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Volume 17 (14); 2021

Research Papers

Cancer-associated fibroblasts-derived exosomal miR-3656 promotes the development and progression of esophageal squamous cell carcinoma via the ACAP2/PI3K-AKT signaling pathway
Yuan Jin, Qilin Meng, Bihui Zhang, Chen Xie, Xue Chen, Baoqing Tian, Jiakang Wang, Tsung-Chieh Shih, Yibo Zhang, Jieqiong Cao, Yiqi Yang, Size Chen, Xinyuan Guan, Xiaojia Chen, An Hong
Int. J. Biol. Sci. 2021; 17(14): 3689-3701. doi:10.7150/ijbs.62571
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Suppression of neuronal cholesterol biosynthesis impairs brain functions through insulin-like growth factor I-Akt signaling
Ting Liu, Yang Li, Baoyu Yang, Haozhen Wang, Chen Lu, Alan K Chang, Xiuting Huang, Xiujin Zhang, Ziyin Lu, Xiuli Lu, Bing Gao
Int. J. Biol. Sci. 2021; 17(14): 3702-3716. doi:10.7150/ijbs.63512
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Gene Presence/Absence Variation analysis of coronavirus family displays its pan-genomic diversity
Du Jiao, Xiaorui Dong, Yingyan Yu, Chaochun Wei
Int. J. Biol. Sci. 2021; 17(14): 3717-3727. doi:10.7150/ijbs.58220
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Melatonin and hyperbaric oxygen therapies suppress colorectal carcinogenesis through pleiotropic effects and multifaceted mechanisms
Yi-Chen Li, Chih-Hung Chen, Chia-Lo Chang, John Yi-Wu Chiang, Chi-Hsiang Chu, Hong-Hwa Chen, Hon-Kan Yip
Int. J. Biol. Sci. 2021; 17(14): 3728-3744. doi:10.7150/ijbs.62280
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Lipotoxic hepatocytes promote nonalcoholic fatty liver disease progression by delivering microRNA-9-5p and activating macrophages
Hanyun Liu, Qinghui Niu, Ting Wang, Hongjing Dong, Cheng Bian
Int. J. Biol. Sci. 2021; 17(14): 3745-3759. doi:10.7150/ijbs.57610
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Single-cell RNA sequencing reveals spatiotemporal heterogeneity and malignant progression in pancreatic neuroendocrine tumor
Yu Zhou, Siyang Liu, Chao Liu, Jiabin Yang, Qing Lin, Shangyou Zheng, Changhao Chen, Quanbo Zhou, Rufu Chen
Int. J. Biol. Sci. 2021; 17(14): 3760-3775. doi:10.7150/ijbs.61717
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YTHDF2 Suppresses Notch Signaling through Post-transcriptional Regulation on Notch1
Byongsun Lee, Seungjae Lee, Jaekyung Shim
Int. J. Biol. Sci. 2021; 17(14): 3776-3785. doi:10.7150/ijbs.61573
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Receptor-binding domain of SARS-CoV-2 spike protein efficiently inhibits SARS-CoV-2 infection and attachment to mouse lung
Hye Jin Shin, Keun Bon Ku, Hae Soo Kim, Hyun Woo Moon, Gi Uk Jeong, Insu Hwang, Gun Young Yoon, Sunhee Lee, Sumin Lee, Dae-Gyun Ahn, Kyun-Do Kim, Young-Chan Kwon, Bum-Tae Kim, Seong-Jun Kim, Chonsaeng Kim
Int. J. Biol. Sci. 2021; 17(14): 3786-3794. doi:10.7150/ijbs.61320
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Comprehensive landscape of the renin-angiotensin system in Pan-cancer: a potential downstream mediated mechanism of SARS-CoV-2
Yuqing Cui, Fengzhi Chen, Jiayi Gao, Mengxia Lei, Dandan Wang, Xiaoying Jin, Yan Guo, Liying Shan, Xuesong Chen
Int. J. Biol. Sci. 2021; 17(14): 3795-3817. doi:10.7150/ijbs.53312
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Melittin-loaded Iron Oxide Nanoparticles Prevent Intracranial Arterial Dolichoectasia Development through Inhibition of Macrophage-mediated Inflammation
