Int J Biol Sci 2021; 17(14):4036-4046. doi:10.7150/ijbs.63537 This issue

Review

The Role of p38γ in Cancer: From review to outlook

Wentao Xu1,2*, Rui Liu1*, Ying Dai1, Shaocheng Hong2, Huke Dong2, Hua Wang1,3✉

1. Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China.
2. First Clinical Medical College of Anhui Medical University, Hefei, 230032, Anhui, China.
3. Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, 230032, Anhui, China.
*These authors contributed equally to this work.

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Citation:
Xu W, Liu R, Dai Y, Hong S, Dong H, Wang H. The Role of p38γ in Cancer: From review to outlook. Int J Biol Sci 2021; 17(14):4036-4046. doi:10.7150/ijbs.63537. Available from https://www.ijbs.com/v17p4036.htm

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Abstract

Graphic abstract

p38γ is a member of the p38 Mitogen Activated Protein Kinases (p38 MAPKs). It contains four subtypes in mammalian cells encoded by different genes including p38α (MAPK14), p38β (MAPK11), p38γ (MAPK12), and p38δ (MAPK13). Recent studies revealed that p38γ may exhibit a crucial role in tumorigenesis and cancer aggressiveness. Despite the large number of published literatures, further researches are demanded to clarify its role in cancer development, the tissue-specific function and associated novel treatment strategies. In this article, we provide the latest view on the connection between p38γ and malignant tumors, highlighting the function of p38γ. The clinical value of p38γ is also discussed, helping the translation into the remarkable therapeutic strategy in tumor diseases.

Keywords: p38γ, molecular pathway, intestinal microbes, gene editing, immunotherapy