The Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives

Li, Yifan; Lu, Lan; Wu, Xu; Li, Qianxiu; Zhao, Yueshui; Du, Fukuan; Chen, Yu; Shen, Jing; Xiao, Zhangang; Wu, Zhigui; Hu, Wei; Cho, Chi Hin; Li, Mingxing

doi:10.7150/ijbs.61410

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Theranostics

International Journal of Medical Sciences

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Int J Biol Sci 2021; 17(11):2737-2755. doi:10.7150/ijbs.61410 This issue Cite

Review

The Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives

Yifan Li^1,2#, Lan Lu^3#, Xu Wu^1,2✉, Qianxiu Li¹, Yueshui Zhao^1,2, Fukuan Du^1,2, Yu Chen^1,2, Jing Shen^1,2, Zhangang Xiao^1,2, Zhigui Wu^1,2,4, Wei Hu⁵, Chi Hin Cho^1,2, Mingxing Li^1,2✉

1. Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, Sichuan, China.
2. South Sichuan Institute of Translational Medicine, Luzhou 646000, Sichuan, China.
3. Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province,Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu 610106, Sichuan, China.
4. Department of Pharmacy, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China.
5. Department of Gastroenterology, Shenzhen Hospital, Southern Medical University, Shenzhen 518000, Guangzhou, China.
#These authors contributed equally to the work.

Citation:

Li Y, Lu L, Wu X, Li Q, Zhao Y, Du F, Chen Y, Shen J, Xiao Z, Wu Z, Hu W, Cho CH, Li M. The Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives. Int J Biol Sci 2021; 17(11):2737-2755. doi:10.7150/ijbs.61410. https://www.ijbs.com/v17p2737.htm

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Abstract

Gastric cancer (GC) is one of the major public health concerns. Long non-coding RNAs (lncRNAs) have been increasingly demonstrated to possess a strong correlation with GC and play a critical role in GC occurrence, progression, metastasis and drug resistance. Many studies have shed light on the understanding of the underlying mechanisms of lncRNAs in GC. In this review, we summarized the updated research about lncRNAs in GC, focusing on their roles in Helicobacter pylori infection, GC metastasis, tumor microenvironment regulation, drug resistance and associated signaling pathways. LncRNAs may serve as novel biomarkers for diagnosis and prognosis of GC and potential therapeutic targets. The research gaps and future directions were also discussed.

Keywords: long non-coding RNA, gastric cancer, drug resistance, helicobacter pylori, tumor microenvironment

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APA

Li, Y., Lu, L., Wu, X., Li, Q., Zhao, Y., Du, F., Chen, Y., Shen, J., Xiao, Z., Wu, Z., Hu, W., Cho, C.H., Li, M. (2021). The Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives. International Journal of Biological Sciences, 17(11), 2737-2755. https://doi.org/10.7150/ijbs.61410.

ACS

Li, Y.; Lu, L.; Wu, X.; Li, Q.; Zhao, Y.; Du, F.; Chen, Y.; Shen, J.; Xiao, Z.; Wu, Z.; Hu, W.; Cho, C.H.; Li, M. The Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives. Int. J. Biol. Sci. 2021, 17 (11), 2737-2755. DOI: 10.7150/ijbs.61410.

NLM

CSE

Li Y, Lu L, Wu X, Li Q, Zhao Y, Du F, Chen Y, Shen J, Xiao Z, Wu Z, Hu W, Cho CH, Li M. 2021. The Multifaceted Role of Long Non-Coding RNA in Gastric Cancer: Current Status and Future Perspectives. Int J Biol Sci. 17(11):2737-2755.

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