Huy Duc Vu, Phuong Tu Huynh, Junghwa Ryu, Ung Rae Kang, Sung Won Youn, Hongtae Kim, Hyun Jin Ahn, Kwankyu Park, Soon-Kyung Hwang, Young-Chae Chang, Yong Jig Lee, Hui Joong Lee, Jongmin Lee
Int. J. Biol. Sci. 2021; 17(14): 3818-3836. doi:10.7150/ijbs.60588
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Development of mesothelin-specific CAR NK-92 cells for the treatment of gastric cancer
Bihui Cao, Manting Liu, Jingjun Huang, Jingwen Zhou, Junping Li, Hui Lian, Wensou Huang, Yongjian Guo, Shuo Yang, Liteng Lin, Mingyue Cai, Cheng Zhi, Jingqiang Wu, Licong Liang, Yuling Hu, Hong Hu, Jinping He, Baoxia Liang, Qi Zhao, Kangshun Zhu
Int. J. Biol. Sci. 2021; 17(14): 3850-3861. doi:10.7150/ijbs.64630
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FGF7-induced E11 facilitates cell-cell communication through connexin43
Xiaoyu Liu, Mingru Bai, Yimin Sun, Xuchen Hu, Chenglin Wang, Jing Xie, Ling Ye
Int. J. Biol. Sci. 2021; 17(14): 3862-3874. doi:10.7150/ijbs.65240
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Up-regulation of MELK by E2F1 promotes the proliferation in cervical cancer cells
Hongzhi Sun, Hongmei Ma, Hao Zhang, Minjun Ji
Int. J. Biol. Sci. 2021; 17(14): 3875-3888. doi:10.7150/ijbs.62517
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The intraviral protein-protein interaction of SARS-CoV-2 reveals the key role of N protein in virus-like particle assembly
Minghai Chen, Chuang Yan, Fujun Qin, Luping Zheng, Xian-En Zhang
Int. J. Biol. Sci. 2021; 17(14): 3889-3897. doi:10.7150/ijbs.64977
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ADAM9 functions as a transcriptional regulator to drive angiogenesis in esophageal squamous cell carcinoma
Yu-Sen Lin, Ting-Ting Kuo, Chia-Chien Lo, Wei-Chung Cheng, Wei-Chao Chang, Guan-Chin Tseng, Shih-Ting Bai, Yu-Kai Huang, Chih-Ying Hsieh, Han-Shui Hsu, Yi-Fan Jiang, Chen-Yuan Lin, Liang-Chuan Lai, Xing-Guo Li, Yuh-Pyng Sher
Int. J. Biol. Sci. 2021; 17(14): 3898-3910. doi:10.7150/ijbs.65488
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Deletion of Smad3 protects against C-reactive protein-induced renal fibrosis and inflammation in obstructive nephropathy
Yong-Ke You, Wei-Feng Wu, Xiao-Ru Huang, Hai-Di Li, Ye-Ping Ren, Jin-Cheng Zeng, Haiyong Chen, Hui Yao Lan
Int. J. Biol. Sci. 2021; 17(14): 3911-3922. doi:10.7150/ijbs.62929
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Lrp6 Genotype affects Individual Susceptibility to Nonalcoholic Fatty Liver Disease and Silibinin Therapeutic Response via Wnt/β-catenin-Cyp2e1 Signaling
Li-Jie Chen, Xiu-Xian Lin, Jing Guo, Ying Xu, Song-Xia Zhang, Dan Chen, Qing Zhao, Jian Xiao, Guang-Hui Lian, Shi-Fang Peng, Dong Guo, Hong Yang, Yan Shu, Hong-Hao Zhou, Wei Zhang, Yao Chen
Int. J. Biol. Sci. 2021; 17(14): 3936-3953. doi:10.7150/ijbs.63732
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COVID-19 disease and malignant cancers: The impact for the furin gene expression in susceptibility to SARS-CoV-2
Dabing Li, Xiaoyan Liu, Lianmei Zhang, Jiayue He, Xianmao Chen, Shuguang Liu, Jiewen Fu, Shangyi Fu, Hanchun Chen, Junjiang Fu, Jingliang Cheng
Int. J. Biol. Sci. 2021; 17(14): 3954-3967. doi:10.7150/ijbs.63072
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Long non-coding RNA MEG3 promotes cisplatin-induced nephrotoxicity through regulating AKT/TSC/mTOR-mediated autophagy
Xu Jing, Jinming Han, Junhao Zhang, Yi Chen, Juan Yuan, Jue Wang, Shiyong Neo, Shuijie Li, Xueyuan Yu, Jing Wu
Int. J. Biol. Sci. 2021; 17(14): 3968-3980. doi:10.7150/ijbs.58910
