Int J Biol Sci 2022; 18(5):1829-1843. doi:10.7150/ijbs.66917 This issue

Review

Ferroptosis in Cancer Progression: Role of Noncoding RNAs

Ying-Bing Zuo1,2*, Yin-Feng Zhang2*✉, Rui Zhang1, Jia-Wei Tian3, Xiao-Bing Lv1, Rong Li1, Shu-Ping Li4, Meng-Die Cheng1,2, Jing Shan2,5,6, Zheng Zhao1,2, Hui Xin1✉

1. Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266000, Shandong, P.R. China.
2. Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Deng Zhou Road 38, Qingdao 266021, Shandong, P.R. China.
3. Department of Emergency Internal Medicine, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, P.R. China.
4. Department of Cardiology, The Affiliated Qingdao Third People's Hospital of Qingdao University, Qingdao University, Qingdao 266041, Shandong, P.R. China.
5. Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan 750004, Ningxia, P.R. China.
6. School of Public Health and Management, Ningxia Medical University, Yinchuan 750004, Ningxia, P.R. China.
*These authors contributed equally.

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Citation:
Zuo YB, Zhang YF, Zhang R, Tian JW, Lv XB, Li R, Li SP, Cheng MD, Shan J, Zhao Z, Xin H. Ferroptosis in Cancer Progression: Role of Noncoding RNAs. Int J Biol Sci 2022; 18(5):1829-1843. doi:10.7150/ijbs.66917. Available from https://www.ijbs.com/v18p1829.htm

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Abstract

Graphic abstract

Ferroptosis is a novel form of programmed cell death, and it is characterized by iron-dependent oxidative damage, lipid peroxidation and reactive oxygen species accumulation. Notable studies have revealed that ferroptosis plays vital roles in tumor occurrence and that abundant ferroptosis in cells can inhibit tumor progression. Recently, some noncoding RNAs (ncRNAs), particularly microRNAs, long noncoding RNAs, and circular RNAs, have been shown to be involved in biological processes of ferroptosis, thus affecting cancer growth. However, the definite regulatory mechanism of this phenomenon is still unclear. To clarify this issue, increasing studies have focused on the regulatory roles of ncRNAs in the initiation and development of ferroptosis and the role of ferroptosis in progression of various cancers, such as lung, liver, and breast cancers. In this review, we systematically summarized the relationship between ferroptosis-associated ncRNAs and cancer progression. Moreover, additional evidence is needed to identify the role of ferroptosis-related ncRNAs in cancer progression. This review will help us to understand the roles of ncRNAs in ferroptosis and cancer progression and may provide new ideas for exploring novel diagnostic and therapeutic biomarkers for cancer in the future.

Keywords: Ferroptosis, microRNAs, long noncoding RNAs, circular RNAs, Cell death