 2021; 17(1): 339-352. doi:10.7150/ijbs.51241
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CDH1 is Identified as A Therapeutic Target for Skin Regeneration after Mechanical Loading
Xiaolu Huang, Xiao Liang, Yiwen Zhou, Haizhou Li, Hengyu Du, Yinjun Suo, Wenhui Liu, Rui Jin, Bangda Chai, Ran Duan, Haizhou Li, Qingfeng Li
Int. J. Biol. Sci. 2021; 17(1): 353-367. doi:10.7150/ijbs.51309
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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Current advances in the development of SARS-CoV-2 vaccines
Annoor Awadasseid, Yanling Wu, Yoshimasa Tanaka, Wen Zhang
Int. J. Biol. Sci. 2021; 17(1): 8-19. doi:10.7150/ijbs.52569
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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βII spectrin (SPTBN1): biological function and clinical potential in cancer and other diseases
Panyu Yang, Yanyan Yang, Pin Sun, Yu Tian, Fang Gao, Chen Wang, Tingyu Zong, Min Li, Ying Zhang, Tao Yu, Zhirong Jiang
Int. J. Biol. Sci. 2021; 17(1): 32-49. doi:10.7150/ijbs.52375
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A Multiple-Hit Hypothesis Involving Reactive Oxygen Species and Myeloperoxidase Explains Clinical Deterioration and Fatality in COVID-19
Pravin T Goud, David Bai, Husam M Abu-Soud
Int. J. Biol. Sci. 2021; 17(1): 62-72. doi:10.7150/ijbs.51811
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Role of hydrogen sulfide donors in cancer development and progression
Ebenezeri Erasto Ngowi, Attia Afzal, Muhammad Sarfraz, Saadullah Khattak, Shams Uz Zaman, Nazeer Hussain Khan, Tao Li, Qi-Ying Jiang, Xin Zhang, Shao-Feng Duan, Xin-Ying Ji, Dong-Dong Wu
Int. J. Biol. Sci. 2021; 17(1): 73-88. doi:10.7150/ijbs.47850
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The Regulatory Effect of SIRT1 on Extracellular Microenvironment Remodeling
Zhuo Wang, Wendong Guo, Fei Yi, Tingting Zhou, Xiaoman Li, Yanling Feng, Qiqiang Guo, Hongde Xu, Xiaoyu Song, Liu Cao
Int. J. Biol. Sci. 2021; 17(1): 89-96. doi:10.7150/ijbs.52619
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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SARS-CoV-2 variants evolved during the early stage of the pandemic and effects of mutations on adaptation in Wuhan populations
Annoor Awadasseid, Yanling Wu, Yoshimasa Tanaka, Wen Zhang
Int. J. Biol. Sci. 2021; 17(1): 97-106. doi:10.7150/ijbs.47827
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Genome-to-phenome research in rats: progress and perspectives
Amy L. Zinski, Shane Carrion, Jennifer J. Michal, Maria A. Gartstein, Raymond M. Quock, Jon F. Davis, Zhihua Jiang
Int. J. Biol. Sci. 2021; 17(1): 119-133. doi:10.7150/ijbs.51628
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The Emerging Roles of Autophagy-Related MicroRNAs in Cancer
Chan Shan, Xinzhe Chen, Hongjing Cai, Xiaodan Hao, Jing Li, Yinfeng Zhang, Jinning Gao, Zhixia Zhou, Xinmin Li, Cuiyun Liu, Peifeng Li, Kun Wang
Int. J. Biol. Sci. 2021; 17(1): 134-150. doi:10.7150/ijbs.50773
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Regulation of exosome production and cargo sorting
Hong Wei, Qi Chen, Li Lin, Chunli Sha, Taoqiong Li, Yueqin Liu, Xinming Yin, Yuhao Xu, Lu Chen, Wujiang Gao, Yuefeng Li, Xiaolan Zhu
Int. J. Biol. Sci. 2021; 17(1): 163-177. doi:10.7150/ijbs.53671
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Biological characteristics of IL-6 and related intestinal diseases
Yuexin Guo, Boya Wang, Tiantian Wang, Lei Gao, Ze-jun Yang, Fei-fei Wang, Hong-wei Shang, Rongxuan Hua, Jing-dong Xu
Int. J. Biol. Sci. 2021; 17(1): 204-219. doi:10.7150/ijbs.51362
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Long Non-Coding RNAs: Potential Biomarkers and Targets for Hepatocellular Carcinoma Therapy and Diagnosis
Donghong Yuan, Yu Chen, Xiaobing Li, Jing Li, Yueshui Zhao, Jing Shen, Fukuan Du, Parham Jabbarzadeh Kaboli, Mingxing Li, Xu Wu, Huijiao Ji, Chi Hin Cho, Qinglian Wen, Wanping Li, Zhangang Xiao, Bo Chen
Int. J. Biol. Sci. 2021; 17(1): 220-235. doi:10.7150/ijbs.50730
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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miR-340: A multifunctional role in human malignant diseases
Zheng Huang, Yesha Xu, Maoping Wan, Xixi Zeng, Jianmin Wu
Int. J. Biol. Sci. 2021; 17(1): 236-246. doi:10.7150/ijbs.51123
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The emerging roles of m6A modification in liver carcinogenesis
Xue-yin Pan, Cheng Huang, Jun Li
Int. J. Biol. Sci. 2021; 17(1): 271-284. doi:10.7150/ijbs.50003
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A review of physiological and cellular mechanisms underlying fibrotic postoperative adhesion
Qiongyuan Hu, Xuefeng Xia, Xing Kang, Peng Song, Zhijian Liu, Meng Wang, Wenxian Guan, Song Liu
Int. J. Biol. Sci. 2021; 17(1): 298-306. doi:10.7150/ijbs.54403
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A perspective of intestinal immune-microbiome interactions in alcohol-associated Liver Disease
Ryan Bruellman
Int. J. Biol. Sci. 2021; 17(1): 307-327. doi:10.7150/ijbs.53589
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Potential roles of mediator Complex Subunit 13 in Cardiac Diseases
Wenqian Zhou, He Cai, Jia Li, He Xu, Xiang Wang, Hongbo Men, Yang Zheng, Lu Cai
Int. J. Biol. Sci. 2021; 17(1): 328-338. doi:10.7150/ijbs.52290
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Niche Cells Crosstalk In Neuroinflammation After Traumatic Brain Injury
Yibin Jia, Guanyi Wang, Yuqing Ye, Enming Kang, Huijun Chen, Zishuo Guo, Xiaosheng He
Int. J. Biol. Sci. 2021; 17(1): 368-378. doi:10.7150/ijbs.52169
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CircRNA ciRS-7: a Novel Oncogene in Multiple Cancers
Junwen Chen, Jun Yang, Xiang Fei, Xia Wang, Kefeng Wang
Int. J. Biol. Sci. 2021; 17(1): 379-389. doi:10.7150/ijbs.54292
[Abstract] [Full text] [PDF] [PubMed] [PMC]