Int J Biol Sci 2022; 18(13):5185-5206. doi:10.7150/ijbs.72600 This issue

Review

The role of intestinal stem cell within gut homeostasis: Focusing on its interplay with gut microbiota and the regulating pathways

Haoming Luo1,2,#, Mingxing Li1,2,#, Fang Wang1,2,#, Yifei Yang1,2, Qin Wang1,2, Yueshui Zhao1,2,3, Fukuan Du1,2,3, Yu Chen1,2,3, Jing Shen1,2,3, Qianyun Zhao1,2, Jiuping Zeng1,2, Shengpeng Wang4, Meijuan Chen1, Xiaobing Li1, Wanping Li1, Yuhong Sun1, Li Gu1, Qinglian Wen5, Zhangang Xiao5,1✉, Xu Wu1,4✉

1. Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, Sichuan, China.
2. Cell Therapy & Cell Drugs of Luzhou Key Laboratory, Luzhou 646000, Sichuan, China.
3. South Sichuan Institute of Translational Medicine, Luzhou 646000, Sichuan, China.
4. State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao, China.
5. Department of Oncology, Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China.
# These authors contributed equally to the work.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Citation:
Luo H, Li M, Wang F, Yang Y, Wang Q, Zhao Y, Du F, Chen Y, Shen J, Zhao Q, Zeng J, Wang S, Chen M, Li X, Li W, Sun Y, Gu L, Wen Q, Xiao Z, Wu X. The role of intestinal stem cell within gut homeostasis: Focusing on its interplay with gut microbiota and the regulating pathways. Int J Biol Sci 2022; 18(13):5185-5206. doi:10.7150/ijbs.72600. Available from https://www.ijbs.com/v18p5185.htm

File import instruction

Abstract

Graphic abstract

Intestinal stem cells (ISCs) play an important role in maintaining intestinal homeostasis via promoting a healthy gut barrier. Within the stem cell niche, gut microbiota linking the crosstalk of dietary influence and host response has been identified as a key regulator of ISCs. Emerging insights from recent research reveal that ISC and gut microbiota interplay regulates epithelial self-renewal. This article reviews the recent knowledge on the key role of ISC in their local environment (stem cell niche) associating with gut microbiota and their metabolites as well as the signaling pathways. The current progress of intestinal organoid culture is further summarized. Subsequently, the key challenges and future directions are discussed.

Keywords: Intestinal stem cell, Intestinal barrier, Gut microbiota, Intestinal homeostasis, Signaling pathway