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Volume 18 (5); 2022

Research Papers

Ferroptosis-associated molecular classification characterized by distinct tumor microenvironment profiles in colorectal cancer
Wenqin Luo, Weixing Dai, Qingguo Li, Shaobo Mo, Lingyu Han, Xiuying Xiao, Ruiqi Gu, Wenqiang Xiang, Li Ye, Renjie Wang, Ye Xu, Sanjun Cai, Guoxiang Cai
Int. J. Biol. Sci. 2022; 18(5): 1773-1794. doi:10.7150/ijbs.69808
[Abstract] [Full text] [PDF] [PubMed] [PMC]

TBC1D14 inhibits autophagy to suppress lymph node metastasis in head and neck squamous cell carcinoma by downregulating macrophage erythroblast attacher
Tao Lu, Yanshi Li, Min Pan, Dan Yu, Zhihai Wang, Chuan Liu, Guohua Hu
Int. J. Biol. Sci. 2022; 18(5): 1795-1812. doi:10.7150/ijbs.68992
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Lipidomic Trajectories Characterize Delayed Mucosal Wound Healing in Quiescent Ulcerative Colitis and Identify Potential Novel Therapeutic Targets
Jacob Tveiten Bjerrum, Yulan Wang, Jingtao Zhang, Lene Buhl Riis, Ole Haagen Nielsen, Jakob Benedict Seidelin
Int. J. Biol. Sci. 2022; 18(5): 1813-1828. doi:10.7150/ijbs.67112
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice
Zydrune Polianskyte-Prause, Tuomas A. Tolvanen, Sonja Lindfors, Kanta Kon, Laura C. Hautala, Hong Wang, Tsutomu Wada, Hiroshi Tsuneki, Toshiyasu Sasaoka, Sanna Lehtonen
Int. J. Biol. Sci. 2022; 18(5): 1852-1864. doi:10.7150/ijbs.66314
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Radiosensitizer EXO-miR-197-3p Inhibits Nasopharyngeal Carcinoma Progression and Radioresistance by Regulating the AKT/mTOR Axis and HSPA5-mediated Autophagy
Jiahui Jiang, Qiao Tang, Jiaoe Gong, WeiHong Jiang, Yiting Chen, Qi Zhou, Alaa Aldeen, Shuanglian Wang, Chengmin Li, Wuwu Lv, Tao Du, Xingwei Wang, Xueying Long, Xueping Feng
Int. J. Biol. Sci. 2022; 18(5): 1878-1895. doi:10.7150/ijbs.69934
[Abstract] [Full text] [PDF] [PubMed] [PMC]

MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathy
Meng-Ran Li, Chun-Tao Lei, Hui Tang, Xing-Jie Yin, Zhe Hao, Yang Qiu, Ya-Ru Xie, Jie-Yu Zeng, Hua Su, Chun Zhang
Int. J. Biol. Sci. 2022; 18(5): 1896-1911. doi:10.7150/ijbs.68977
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Metabolomics reveals that CAF-derived lipids promote colorectal cancer peritoneal metastasis by enhancing membrane fluidity
Shaoyong Peng, Yingjie Li, Meijin Huang, Guannan Tang, Yumo Xie, Daici Chen, Yumin Hu, Tiantian Yu, Jian Cai, Zixu Yuan, Huaiming Wang, Hui Wang, Yanxin Luo, Xiaoxia Liu
Int. J. Biol. Sci. 2022; 18(5): 1912-1932. doi:10.7150/ijbs.68484
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Interleukin-17 programs liver progenitor cell transformation into cancer stem cells through mir-122 downregulation with increased risk of primary liver cancer initiation
Imène Gasmi, Camilia Machou, Aurélie Rodrigues, Arthur Brouillet, Trung Cong Nguyen, Benoit Rousseau, Adrien Guillot, Christophe Rodriguez, Vanessa Demontant, Yeni Ait-Ahmed, Julien Calderaro, Alain Luciani, Jean-Michel Pawlotsky, Fouad Lafdil
Int. J. Biol. Sci. 2022; 18(5): 1944-1960. doi:10.7150/ijbs.70408
[Abstract] [Full text] [PDF] [PubMed] [PMC]

