Int J Biol Sci 2022; 18(6):2292-2303. doi:10.7150/ijbs.69411 This issue

Review

The role of ubiquitination and deubiquitination in tumor invasion and metastasis

Shuangze Han1, Ruike Wang1, Yangnan Zhang1, Xiaoying Li1, Yu Gan1, Feng Gao3✉, Pengfei Rong1,2✉, Wei Wang1,2✉, Wei Li1,2✉

1. Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China
2. Cell Transplantation and Gene Therapy Institute, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China
3. Department of Ultrasonography, The Third Xiangya Hospital of Central South University, Changsha, Hunan, 410013, China

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Citation:
Han S, Wang R, Zhang Y, Li X, Gan Y, Gao F, Rong P, Wang W, Li W. The role of ubiquitination and deubiquitination in tumor invasion and metastasis. Int J Biol Sci 2022; 18(6):2292-2303. doi:10.7150/ijbs.69411. Available from https://www.ijbs.com/v18p2292.htm

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Abstract

Graphic abstract

Ubiquitination is vital for multiple cellular processes via dynamic modulation of proteins related to cell growth, proliferation, and survival. Of the ubiquitination system components, E3 ubiquitin ligases and deubiquitinases have the most prominent roles in modulating tumor metastasis. This review will briefly summarize the observations and underlying mechanisms of multiple E3 ubiquitin ligases and deubiquitinases to regulate tumor metastasis. Further, we will discuss the relationship and importance between ubiquitination components and tumor progression.

Keywords: ubiquitination, E3 ubiquitin ligase, deubiquitinase, metastasis