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Int J Biol Sci 2023; 19(16):5218-5232. doi:10.7150/ijbs.85656 This issue Cite

Research Paper

CENPA functions as a transcriptional regulator to promote hepatocellular carcinoma progression via cooperating with YY1

Jingyu Liao1,2,3,*, Zeyu Chen1,2,3,*, Ruizhi Chang1,2,3,*, Tong Yuan1,2,3, Ganxun Li1,2,3, Chang Zhu1,2,3, Jingyuan Wen1,2,3, Yi Wei1,2,3, Zhao Huang1,2,3, Zeyang Ding1,2,3, Liang Chu1,2,3,✉, Junnan Liang1,2,3,✉, Bixiang Zhang1,2,3,✉

1. Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
2. Clinical Medical Research Center of Hepatic Surgery at Hubei Province, Wuhan, China.
3. Hubei Key Laboratory of Hepato-Pancreatic-Biliary Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
*These authors contributed equally: Jingyu Liao, Zeyu Chen, Ruizhi Chang.

✉ Corresponding authors: liangchutjmu.edu.cn; liangjunnantjmu.edu.cn; bixiangzhangedu.cn.

Citation:
Liao J, Chen Z, Chang R, Yuan T, Li G, Zhu C, Wen J, Wei Y, Huang Z, Ding Z, Chu L, Liang J, Zhang B. CENPA functions as a transcriptional regulator to promote hepatocellular carcinoma progression via cooperating with YY1. Int J Biol Sci 2023; 19(16):5218-5232. doi:10.7150/ijbs.85656. https://www.ijbs.com/v19p5218.htm
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Abstract

Graphic abstract

The centromere proteins (CENPs), a critical mitosis-related protein complexes, are involved in the kinetochore assembly and chromosome segregation. In this study, we identified that CENPA was significantly up-regulated in HCC and highly expressed CENPA correlated with poor prognosis for HCC patients. Knockdown of CENPA inhibited HCC cell proliferation and tumor growth in vitro and in vivo. Mechanistically, CENPA transcriptionally activated and cooperated with YY1 to drive the expression of cyclin D1 (CCND1) and neuropilin 2 (NRP2). Moreover, we identified that CENPA can be lactylated at lysine 124 (K124). The lactylation of CENPA at K124 promotes CENPA activation, leading to enhanced expression of its target genes. In summary, CENPA function as a transcriptional regulator to promote HCC via cooperating with YY1. Targeting the CENPA-YY1-CCND1/NRP2 axis may provide candidate therapeutic targets for HCC.

Keywords: CENPA, YY1, Lactylation, HCC

Citation styles

APA
Liao, J., Chen, Z., Chang, R., Yuan, T., Li, G., Zhu, C., Wen, J., Wei, Y., Huang, Z., Ding, Z., Chu, L., Liang, J., Zhang, B. (2023). CENPA functions as a transcriptional regulator to promote hepatocellular carcinoma progression via cooperating with YY1. International Journal of Biological Sciences, 19(16), 5218-5232. https://doi.org/10.7150/ijbs.85656.

ACS
Liao, J.; Chen, Z.; Chang, R.; Yuan, T.; Li, G.; Zhu, C.; Wen, J.; Wei, Y.; Huang, Z.; Ding, Z.; Chu, L.; Liang, J.; Zhang, B. CENPA functions as a transcriptional regulator to promote hepatocellular carcinoma progression via cooperating with YY1. Int. J. Biol. Sci. 2023, 19 (16), 5218-5232. DOI: 10.7150/ijbs.85656.

NLM
Liao J, Chen Z, Chang R, Yuan T, Li G, Zhu C, Wen J, Wei Y, Huang Z, Ding Z, Chu L, Liang J, Zhang B. CENPA functions as a transcriptional regulator to promote hepatocellular carcinoma progression via cooperating with YY1. Int J Biol Sci 2023; 19(16):5218-5232. doi:10.7150/ijbs.85656. https://www.ijbs.com/v19p5218.htm

CSE
Liao J, Chen Z, Chang R, Yuan T, Li G, Zhu C, Wen J, Wei Y, Huang Z, Ding Z, Chu L, Liang J, Zhang B. 2023. CENPA functions as a transcriptional regulator to promote hepatocellular carcinoma progression via cooperating with YY1. Int J Biol Sci. 19(16):5218-5232.

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