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Int J Biol Sci 2022; 18(4):1451-1475. doi:10.7150/ijbs.68170 This issue Cite

Review

The Effects and Mechanisms of Flavonoids on Cancer Prevention and Therapy: Focus on Gut Microbiota

Man Wang1✉, Fei Yu1, Yuan Zhang1, Wenguang Chang1, Meng Zhou2✉

1. Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, 38 Dengzhou Road, Qingdao, 266021, Shandong, China.
2. Department of Dermatology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Qingdao, 266035, Shandong, China.

✉ Corresponding authors: Man Wang, Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, 38 Dengzhou Road, Qingdao, 266021, Shandong, China. E-mail: wangmanedu.cn; Meng Zhou, More

Citation:
Wang M, Yu F, Zhang Y, Chang W, Zhou M. The Effects and Mechanisms of Flavonoids on Cancer Prevention and Therapy: Focus on Gut Microbiota. Int J Biol Sci 2022; 18(4):1451-1475. doi:10.7150/ijbs.68170. https://www.ijbs.com/v18p1451.htm
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Abstract

Graphic abstract

Flavonoids are a group of polyphenolic compounds which are ubiquitously found in plants and are consumed as part of the human diet in substantial amounts. The verification of flavonoids' cancer chemopreventive benefits has led to a significant interest in this field. Gut microbiota includes a diverse community of microorganisms and has a close relationship with cancer development. Increasing evidence has indicated that flavonoids exert anticarcinogenic effects by reshaping gut microbiota. Gut microbiota can convert flavonoids into bioactive metabolites that possess anticancer activity. Here, we present a brief introduction to gut microbiota and provide an overview of the interplay between gut microbiota and cancer pathogenesis. We also highlight the crucial roles of flavonoids in preventing cancer based on their regulation of gut microbiota. This review would encourage research on the flavonoid-intestinal microbiota interactions and clinical trials to validate the chemotherapeutic potentials of targeting gut microbiota by dietary bioactive compounds.

Keywords: flavonoids, cancer, chemopreventive benefits, gut microbiota, bioactive metabolites

Citation styles

APA
Wang, M., Yu, F., Zhang, Y., Chang, W., Zhou, M. (2022). The Effects and Mechanisms of Flavonoids on Cancer Prevention and Therapy: Focus on Gut Microbiota. International Journal of Biological Sciences, 18(4), 1451-1475. https://doi.org/10.7150/ijbs.68170.

ACS
Wang, M.; Yu, F.; Zhang, Y.; Chang, W.; Zhou, M. The Effects and Mechanisms of Flavonoids on Cancer Prevention and Therapy: Focus on Gut Microbiota. Int. J. Biol. Sci. 2022, 18 (4), 1451-1475. DOI: 10.7150/ijbs.68170.

NLM
Wang M, Yu F, Zhang Y, Chang W, Zhou M. The Effects and Mechanisms of Flavonoids on Cancer Prevention and Therapy: Focus on Gut Microbiota. Int J Biol Sci 2022; 18(4):1451-1475. doi:10.7150/ijbs.68170. https://www.ijbs.com/v18p1451.htm

CSE
Wang M, Yu F, Zhang Y, Chang W, Zhou M. 2022. The Effects and Mechanisms of Flavonoids on Cancer Prevention and Therapy: Focus on Gut Microbiota. Int J Biol Sci. 18(4):1451-1475.

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