Int J Biol Sci 2023; 19(3):1007-1008. doi:10.7150/ijbs.82530 This issue Cite

Editorial

G against Glioma: G protein inhibitory α subunit 2 (Gαi2) as a novel glioma target

Georgios S. Markopoulos1,2✉

1. Haematology Laboratory-Unit of Molecular Biology, University Hospital of Ioannina, Ioannina, Greece.
2. Neurosurgical Institute, Faculty of Medicine, University of Ioannina, 45110 Ioannina, Greece.

Citation:
Markopoulos GS. G against Glioma: G protein inhibitory α subunit 2 (Gαi2) as a novel glioma target. Int J Biol Sci 2023; 19(3):1007-1008. doi:10.7150/ijbs.82530. https://www.ijbs.com/v19p1007.htm
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Abstract

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Glioma is among the cancers with the highest mortality and morbidity. The complex biology and acquired chemoresistance create a continuous need for novel, effective therapies. In a recent report by Wang et al, an elegant bioinformatic analysis revealed potential functions and underlying chemopreventive mechanisms involving G protein inhibitory α subunit 2 (Gαi2), which activates NF-κB, a master transcription factor in the regulation of glioma. Given that NF-κB takes part in positive regulatory feedback loops during glioma development, Gαi2 is an attractive candidate for targeted therapies. This discovery unlocks new avenues towards understanding the biology of gliomagenesis as well as the discovery of novel targeted antiglioma agents.


Citation styles

APA
Markopoulos, G.S. (2023). G against Glioma: G protein inhibitory α subunit 2 (Gαi2) as a novel glioma target. International Journal of Biological Sciences, 19(3), 1007-1008. https://doi.org/10.7150/ijbs.82530.

ACS
Markopoulos, G.S. G against Glioma: G protein inhibitory α subunit 2 (Gαi2) as a novel glioma target. Int. J. Biol. Sci. 2023, 19 (3), 1007-1008. DOI: 10.7150/ijbs.82530.

NLM
Markopoulos GS. G against Glioma: G protein inhibitory α subunit 2 (Gαi2) as a novel glioma target. Int J Biol Sci 2023; 19(3):1007-1008. doi:10.7150/ijbs.82530. https://www.ijbs.com/v19p1007.htm

CSE
Markopoulos GS. 2023. G against Glioma: G protein inhibitory α subunit 2 (Gαi2) as a novel glioma target. Int J Biol Sci. 19(3):1007-1008.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
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