SCM-198 Alleviates Endometriosis by Suppressing Estrogen-ERα mediated Differentiation and Function of CD4⁺CD25⁺ Regulatory T Cells
Yun-yun Li, Yi-kong Lin, Yue Li, Xin-hua Liu, Da-jin Li, Xiao-lin Wang, Li Wang, Yi-zhun Zhu, Min Yu, Mei-rong Du
Int. J. Biol. Sci. 2022; 18(5): 1961-1973. doi:10.7150/ijbs.68224
[Abstract] [Full text] [PDF] [PubMed] [PMC]

LncRNA CASC15, MiR-23b Cluster and SMAD3 form a Novel Positive Feedback Loop to promote Epithelial-Mesenchymal Transition and Metastasis in Ovarian Cancer
Hui Lin, Xian Xu, Kelie Chen, Zhiqin Fu, Shengchao Wang, Yaqing Chen, Honghe Zhang, Yuequn Niu, Hanwen Chen, Hongfei Yu, Jian-zhong Shao, Weiguo Lu, Yihua Wu, Dajing Xia
Int. J. Biol. Sci. 2022; 18(5): 1989-2002. doi:10.7150/ijbs.67486
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Dissection of Targeting Molecular Mechanisms of Aristolochic Acid-induced Nephrotoxicity via a Combined Deconvolution Strategy of Chemoproteomics and Metabolomics
Qian Zhang, Piao Luo, Jiayun Chen, Chuanbin Yang, Fei Xia, Junzhe Zhang, Huan Tang, Dandan Liu, Liwei Gu, Qiaoli Shi, Xueling He, Tong Yang, Jigang Wang
Int. J. Biol. Sci. 2022; 18(5): 2003-2017. doi:10.7150/ijbs.69618
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Hgs Deficiency Caused Restrictive Cardiomyopathy via Disrupting Proteostasis
Zhenhua Li, Tianle Wang, Chong Xin, Yao Song, Jingyi Kong, Jingping Xu, Qiqi Liu, Yan Teng, Ning Hou, Xuan Cheng, Guan Yang, Wenjia Liu, Bin Zhou, Youyi Zhang, Xiao Yang, Jian Wang
Int. J. Biol. Sci. 2022; 18(5): 2018-2031. doi:10.7150/ijbs.69024
[Abstract] [Full text] [PDF] [PubMed] [PMC]

PROX1 promotes breast cancer invasion and metastasis through WNT/β-catenin pathway via interacting with hnRNPK
Lizhe Zhu, Qi Tian, Huan Gao, Kaijie Wu, Bo Wang, Guanqun Ge, Siyuan Jiang, Ke Wang, Can Zhou, Jianjun He, Peijun Liu, Yu Ren, Bin Wang
Int. J. Biol. Sci. 2022; 18(5): 2032-2046. doi:10.7150/ijbs.68960
[Abstract] [Full text] [PDF] [PubMed] [PMC]

