Int J Biol Sci 2021; 17(14):4060-4072. doi:10.7150/ijbs.63305 This issue

Review

The Hippo pathway: a renewed insight in the craniofacial diseases and hard tissue remodeling

Jun Chen, DDS, MSD1,2,3*, Jingyi Cheng1*, Cong Zhao1, Boxuan Zhao1, Jia Mi1, Wenjie Li, DDS, MSD, MSc1,2,3,4,5✉

1. Xiangya School of Stomatology, Central South University, Changsha 410008, China.
2. Xiangya Stomatological Hospital, Central South University, Changsha 410008, China.
3. Hunan Key Laboratory of Oral Health Research, Hunan 3D Printing Engineering Research Center of Oral Care, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Central South University, Changsha 410008, China.
4. National Key Laboratory of Science and Technology on High-strength Structural Materials, Central South University, Changsha 410083, China.
5. State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China.
*These authors contributed equally to this work.

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Citation:
Chen J, Cheng J, Zhao C, Zhao B, Mi J, Li W. The Hippo pathway: a renewed insight in the craniofacial diseases and hard tissue remodeling. Int J Biol Sci 2021; 17(14):4060-4072. doi:10.7150/ijbs.63305. Available from https://www.ijbs.com/v17p4060.htm

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Abstract

Graphic abstract

The Hippo pathway plays an important role in many pathophysiological processes, including cell proliferation and differentiation, cell death, cell migration and invasion. Because of its extensive functions, Hippo pathway is closely related to not only growth and development, but also many diseases, including inflammation and cancer. In this study, the role of Hippo pathway in craniofacial diseases and hard tissue remodeling was reviewed, in attempting to find new research directions.

Keywords: Hippo signaling pathway, YAP, TAZ, periodontal diseases, oral submucous fibrosis, craniofacial diseases