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Volume 17 (12); 2021

Research Papers

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The MEK inhibitor U0126 ameliorates diabetic cardiomyopathy by restricting XBP1's phosphorylation dependent SUMOylation
Tao Wang, Jinhua Wu, Wei Dong, Mengwen Wang, Xiaodan Zhong, Wenjun Zhang, Lei Dai, Yang Xie, Yujian Liu, Xingwei He, Wanjun Liu, Thati Madhusudhan, Hesong Zeng, Hongjie Wang
Int. J. Biol. Sci. 2021; 17(12): 2984-2999. doi:10.7150/ijbs.60459
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway
Bin Zeng, Zhiwei Sun, Qiting Zhao, Doudou Liu, Hao chen, Xiaoshuang Li, H. Rosie Xing, Jianyu Wang
Int. J. Biol. Sci. 2021; 17(12): 3000-3012. doi:10.7150/ijbs.60866
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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CD147 confers temozolomide resistance of glioma cells via the regulation of β-TrCP/Nrf2 pathway
Xin Bu, Xuan Qu, Kai Guo, Xiangliang Meng, Xing Yang, Qike Huang, Wenjie Dou, Lin Feng, Xinxin Wei, Jiwei Gao, Wei Sun, Min Chao, Liying Han, Yaqin Hu, Liangliang Shen, Jian Zhang, Liang Wang
Int. J. Biol. Sci. 2021; 17(12): 3013-3023. doi:10.7150/ijbs.60894
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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UBE3A activates the NOTCH pathway and promotes esophageal cancer progression by degradation of ZNF185
Zhikun Zheng, Bin Zhang, Haixin Yu, Shoukang Li, Naicheng Song, Xin Jin, Jinsong Li
Int. J. Biol. Sci. 2021; 17(12): 3024-3035. doi:10.7150/ijbs.61117
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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ELTD1 promotes invasion and metastasis by activating MMP2 in colorectal cancer
Jiawei Sun, Zizheng Zhang, Jingyu Chen, Meng Xue, Xia Pan
Int. J. Biol. Sci. 2021; 17(12): 3048-3058. doi:10.7150/ijbs.62293
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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URI1 suppresses irradiation-induced reactive oxygen species (ROS) by activating autophagy in hepatocellular carcinoma cells
Yue Xu, Yuan Ji, Xiang Li, JiaZheng Ding, LinQi Chen, YaFeng Huang, Wenxiang Wei
Int. J. Biol. Sci. 2021; 17(12): 3091-3103. doi:10.7150/ijbs.55689
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Circular RNA circBCBM1 promotes breast cancer brain metastasis by modulating miR-125a/BRD4 axis
Bo Fu, Wei Liu, Cui Zhu, Peng Li, Li Wang, Li Pan, Ke Li, Peiying Cai, Min Meng, Yiting Wang, Anqi Zhang, Wenqiang Tang, Meng An
Int. J. Biol. Sci. 2021; 17(12): 3104-3117. doi:10.7150/ijbs.58916
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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NCTD Prevents Renal Interstitial Fibrosis via Targeting Sp1/lncRNA Gm26669 Axis
Jiao Tian, Zheng Xiao, Ju Wei, Yi Shan, Dong Zeng, Yilin Tao, Xi Fang, Chengyuan Tang, Xiaojun Chen, Ying Li
Int. J. Biol. Sci. 2021; 17(12): 3118-3132. doi:10.7150/ijbs.59195
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Genome-scale CRISPRa screening identifies MTX1 as a contributor for sorafenib resistance in hepatocellular carcinoma by augmenting autophagy
Li Li, Shijun Yu, Qingqing Hu, Yanan Hai, Yandong Li
Int. J. Biol. Sci. 2021; 17(12): 3133-3144. doi:10.7150/ijbs.62393
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Inhibition of protein PMP22 enhances etoposide-induced cell apoptosis by p53 signaling pathway in Gastric Cancer
Jingjing Hou, Lin Wang, Jiabao Zhao, Huiqin Zhuo, Jia Cheng, Xin Chen, Wei Zheng, Zhijun Hong, Jianchun Cai
Int. J. Biol. Sci. 2021; 17(12): 3145-3157. doi:10.7150/ijbs.59825
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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DDX39 as a predictor of clinical prognosis and immune checkpoint therapy efficacy in patients with clear cell renal cell carcinoma
Yewei Bao, Aimin Jiang, Kai Dong, Xinxin Gan, Wenliang Gong, Zhenjie Wu, Bing Liu, Yi Bao, Jie Wang, Linhui Wang
Int. J. Biol. Sci. 2021; 17(12): 3158-3172. doi:10.7150/ijbs.62553
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Berberine modulates deacetylation of PPARγ to promote adipose tissue remodeling and thermogenesis via AMPK/SIRT1 pathway
Yingxi Xu, Tianhao Yu, Guojing Ma, Lixia Zheng, Xuehan Jiang, Fan Yang, Zhuo Wang, Na Li, Zheng He, Xiaoyu Song, Deliang Wen, Juan Kong, Yang Yu, Liu Cao
Int. J. Biol. Sci. 2021; 17(12): 3173-3187. doi:10.7150/ijbs.62556
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Rapamycin and trametinib: a rational combination for treatment of NSCLC
Chao-Yue Sun, Yi-Zhuo Li, Di Cao, Yu-Feng Zhou, Mei-Yin Zhang, Hui-Yun Wang
Int. J. Biol. Sci. 2021; 17(12): 3211-3223. doi:10.7150/ijbs.62752
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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BC-N102 suppress breast cancer tumorigenesis by interfering with cell cycle regulatory proteins and hormonal signaling, and induction of time-course arrest of cell cycle at G1/G0 phase
Bashir Lawal, Yu-Cheng Kuo, Alexander T. H. Wu, Hsu-Shan Huang
Int. J. Biol. Sci. 2021; 17(12): 3224-3238. doi:10.7150/ijbs.62808
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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BRCA1 Antibodies Matter
Jing Yang, Leilei Qi, Huai-Chin Chiang, Bin Yuan, Rong Li, Yanfen Hu
Int. J. Biol. Sci. 2021; 17(12): 3239-3254. doi:10.7150/ijbs.63115
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Discovery and Validation of Nitroxoline as a Novel STAT3 Inhibitor in Drug-resistant Urothelial Bladder Cancer
Wenfeng Lin, Jingkai Sun, Takuya Sadahira, Naijin Xu, Koichiro Wada, Chunxiao Liu, Motoo Araki, Abai Xu, Masami Watanabe, Yasutomo Nasu, Peng Huang
Int. J. Biol. Sci. 2021; 17(12): 3255-3267. doi:10.7150/ijbs.63125
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