HB-EGF induces mitochondrial dysfunction via estrogen hypersecretion in granulosa cells dependent on cAMP-PKA-JNK/ERK-Ca²⁺-FOXO1 pathway
Ji-Cheng Huang, Cui-Cui Duan, Shan Jin, Chuan-Bo Sheng, Yu-Si Wang, Zhan-Peng Yue, Bin Guo
Int. J. Biol. Sci. 2022; 18(5): 2047-2059. doi:10.7150/ijbs.69343
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Icariside II enhances cisplatin-induced apoptosis by promoting endoplasmic reticulum stress signalling in non-small cell lung cancer cells
Zhao Tang, Wenjing Du, Fei Xu, Xianjun Sun, Wenjing Chen, Jie Cui, Weifeng Tang, Fangyong Yang, Fangzhou Teng, Jinpei Lin, Baojun Liu, Jingcheng Dong
Int. J. Biol. Sci. 2022; 18(5): 2060-2074. doi:10.7150/ijbs.66630
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Forsythoside A Mitigates Alzheimer's-like Pathology by Inhibiting Ferroptosis-mediated Neuroinflammation via Nrf2/GPX4 Axis Activation
Chunyue Wang, Shanshan Chen, Hangyu Guo, Hongbo Jiang, Honghan Liu, Haoran Fu, Di Wang
Int. J. Biol. Sci. 2022; 18(5): 2075-2090. doi:10.7150/ijbs.69714
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Specific overexpression of SIRT1 in mesenchymal stem cells rescues hematopoiesis niche in BMI1 knockout mice through promoting CXCL12 expression
Jinbo Li, Xing Li, Wen Sun, Jiao Zhang, Quanquan Yan, Jun Wu, Jianliang Jin, Ruinan Lu, Dengshun Miao
Int. J. Biol. Sci. 2022; 18(5): 2091-2103. doi:10.7150/ijbs.63876
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Histone Deacetylase Inhibitors (HDACi) Promote KLF5 Ubiquitination and Degradation in Basal-like Breast Cancer
Yanjie Kong, Wenlong Ren, Huan Fang, Naseer Ali Shah, Yujie Shi, Dingyun You, Chengang Zhou, Dewei Jiang, Chuanyu Yang, Huichun Liang, Wenjin Liu, Luzhen Wang, Wenqiang Gan, Xing Wan, Fubing Li, Zhen Li, Ceshi Chen, Ni Xie
Int. J. Biol. Sci. 2022; 18(5): 2104-2115. doi:10.7150/ijbs.65322
[Abstract] [Full text] [PDF] [PubMed] [PMC]

CircRAPGEF5 Promotes the Proliferation and Metastasis of Lung Adenocarcinoma through the miR-1236-3p/ZEB1 Axis and Serves as a Potential Biomarker
Huixin Zhou, Xiaolu Huang, Xiang Yang, Feng Jiang, Fanggui Shao, Wenjing Shi, Kate Huang, Jingjing Pan, Yan Zhang, Jie Chen, Yumin Wang
Int. J. Biol. Sci. 2022; 18(5): 2116-2131. doi:10.7150/ijbs.66770
[Abstract] [Full text] [PDF] [PubMed] [PMC]

The RNF26/CBX7 axis modulates the TNF pathway to promote cell proliferation and regulate sensitivity to TKIs in ccRCC
Wentao Liu, Haohui Wang, Chengzhu Jian, Wei Li, Kun Ye, Jiannan Ren, Liang Zhu, Yinhuai Wang, Xin Jin, Lu Yi
Int. J. Biol. Sci. 2022; 18(5): 2132-2145. doi:10.7150/ijbs.69325
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Urolithin A protects against acetaminophen-induced liver injury in mice via sustained activation of Nrf2
Zhimin Gao, Wei Yi, Junyuan Tang, Yuling Sun, Jianrong Huang, Tian Lan, Xiaoyan Dai, Suowen Xu, Zheng-Gen Jin, Xiaoqian Wu
Int. J. Biol. Sci. 2022; 18(5): 2146-2162. doi:10.7150/ijbs.69116
[Abstract] [Full text] [PDF] [PubMed] [PMC]

TET1s deficiency exacerbates oscillatory shear flow-induced atherosclerosis
Kai Qu, Caihong Wang, Lu Huang, Xian Qin, Kun Zhang, Yuan Zhong, Qingfeng Ma, Wenhua Yan, Tianhan Li, Qin Peng, Yi Wang, Hans Gregersen, Chaojun Tang, Juhui Qiu, Guixue Wang
Int. J. Biol. Sci. 2022; 18(5): 2163-2180. doi:10.7150/ijbs.69281
[Abstract] [Full text] [PDF] [PubMed] [PMC]

