Int J Biol Sci 2022; 18(3):1211-1219. doi:10.7150/ijbs.67529 This issue

Review

DNA Replication Licensing Factors: Novel Targets for Cancer Therapy via Inhibiting the Stemness of Cancer Cells

Shaoran Song1,2, Yaochun Wang1,2✉, Peijun Liu1,2✉

1. Center for Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
2. The Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China

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Citation:
Song S, Wang Y, Liu P. DNA Replication Licensing Factors: Novel Targets for Cancer Therapy via Inhibiting the Stemness of Cancer Cells. Int J Biol Sci 2022; 18(3):1211-1219. doi:10.7150/ijbs.67529. Available from https://www.ijbs.com/v18p1211.htm

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Abstract

Graphic abstract

The replication licensing factors strictly regulate the DNA replication origin licensing process to guarantee the stability of the genome. Numerous experimental studies have recently demonstrated that the replication licensing factors as oncogenes are essential for the occurrence and development of cancers. Drug resistance, being one of the main characteristics of cancer stem cells, can cause a high recurrence rate and a low survival rate in patients with different cancers. However, the function of the replication licensing factors in cancer stemness remains unclear. The following article highlights the most recent research on DNA replication origin licensing factors in cancer and their function in anti-cancer drug resistance. Moreover, this article proposes a new perspective that replication licensing factors as chemotherapy shield affect anti-cancer drug resistance by promoting the stemness of cancer cells.

Keywords: replication initiation factors, cancer stem cell, stemness, drug resistance