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Partial EMT in Squamous Cell Carcinoma: A Snapshot
Chengcheng Liao, Qian Wang, Jiaxing An, Qian Long, Hui Wang, Meiling Xiang, Mingli Xiang, Yujie Zhao, Yulin Liu, Jianguo Liu, Xiaoyan Guan
Int. J. Biol. Sci. 2021; 17(12): 3036-3047. doi:10.7150/ijbs.61566
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The functional roles, cross-talk and clinical implications of m6A modification and circRNA in hepatocellular carcinoma
Sha Qin, Yitao Mao, Xue Chen, Juxiong Xiao, Yan Qin, Luqing Zhao
Int. J. Biol. Sci. 2021; 17(12): 3059-3079. doi:10.7150/ijbs.62767
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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ATM at the crossroads of reactive oxygen species and autophagy
Xiaochen Xie, Ye Zhang, Zhuo Wang, Shanshan Wang, Xiaoyou Jiang, Hongyan Cui, Tingting Zhou, Zheng He, Hao Feng, Qiqiang Guo, Xiaoyu Song, Liu Cao
Int. J. Biol. Sci. 2021; 17(12): 3080-3090. doi:10.7150/ijbs.63963
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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LncRNA H19: A novel oncogene in multiple cancers
Jun Yang, Manlong Qi, Xiang Fei, Xia Wang, Kefeng Wang
Int. J. Biol. Sci. 2021; 17(12): 3188-3208. doi:10.7150/ijbs.62573
[Abstract] [Full text] [PDF] [PubMed] [PMC]