SENP1 promotes triple-negative breast cancer invasion and metastasis via enhancing CSN5 transcription mediated by GATA1 deSUMOylation
Yongchang Gao, Rongrong Wang, Jianjing Liu, Ke Zhao, Xiaolong Qian, Xianghui He, Hong Liu
Int. J. Biol. Sci. 2022; 18(5): 2186-2201. doi:10.7150/ijbs.60594
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Melatonin reverses tumor necrosis factor-alpha-induced metabolic disturbance of human nucleus pulposus cells via MTNR1B/Gαi2/YAP signaling
Xianjian Qiu, Tongzhou Liang, Zizhao Wu, Yuanxin Zhu, Wenjie Gao, Bo Gao, Jincheng Qiu, Xudong Wang, Taiqiu Chen, Zhihuai Deng, Pengfei Li, Yanbo Chen, Hang Zhou, Yan Peng, Caixia Xu, Peiqiang Su, Anjing Liang, Dongsheng Huang
Int. J. Biol. Sci. 2022; 18(5): 2202-2219. doi:10.7150/ijbs.65973
[Abstract] [Full text] [PDF] [PubMed] [PMC]

miR-200c suppression increases tau hyperphosphorylation by targeting 14-3-3γ in early stage of 5xFAD mouse model of Alzheimer's disease
Hyunjun Park, Yeong-Bae Lee, Keun-A Chang
Int. J. Biol. Sci. 2022; 18(5): 2220-2234. doi:10.7150/ijbs.66604
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Reviews

Ferroptosis in Cancer Progression: Role of Noncoding RNAs
Ying-Bing Zuo, Yin-Feng Zhang, Rui Zhang, Jia-Wei Tian, Xiao-Bing Lv, Rong Li, Shu-Ping Li, Meng-Die Cheng, Jing Shan, Zheng Zhao, Hui Xin
Int. J. Biol. Sci. 2022; 18(5): 1829-1843. doi:10.7150/ijbs.66917
[Abstract] [Full text] [PDF] [PubMed] [PMC]

B.1.617.2 (Delta) Variant of SARS-CoV-2: features, transmission and potential strategies
Yan Zhan, Hui Yin, Ji-Ye Yin
Int. J. Biol. Sci. 2022; 18(5): 1844-1851. doi:10.7150/ijbs.66881
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Immune response and potential therapeutic strategies for the SARS-CoV-2 associated with the COVID-19 pandemic
Xianghui Li, Yabo Zhang, Libing He, Jiangzhe Si, Shuai Qiu, Yuhua He, Jiacun Wei, Zhili Wang, Longxiang Xie, Yanzhang Li, Tieshan Teng
Int. J. Biol. Sci. 2022; 18(5): 1865-1877. doi:10.7150/ijbs.66369
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Alterations in synaptonemal complex coding genes and human infertility
Fengguo Zhang, Mengfei Liu, Jinmin Gao
Int. J. Biol. Sci. 2022; 18(5): 1933-1943. doi:10.7150/ijbs.67843
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Regulation of CD38 on Multiple Myeloma and NK Cells by Monoclonal Antibodies
Hao-Tian Wu, Xiang-Yu Zhao
Int. J. Biol. Sci. 2022; 18(5): 1974-1988. doi:10.7150/ijbs.68148
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Errata

Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1^G93A Mice: Erratum
Qi Zhou, Lei Zhu, Weiwen Qiu, Yue Liu, Fang Yang, Wenzhi Chen, Renshi Xu
Int. J. Biol. Sci. 2022; 18(5): 2181-2183. doi:10.7150/ijbs.71902
[Abstract] [Full text] [PDF] [PubMed] [PMC]

MiR-216a-5p inhibits tumorigenesis in Pancreatic Cancer by targeting TPT1/mTORC1 and is mediated by LINC01133: Erratum
Jian Zhang, Shuohui Gao, Yandong Zhang, Huixin Yi, Mengxian Xu, Jialun Xu, Huan Liu, Zhichen Ding, Hongbin He, Hongmei Wang, Zhuo Hao, Liankun Sun, Yan Liu, Feng Wei
Int. J. Biol. Sci. 2022; 18(5): 2184-2185. doi:10.7150/ijbs.70911
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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