Int J Biol Sci 2021; 17(14):3981-3992. doi:10.7150/ijbs.63556 This issue

Review

Enolase 1, a Moonlighting Protein, as a Potential Target for Cancer Treatment

Gan Qiao1,2, Anguo Wu3,4, Xiaoliang Chen5, Ye Tian6, Xiukun Lin7✉

1. School of Pharmacy, Southwest Medical University, Luzhou, 646000, China (Q.G, dqz377977905@swmu.edu.cn).
2. School of Pharmacy, Central Nervous System Drug Key Laboratory of Sichuan Province, Southwest Medical University, Luzhou, 646000, China.
3. Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Drugability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, 646000, China.
4. Education Ministry Key Laboratory of Medical Electrophysiology, Southwest Medical University, Luzhou, 646000, China.
5. Schools of Medicine; Shanxi Datong University, Datong, Shanxi, 037009, China.
6. The Eighth Affiliated Hospital Sun Yat-sen University,Shenzhen, Guangdong, China.
7. College of Life Sci., Shandong University of Technology, Zibo, Shandong, China.

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Citation:
Qiao G, Wu A, Chen X, Tian Y, Lin X. Enolase 1, a Moonlighting Protein, as a Potential Target for Cancer Treatment. Int J Biol Sci 2021; 17(14):3981-3992. doi:10.7150/ijbs.63556. Available from https://www.ijbs.com/v17p3981.htm

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Abstract

Graphic abstract

Enolase 1 (ENO1) is a moonlighting protein, function as a glycolysis enzyme, a plasminogen receptor and a DNA binding protein. ENO1 play an important role in the process of cancer development. The transcription, translation, post-translational modifying activities and the immunoregulatory role of ENO1 at the cancer development is receiving increasing attention. Some function model studies have shown that ENO1 is a potential target for cancer treatment. In this review, we provide a comprehensive overview of the characterization, function, related transduction cascades of ENO1 and its roles in the pathophysiology of cancers, which is a consequence of ENO1 signaling dysregulation. And the development of novels anticancer agents that targets ENO1 may provide a more attractive option for the treatment of cancers. The data of sarcoma and functional cancer models indicates that ENO1 may become a new potential target for anticancer therapy.

Keywords: Enolase 1, Moonlighting Protein, transduction cascades, Cancer treatment