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The imbalance of PGD2-DPs pathway is involved in the type 2 diabetes brain injury by regulating autophagy
Yang Yang, Pu Xiang, Qi Chen, Ying Luo, Hong Wang, Huan Li, Lu Yang, Congli Hu, Jiahua Zhang, Yuke Li, Hui Xia, Zhihao Chen, Junqing Yang
Int. J. Biol. Sci. 2021; 17(14): 3993-4004. doi:10.7150/ijbs.60149
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PRG-1 relieves pain and depressive-like behaviors in rats of bone cancer pain by regulation of dendritic spine in hippocampus
Xingfeng Liu, Zhuo Xie, Site Li, Jingxin He, Song Cao, Zhi Xiao
Int. J. Biol. Sci. 2021; 17(14): 4005-4020. doi:10.7150/ijbs.59032
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Tubular cell-derived exosomal miR-150-5p contributes to renal fibrosis following unilateral ischemia-reperfusion injury by activating fibroblast in vitro and in vivo
Xiangjun Zhou, Sheng Zhao, Wei Li, Yuan Ruan, Run Yuan, Jinzhuo Ning, Kun Jiang, Jinna Xie, Xiaobin Yao, Haoyong Li, Chenglong Li, Ting Rao, Weimin Yu, Fan Cheng
Int. J. Biol. Sci. 2021; 17(14): 4021-4033. doi:10.7150/ijbs.62478
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Reviews

Immunotherapy in colorectal cancer: current achievements and future perspective
Ahui Fan, Boda Wang, Xin Wang, Yongzhan Nie, Daiming Fan, Xiaodi Zhao, Yuanyuan Lu
Int. J. Biol. Sci. 2021; 17(14): 3837-3849. doi:10.7150/ijbs.64077
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Role of mismatch repair in aging
Jie Wen, Yangyang Wang, Minghao Yuan, Zhenting Huang, Qian Zou, Yinshuang Pu, Bin Zhao, Zhiyou Cai
Int. J. Biol. Sci. 2021; 17(14): 3923-3935. doi:10.7150/ijbs.64953
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Enolase 1, a Moonlighting Protein, as a Potential Target for Cancer Treatment
Gan Qiao, Anguo Wu, Xiaoliang Chen, Ye Tian, Xiukun Lin
Int. J. Biol. Sci. 2021; 17(14): 3981-3992. doi:10.7150/ijbs.63556
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The Role of p38γ in Cancer: From review to outlook
Wentao Xu, Rui Liu, Ying Dai, Shaocheng Hong, Huke Dong, Hua Wang
Int. J. Biol. Sci. 2021; 17(14): 4036-4046. doi:10.7150/ijbs.63537
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Post-Translational Modifications of PCNA in Control of DNA Synthesis and DNA Damage Tolerance-the Implications in Carcinogenesis
Siyi Zhang, Tingting Zhou, Zhuo Wang, Fei Yi, Chunlu Li, Wendong Guo, Hongde Xu, Hongyan Cui, Xiang Dong, Jingwei Liu, Xiaoyu Song, Liu Cao
Int. J. Biol. Sci. 2021; 17(14): 4047-4059. doi:10.7150/ijbs.64628
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The Hippo pathway: a renewed insight in the craniofacial diseases and hard tissue remodeling
Jun Chen, Jingyi Cheng, Cong Zhao, Boxuan Zhao, Jia Mi, Wenjie Li
Int. J. Biol. Sci. 2021; 17(14): 4060-4072. doi:10.7150/ijbs.63305
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Respiratory syncytial virus: from pathogenesis to potential therapeutic strategies
Zifang Shang, Shuguang Tan, Dongli Ma
Int. J. Biol. Sci. 2021; 17(14): 4073-4091. doi:10.7150/ijbs.64762
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Erratum

MiR-487a Promotes TGF-β1-induced EMT, the Migration and Invasion of Breast Cancer Cells by Directly Targeting MAGI2
Mengtao Ma, Miao He, Qian Jiang, Yuanyuan Yan, Shu Guan, Jing Zhang, Zhaojin Yu, Qiuchen Chen, Mingli Sun, Weifan Yao, Haishan Zhao, Feng Jin, Minjie Wei
Int. J. Biol. Sci. 2021; 17(14): 4034-4035. doi:10.7150/ijbs.67062
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