Int J Biol Sci 2022; 18(10):4260-4274. doi:10.7150/ijbs.72251 This issue

Review

Emerging Mechanisms and Targeted Therapy of Ferroptosis in Neurological Diseases and Neuro-oncology

Yajie Wang1#, Bufu Tang1,3#, Jinyu Zhu1,3, Junchao Yu1, Junguo Hui1,2,3, Shuiwei Xia1,2,3✉, Jiansong Ji1,2,3✉

1. Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, People's Republic of China.
2. School of medicine, Lishui University, Lishui, 323000, People's Republic of China.
3. Department of Radiology, School of Medicine, Lishui Hospital of Zhejiang University, Hangzhou 310016, People's Republic of China.
#These authors contribute equally to this work.

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Citation:
Wang Y, Tang B, Zhu J, Yu J, Hui J, Xia S, Ji J. Emerging Mechanisms and Targeted Therapy of Ferroptosis in Neurological Diseases and Neuro-oncology. Int J Biol Sci 2022; 18(10):4260-4274. doi:10.7150/ijbs.72251. Available from https://www.ijbs.com/v18p4260.htm

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Abstract

Graphic abstract

Ferroptosis is a novel type of cell death characterized by iron-dependent lipid peroxidation that involves a variety of biological processes, such as iron metabolism, lipid metabolism, and oxidative stress. A growing body of research suggests that ferroptosis is associated with cancer and neurodegenerative diseases, such as glioblastoma, Alzheimer's disease, Parkinson's disease, and stroke. Building on these findings, we can selectively induce ferroptosis for the treatment of certain cancers, or we can treat neurodegenerative diseases by inhibiting ferroptosis. This review summarizes the relevant advances in ferroptosis, the regulatory mechanisms of ferroptosis, the participation of ferroptosis in brain tumors and neurodegenerative diseases, and the corresponding drug therapies to provide new potential targets for its treatment.

Keywords: ferroptosis, iron metabolism, GSH, GPX4, lipid peroxidation, neurodegenerative diseases