Int J Biol Sci 2022; 18(11):4372-4387. doi:10.7150/ijbs.72397 This issue Cite

Research Paper

DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis

Xiang Zhu1,2#, Chunyuan Xue2#, Xiaofeng Kang2#, Xiaomeng Jia1#, Lin Wang1, Muhsin H. Younis3, Donghui Liu4, Nan Huo2, Yuchen Han2, Zhao Chen5, Jing Fu6, Chunyu Zhou6, Xiaoxiang Yao6, Yimeng Du2✉, Weibo Cai3✉, Lei Kang5✉, Zhaohui Lyu1✉

1. Department of Endocrinology, the First Medical Center of PLA General Hospital, Beijing, China.
2. Department of Genetic Engineering, Beijing Institute of Biotechnology, Beijing, China.
3. Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.
4. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
5. Department of Nuclear Medicine, Peking University First Hospital, Beijing, China.
6. Department of Pathology, Beijing Haidian Hospital, Beijing, China.
#These authors contributed equally to this work.

Citation:
Zhu X, Xue C, Kang X, Jia X, Wang L, Younis MH, Liu D, Huo N, Han Y, Chen Z, Fu J, Zhou C, Yao X, Du Y, Cai W, Kang L, Lyu Z. DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis. Int J Biol Sci 2022; 18(11):4372-4387. doi:10.7150/ijbs.72397. https://www.ijbs.com/v18p4372.htm
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Abstract

Graphic abstract

Over the past decades, the incidence of thyroid cancer (TC) rapidly increased all over the world, with the papillary thyroid cancer (PTC) accounting for the vast majority of TC cases. It is crucial to investigate novel diagnostic and therapeutic targets for PTC and explore more detailed molecular mechanisms in the carcinogenesis and progression of PTC. Based on the TCGA and GEO databases, FAM111B is downregulated in PTC tissues and predicts better prognosis in PTC patients. FAM111B suppresses the growth, migration, invasion and glycolysis of PTC both in vitro and in vivo. Furthermore, estrogen inhibits FAM111B expression by DNMT3B methylation via enhancing the recruitment of DNMT3B to FAM111B promoter. DNMT3B-mediated FAM111B methylation accelerates the growth, migration, invasion and glycolysis of PTC cells. In clinical TC patient specimens, the expression of FAM111B is inversely correlated with the expressions of DNMT3B and the glycolytic gene PGK1. Besides, the expression of FAM111B is inversely correlated while DNMT3B is positively correlated with glucose uptake in PTC patients. Our work established E2/DNMT3B/FAM111B as a crucial axis in regulating the growth and progression of PTC. Suppression of DNMT3B or promotion of FAM111B will be potential promising strategies in the estrogen induced PTC.

Keywords: Papillary thyroid cancer, FAM111B, DNMT3B, Glycolysis, Estrogen


Citation styles

APA
Zhu, X., Xue, C., Kang, X., Jia, X., Wang, L., Younis, M.H., Liu, D., Huo, N., Han, Y., Chen, Z., Fu, J., Zhou, C., Yao, X., Du, Y., Cai, W., Kang, L., Lyu, Z. (2022). DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis. International Journal of Biological Sciences, 18(11), 4372-4387. https://doi.org/10.7150/ijbs.72397.

ACS
Zhu, X.; Xue, C.; Kang, X.; Jia, X.; Wang, L.; Younis, M.H.; Liu, D.; Huo, N.; Han, Y.; Chen, Z.; Fu, J.; Zhou, C.; Yao, X.; Du, Y.; Cai, W.; Kang, L.; Lyu, Z. DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis. Int. J. Biol. Sci. 2022, 18 (11), 4372-4387. DOI: 10.7150/ijbs.72397.

NLM
Zhu X, Xue C, Kang X, Jia X, Wang L, Younis MH, Liu D, Huo N, Han Y, Chen Z, Fu J, Zhou C, Yao X, Du Y, Cai W, Kang L, Lyu Z. DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis. Int J Biol Sci 2022; 18(11):4372-4387. doi:10.7150/ijbs.72397. https://www.ijbs.com/v18p4372.htm

CSE
Zhu X, Xue C, Kang X, Jia X, Wang L, Younis MH, Liu D, Huo N, Han Y, Chen Z, Fu J, Zhou C, Yao X, Du Y, Cai W, Kang L, Lyu Z. 2022. DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis. Int J Biol Sci. 18(11):4372-4387.

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