Partial EMT in Squamous Cell Carcinoma: A Snapshot

Liao, Chengcheng; Wang, Qian; An, Jiaxing; Long, Qian; Wang, Hui; Xiang, Meiling; Xiang, Mingli; Zhao, Yujie; Liu, Yulin; Liu, Jianguo; Guan, Xiaoyan

doi:10.7150/ijbs.61566

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Theranostics

International Journal of Medical Sciences

Nanotheranostics

Journal of Cancer

Journal of Genomics

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Int J Biol Sci 2021; 17(12):3036-3047. doi:10.7150/ijbs.61566 This issue Cite

Review

Partial EMT in Squamous Cell Carcinoma: A Snapshot

Chengcheng Liao^1,2, Qian Wang^2,4, Jiaxing An³, Qian Long^1,2, Hui Wang³, Meiling Xiang¹, Mingli Xiang¹, Yujie Zhao^1,2, Yulin Liu^1,2, Jianguo Liu^1,2✉, Xiaoyan Guan^1✉

1. Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi 563000, China
2. Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical University, Zunyi 563006, China
3. Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China
4. Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution, Life Sciences Institute, Zunyi Medical University, Zunyi 563006, China

Citation:

Liao C, Wang Q, An J, Long Q, Wang H, Xiang M, Xiang M, Zhao Y, Liu Y, Liu J, Guan X. Partial EMT in Squamous Cell Carcinoma: A Snapshot. Int J Biol Sci 2021; 17(12):3036-3047. doi:10.7150/ijbs.61566. https://www.ijbs.com/v17p3036.htm

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Abstract

In the process of cancer EMT, some subgroups of cancer cells simultaneously exhibit both mesenchymal and epithelial characteristics, a phenomenon termed partial EMT (pEMT). pEMT is a plastic state in which cells coexpress epithelial and mesenchymal markers. In squamous cell carcinoma (SCC), pEMT is regulated, and the phenotype is maintained via the HIPPO pathway, NOTCH pathway and TGF-β pathways and by microRNAs, lncRNAs and the cancer microenvironment (CME); thus, SCC exhibits aggressive tumorigenic properties and high stemness, which leads collective migration and therapy resistance. Few studies have reported therapeutic interventions to address cells that have undergone pEMT, and this approach may be an effective way to inhibit the plasticity, drug resistance and metastatic potential of SCC.

Keywords: Partial EMT, Squamous Cell Carcinoma, FAT1, HIPPO, NOTCH, TGF-β, Collective migration, Stemness, Therapeutic resistance

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APA

Liao, C., Wang, Q., An, J., Long, Q., Wang, H., Xiang, M., Xiang, M., Zhao, Y., Liu, Y., Liu, J., Guan, X. (2021). Partial EMT in Squamous Cell Carcinoma: A Snapshot. International Journal of Biological Sciences, 17(12), 3036-3047. https://doi.org/10.7150/ijbs.61566.

ACS

Liao, C.; Wang, Q.; An, J.; Long, Q.; Wang, H.; Xiang, M.; Xiang, M.; Zhao, Y.; Liu, Y.; Liu, J.; Guan, X. Partial EMT in Squamous Cell Carcinoma: A Snapshot. Int. J. Biol. Sci. 2021, 17 (12), 3036-3047. DOI: 10.7150/ijbs.61566.

NLM

CSE

Liao C, Wang Q, An J, Long Q, Wang H, Xiang M, Xiang M, Zhao Y, Liu Y, Liu J, Guan X. 2021. Partial EMT in Squamous Cell Carcinoma: A Snapshot. Int J Biol Sci. 17(12):3036-3047.

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